8WCQ

Cryo-EM structure of nanodisc (PE:PS:PC) reconstituted GLIC at pH 4 in intermediate state

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: mpstruc

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B [auth E], C [auth B], D [auth C], E [auth D]	Proton-gated ion channel	ligand-gated channel activity ligand-gated monoatomic ion channel activity extracellular ligand-gated monoatomic ion channel activity passive transmembrane transporter activity gated channel activity monoatomic ion channel activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity monoatomic cation transmembrane transporter activity potassium ion transmembrane transporter activity potassium channel activity monoatomic cation channel activity ligand-gated channel activity ligand-gated monoatomic ion channel activity extracellular ligand-gated monoatomic ion channel activity passive transmembrane transporter activity gated channel activity monoatomic ion channel activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity monoatomic cation transmembrane transporter activity potassium ion transmembrane transporter activity potassium channel activity monoatomic cation channel activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity metal ion transmembrane transporter activity sodium channel activity sodium ion transmembrane transporter activity identical protein binding protein binding binding molecular transducer activity transmembrane signaling receptor activity signaling receptor activity	-	cell periphery plasma membrane membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B [auth E], C [auth B], D [auth C], E [auth D]	IPR038050	Neuronal acetylcholine receptor	Homologous Superfamily
A, B [auth E], C [auth B], D [auth C], E [auth D]	IPR006202	Neurotransmitter-gated ion-channel ligand-binding domain	Domain
A, B [auth E], C [auth B], D [auth C], E [auth D]	IPR036719	Neurotransmitter-gated ion-channel transmembrane domain superfamily	Homologous Superfamily
A, B [auth E], C [auth B], D [auth C], E [auth D]	IPR006028	Gamma-aminobutyric acid A receptor/Glycine receptor alpha	Family
A, B [auth E], C [auth B], D [auth C], E [auth D]	IPR036734	Neurotransmitter-gated ion-channel ligand-binding domain superfamily	Homologous Superfamily
A, B [auth E], C [auth B], D [auth C], E [auth D]	IPR006201	Neurotransmitter-gated ion-channel	Family

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B [auth E], C [auth B], D [auth C], E [auth D]	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B [auth E], C [auth B], D [auth C], E [auth D]	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Cys-Loop Receptor Family	Prokaryotic pentameric ligand-gated ion channel (GLIC) reconstituted in asolectin nanodisc, pH 7.5

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.