Defensin BmKDfsin3

UniProtKB accession:  A0A384E0Y8

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Antibacterial peptide active against Gram-positive bacteria (including S.aureus ATCC25923 (MIC=2.5 uM), M.luteus AB93113 (MIC=2.5 uM), and the antibiotic-resistant S.epidermidis PRSE P1389 (MIC=1.25 uM)), but not against Gram-negative bacteria (including E.coli and P.aeruginosa) (PubMed:31954123). Also blocks the currents of Kv1.1/KCNA1 (57% inhibition), Kv1.2/KCNA2 (27.5% inhibition), Kv1.3/KCNA3 (IC(50)=23.4 nM, 84.3% inhibition), KCa3.1/KCNN4/IK (15% inhibition), KCa2.3/KCNN3/SK3 (87.5% inhibition) and Kv11.1/KCNH2/ERG1 (30.4% inhibition) channels (tested at 1 uM) (PubMed:31954123). It inhibits potassium channel current by interacting with the pore region (PubMed:31954123).