8W9A

CryoEM structure of human PI3K-alpha (P85/P110-H1047R) with QR-7909 binding at an allosteric site

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	kinase activity transferase activity catalytic activity transferase activity, transferring phosphorus-containing groups protein binding binding insulin receptor substrate binding phosphatidylinositol kinase activity lipid kinase activity 1-phosphatidylinositol-3-kinase activity phosphotransferase activity, alcohol group as acceptor 1-phosphatidylinositol-4-phosphate 3-kinase activity adenyl ribonucleotide binding nucleotide binding kinase activity transferase activity catalytic activity transferase activity, transferring phosphorus-containing groups protein binding binding insulin receptor substrate binding phosphatidylinositol kinase activity lipid kinase activity 1-phosphatidylinositol-3-kinase activity phosphotransferase activity, alcohol group as acceptor 1-phosphatidylinositol-4-phosphate 3-kinase activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity enzyme regulator activity kinase activator activity enzyme activator activity molecular function activator activity molecular function regulator activity protein kinase activator activity protein kinase regulator activity kinase regulator activity catalytic activity, acting on a protein protein kinase activity protein serine kinase activity protein serine/threonine kinase activity	cellular biosynthetic process glycerophospholipid metabolic process lipid biosynthetic process phospholipid metabolic process organic substance metabolic process organic substance biosynthetic process phosphate-containing compound metabolic process phosphorus metabolic process phosphatidylinositol metabolic process glycerophospholipid biosynthetic process phosphatidylinositol-3-phosphate biosynthetic process cellular metabolic process primary metabolic process phosphatidylinositol phosphate biosynthetic process cellular biosynthetic process glycerophospholipid metabolic process lipid biosynthetic process phospholipid metabolic process organic substance metabolic process organic substance biosynthetic process phosphate-containing compound metabolic process phosphorus metabolic process phosphatidylinositol metabolic process glycerophospholipid biosynthetic process phosphatidylinositol-3-phosphate biosynthetic process cellular metabolic process primary metabolic process phosphatidylinositol phosphate biosynthetic process phospholipid biosynthetic process phosphatidylinositol biosynthetic process biosynthetic process glycerolipid biosynthetic process organophosphate metabolic process organophosphate biosynthetic process cellular lipid metabolic process metabolic process cellular process glycerolipid metabolic process lipid metabolic process localization import into cell transport phagocytosis endocytosis establishment of localization vesicle-mediated transport cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction positive regulation of TOR signaling signal transduction positive regulation of cellular process TOR signaling regulation of biological process regulation of signaling regulation of TOR signaling biological regulation positive regulation of intracellular signal transduction regulation of response to stimulus regulation of cell communication positive regulation of signaling epithelium migration multicellular organismal process tissue migration endothelial cell migration ameboidal-type cell migration epithelial cell migration cell migration cell motility cellular response to growth factor stimulus cell surface receptor signaling pathway response to endogenous stimulus cell surface receptor protein tyrosine kinase signaling pathway vascular endothelial growth factor signaling pathway cellular response to endogenous stimulus cellular response to vascular endothelial growth factor stimulus response to growth factor enzyme-linked receptor protein signaling pathway response to acid chemical response to organic substance response to chemical response to organonitrogen compound response to oxygen-containing compound response to nitrogen compound response to amino acid response to L-leucine negative regulation of programmed cell death regulation of apoptotic process regulation of anoikis negative regulation of biological process regulation of programmed cell death cell death negative regulation of anoikis negative regulation of apoptotic process anoikis negative regulation of cellular process apoptotic process programmed cell death regulation of cytoskeleton organization regulation of actin filament organization regulation of cellular component organization regulation of actin filament-based process actin cytoskeleton organization actin filament organization regulation of organelle organization cellular component organization organelle organization regulation of actin cytoskeleton organization actin filament-based process regulation of supramolecular fiber organization cellular component organization or biogenesis supramolecular fiber organization cytoskeleton organization insulin-like growth factor receptor signaling pathway response to muscle inactivity response to inactivity fibroblast apoptotic process negative regulation of fibroblast apoptotic process regulation of fibroblast apoptotic process protein localization regulation of localization cellular localization regulation of protein localization positive regulation of protein localization to membrane localization within membrane protein localization to membrane regulation of cellular localization cellular macromolecule localization macromolecule localization positive regulation of protein localization regulation of protein localization to membrane regulation of multicellular organism growth developmental process regulation of growth regulation of developmental growth regulation of developmental process developmental growth growth multicellular organism growth regulation of multicellular organismal process monosaccharide metabolic process carbohydrate metabolic process hexose metabolic process small molecule metabolic process glucose metabolic process regulation of body fluid levels wound healing cell activation hemostasis blood coagulation response to stress coagulation regulation of biological quality response to wounding platelet activation ERBB signaling pathway epidermal growth factor receptor signaling pathway response to ketone response to lipid response to glucocorticoid response to corticosteroid response to hormone response to steroid hormone response to dexamethasone response to organic cyclic compound cell population proliferation regulation of smooth muscle cell proliferation positive regulation of cell population proliferation smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation regulation of cell population proliferation muscle cell proliferation phosphorylation regulation of leukocyte activation regulation of cell activation positive regulation of leukocyte cell-cell adhesion lymphocyte activation leukocyte cell-cell adhesion leukocyte activation positive regulation of cell-cell adhesion positive regulation of lymphocyte activation positive regulation of cell activation cell adhesion cell-cell adhesion T cell activation positive regulation of leukocyte activation regulation of immune system process regulation of cell-cell adhesion positive regulation of immune system process positive regulation of T cell activation positive regulation of cell adhesion regulation of cell adhesion regulation of T cell activation immune system process lymphocyte costimulation regulation of leukocyte cell-cell adhesion positive regulation of multicellular organismal process T cell costimulation regulation of lymphocyte activation multicellular organism development anatomical structure development vasculature development system development circulatory system development hepaticobiliary system development gland development animal organ development liver development system process relaxation of cardiac muscle muscle system process relaxation of muscle connective tissue development adipose tissue development tissue development immune response-regulating cell surface receptor signaling pathway immune response-activating signaling pathway immune response-regulating signaling pathway positive regulation of immune response immune response-activating cell surface receptor signaling pathway immune response T cell receptor signaling pathway regulation of immune response antigen receptor-mediated signaling pathway activation of immune response blood vessel morphogenesis tube development angiogenesis anatomical structure morphogenesis tube morphogenesis anatomical structure formation involved in morphogenesis blood vessel development intracellular signaling cassette phosphatidylinositol 3-kinase/protein kinase B signal transduction homeostatic process response to monosaccharide response to carbohydrate carbohydrate homeostasis cellular response to hexose stimulus intracellular chemical homeostasis cellular response to monosaccharide stimulus cellular response to organic substance cellular response to glucose stimulus intracellular glucose homeostasis cellular response to oxygen-containing compound response to hexose cellular response to carbohydrate stimulus cellular response to chemical stimulus cellular homeostasis chemical homeostasis response to glucose glucose homeostasis response to activity response to butyrate response to fatty acid multicellular organismal-level homeostasis energy homeostasis negative regulation of cellular catabolic process catabolic process macroautophagy autophagy regulation of autophagy negative regulation of cellular metabolic process cellular catabolic process process utilizing autophagic mechanism negative regulation of catabolic process negative regulation of metabolic process regulation of cellular metabolic process regulation of catabolic process negative regulation of macroautophagy regulation of macroautophagy negative regulation of autophagy regulation of cellular catabolic process regulation of metabolic process regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction neuron apoptotic process negative regulation of neuron apoptotic process regulation of neuron apoptotic process cellular response to acid chemical response to water cellular response to chemical stress response to inorganic substance cellular response to environmental stimulus cellular response to hydrostatic pressure cellular response to stress cellular response to water stimulus response to hydrostatic pressure response to abiotic stimulus cellular response to abiotic stimulus sexual reproduction cellular developmental process reproductive process cell development cellular process involved in reproduction in multicellular organism developmental process involved in reproduction gamete generation protein-DNA complex organization cell differentiation chromatin organization chromatin remodeling regulation of biosynthetic process epigenetic programming of gene expression protein-containing complex organization epigenetic regulation of gene expression multicellular organismal reproductive process regulation of macromolecule metabolic process gene expression genomic imprinting macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression autosome genomic imprinting germ cell development regulation of macromolecule biosynthetic process macromolecule metabolic process cellular response to nitrogen compound response to peptide hormone insulin receptor signaling pathway cellular response to hormone stimulus cellular response to peptide hormone stimulus cellular response to organonitrogen compound response to insulin cellular response to insulin stimulus heart process circulatory system process cardiac muscle contraction heart contraction muscle contraction blood circulation striated muscle contraction regulation of protein modification process regulation of protein phosphorylation regulation of primary metabolic process regulation of phosphate metabolic process protein metabolic process protein modification process organonitrogen compound metabolic process protein phosphorylation regulation of protein metabolic process macromolecule modification regulation of phosphorylation regulation of phosphorus metabolic process cardiac muscle cell contraction actin filament-based movement actin-mediated cell contraction regulation of cellular component size protein-containing complex disassembly regulation of protein-containing complex disassembly actin filament depolymerization regulation of actin filament depolymerization negative regulation of protein-containing complex disassembly negative regulation of supramolecular fiber organization cellular component disassembly actin polymerization or depolymerization negative regulation of cellular component organization regulation of protein depolymerization negative regulation of cytoskeleton organization regulation of actin polymerization or depolymerization negative regulation of protein depolymerization negative regulation of organelle organization regulation of actin filament length negative regulation of actin filament depolymerization protein depolymerization regulation of anatomical structure size negative regulation of macromolecule metabolic process negative regulation of cellular biosynthetic process negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process cellular respiration energy derivation by oxidation of organic compounds regulation of generation of precursor metabolites and energy generation of precursor metabolites and energy regulation of cellular respiration positive regulation of cellular component organization cell projection organization plasma membrane bounded cell projection assembly cellular component biogenesis cellular component assembly regulation of lamellipodium assembly regulation of lamellipodium organization positive regulation of cell projection organization lamellipodium assembly plasma membrane bounded cell projection organization positive regulation of cellular component biogenesis regulation of cell projection organization regulation of cell projection assembly positive regulation of lamellipodium assembly regulation of cellular component biogenesis positive regulation of lamellipodium organization regulation of plasma membrane bounded cell projection assembly lamellipodium organization cell projection assembly regulation of plasma membrane bounded cell projection organization positive regulation of plasma membrane bounded cell projection assembly response to mechanical stimulus response to external stimulus response to muscle stretch	cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium intracellular anatomical structure cytoplasm cytosol perinuclear region of cytoplasm protein-containing complex catalytic complex membrane phosphatidylinositol 3-kinase complex, class I membrane protein complex cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium intracellular anatomical structure cytoplasm cytosol perinuclear region of cytoplasm protein-containing complex catalytic complex membrane phosphatidylinositol 3-kinase complex, class I membrane protein complex transferase complex phosphatidylinositol 3-kinase complex, class IA phosphatidylinositol 3-kinase complex transferase complex, transferring phosphorus-containing groups extrinsic component of membrane cell-cell junction intercalated disc anchoring junction cell junction cell-cell contact zone cell periphery plasma membrane phosphatidylinositol 3-kinase complex, class IB
B	Phosphatidylinositol 3-kinase regulatory subunit alpha	protein binding binding insulin receptor substrate binding amide binding peptide hormone binding hormone binding insulin binding signaling receptor binding insulin receptor binding phosphatidylinositol 3-kinase binding enzyme regulator activity kinase activator activity enzyme activator activity molecular function activator activity protein binding binding insulin receptor substrate binding amide binding peptide hormone binding hormone binding insulin binding signaling receptor binding insulin receptor binding phosphatidylinositol 3-kinase binding enzyme regulator activity kinase activator activity enzyme activator activity molecular function activator activity molecular function regulator activity kinase regulator activity phosphoprotein binding phosphotyrosine residue binding protein phosphorylated amino acid binding protein phosphatase binding phosphatase binding enzyme binding neurotrophin TRK receptor binding neurotrophin TRKA receptor binding cytokine receptor binding neurotrophin receptor binding phosphatidylinositol 3-kinase regulator activity phosphatidylinositol 3-kinase activator activity insulin-like growth factor receptor binding transmembrane receptor protein tyrosine kinase adaptor activity protein tyrosine kinase binding receptor tyrosine kinase binding protein kinase binding molecular adaptor activity signaling adaptor activity signaling receptor complex adaptor activity kinase binding protein-macromolecule adaptor activity 1-phosphatidylinositol-3-kinase regulator activity protein heterodimerization activity protein dimerization activity phosphatidylinositol kinase activity kinase activity lipid kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups phosphatidylinositol 3-kinase regulatory subunit binding enzyme-substrate adaptor activity ErbB-3 class receptor binding	cellular response to stimulus response to organic substance regulation of biological process regulation of cellular process response to stimulus cell surface receptor signaling pathway signaling biological regulation response to cytokine cytokine-mediated signaling pathway cell communication cellular response to chemical stimulus response to chemical cellular response to cytokine stimulus cellular response to stimulus response to organic substance regulation of biological process regulation of cellular process response to stimulus cell surface receptor signaling pathway signaling biological regulation response to cytokine cytokine-mediated signaling pathway cell communication cellular response to chemical stimulus response to chemical cellular response to cytokine stimulus cellular process cellular response to organic substance signal transduction cellular homeostasis chemical homeostasis homeostatic process glucose homeostasis carbohydrate homeostasis intracellular chemical homeostasis intracellular glucose homeostasis regulation of protein stability regulation of biological quality protein stabilization positive regulation of protein localization to plasma membrane protein localization regulation of localization cellular localization regulation of protein localization positive regulation of biological process localization cellular macromolecule localization regulation of protein localization to membrane positive regulation of cellular process positive regulation of protein localization to cell periphery protein localization to cell periphery protein localization to plasma membrane positive regulation of protein localization to membrane localization within membrane regulation of protein localization to cell periphery protein localization to membrane regulation of cellular localization macromolecule localization positive regulation of protein localization regulation of protein localization to plasma membrane cell adhesion substrate adhesion-dependent cell spreading cell-substrate adhesion establishment of protein localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport organic substance transport intracellular transport protein localization to nucleus establishment of localization import into nucleus establishment of protein localization to organelle protein transport protein localization to organelle establishment of localization in cell protein import into nucleus intracellular protein transport myeloid leukocyte differentiation regulation of leukocyte differentiation multicellular organismal process cellular developmental process regulation of developmental process negative regulation of biological process cell development regulation of cell differentiation regulation of cell development regulation of osteoclast differentiation multicellular organism development cell differentiation osteoclast differentiation anatomical structure development negative regulation of cellular process regulation of immune system process regulation of multicellular organismal process negative regulation of cell differentiation negative regulation of hemopoiesis developmental process regulation of multicellular organismal development negative regulation of leukocyte differentiation hemopoiesis regulation of myeloid cell differentiation negative regulation of developmental process regulation of myeloid leukocyte differentiation negative regulation of myeloid cell differentiation negative regulation of osteoclast differentiation negative regulation of myeloid leukocyte differentiation negative regulation of cell development myeloid cell differentiation negative regulation of immune system process immune system process regulation of hemopoiesis negative regulation of multicellular organismal process leukocyte differentiation insulin-like growth factor receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway enzyme-linked receptor protein signaling pathway cell activation mononuclear cell differentiation lymphocyte activation lymphocyte differentiation leukocyte activation T cell activation T cell differentiation positive regulation of establishment of protein localization regulation of intracellular transport positive regulation of protein localization to nucleus positive regulation of protein import into nucleus regulation of nucleocytoplasmic transport regulation of intracellular protein transport positive regulation of intracellular protein transport positive regulation of nucleocytoplasmic transport regulation of protein localization to nucleus positive regulation of protein transport regulation of protein import into nucleus positive regulation of intracellular transport regulation of transport regulation of establishment of protein localization regulation of protein transport positive regulation of transport extrinsic apoptotic signaling pathway via death domain receptors cell death extrinsic apoptotic signaling pathway apoptotic signaling pathway apoptotic process programmed cell death cellular response to nitrogen compound response to peptide hormone cellular response to growth hormone stimulus cellular response to endogenous stimulus response to hormone cellular response to hormone stimulus growth hormone receptor signaling pathway response to endogenous stimulus response to organonitrogen compound cellular response to peptide hormone stimulus response to oxygen-containing compound response to nitrogen compound cellular response to oxygen-containing compound response to growth hormone cellular response to organonitrogen compound cell population proliferation regulation of smooth muscle cell proliferation positive regulation of cell population proliferation smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation regulation of cell population proliferation muscle cell proliferation cellular component disassembly regulation of focal adhesion disassembly regulation of cellular component organization positive regulation of cellular component organization focal adhesion disassembly cell junction disassembly cell-substrate junction disassembly positive regulation of cell-substrate junction organization cellular component organization cell junction organization positive regulation of focal adhesion disassembly cell-substrate junction organization regulation of cell-substrate junction organization cellular component organization or biogenesis positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process cellular metabolic process primary metabolic process regulation of cellular metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process positive regulation of DNA-templated transcription cellular biosynthetic process RNA metabolic process positive regulation of cellular metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process positive regulation of biosynthetic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process cellular response to stress response to stress response to endoplasmic reticulum stress B cell activation B cell differentiation immune response intracellular signal transduction intracellular signaling cassette phosphatidylinositol 3-kinase/protein kinase B signal transduction negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death negative regulation of apoptotic process regulation of cytoskeleton organization regulation of actin filament-based process regulation of actin filament bundle assembly cellular component biogenesis cellular component assembly actin filament bundle organization actin filament-based process stress fiber assembly negative regulation of supramolecular fiber organization regulation of actin filament organization negative regulation of stress fiber assembly actin cytoskeleton organization actomyosin structure organization negative regulation of cellular component organization negative regulation of cytoskeleton organization actin filament organization regulation of cellular component biogenesis negative regulation of actin filament bundle assembly regulation of organelle organization regulation of stress fiber assembly organelle organization negative regulation of organelle organization contractile actin filament bundle assembly regulation of actomyosin structure organization actin filament bundle assembly regulation of actin cytoskeleton organization regulation of supramolecular fiber organization supramolecular fiber organization cytoskeleton organization glycerophospholipid metabolic process lipid biosynthetic process phospholipid metabolic process phosphate-containing compound metabolic process phosphorus metabolic process phosphatidylinositol metabolic process glycerophospholipid biosynthetic process phosphatidylinositol phosphate biosynthetic process phospholipid biosynthetic process phosphatidylinositol biosynthetic process glycerolipid biosynthetic process organophosphate metabolic process organophosphate biosynthetic process cellular lipid metabolic process glycerolipid metabolic process lipid metabolic process RNA processing RNA splicing regulation of RNA splicing positive regulation of gene expression positive regulation of RNA splicing positive regulation of locomotion regulation of cell motility regulation of leukocyte migration positive regulation of leukocyte migration positive regulation of cell migration leukocyte migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration cell motility positive regulation of immune system process locomotion DNA damage response intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway insulin receptor signaling pathway response to insulin cellular response to insulin stimulus response to light stimulus cellular response to radiation response to UV cellular response to environmental stimulus cellular response to light stimulus response to radiation response to abiotic stimulus cellular response to abiotic stimulus cellular response to UV regulation of cell-substrate adhesion regulation of cell adhesion negative regulation of cell-matrix adhesion negative regulation of cell adhesion cell-matrix adhesion regulation of cell-matrix adhesion negative regulation of cell-substrate adhesion myeloid leukocyte migration filopodium assembly cell projection organization regulation of filopodium assembly plasma membrane bounded cell projection assembly positive regulation of cell projection organization positive regulation of filopodium assembly plasma membrane bounded cell projection organization positive regulation of cellular component biogenesis regulation of cell projection organization regulation of cell projection assembly regulation of plasma membrane bounded cell projection assembly cell projection assembly regulation of plasma membrane bounded cell projection organization positive regulation of plasma membrane bounded cell projection assembly positive regulation of response to biotic stimulus immune response-regulating cell surface receptor signaling pathway pattern recognition receptor signaling pathway regulation of signal transduction response to biotic stimulus immune response-activating signaling pathway positive regulation of immune response cell surface toll-like receptor signaling pathway innate immune response-activating signaling pathway response to other organism immune response-activating cell surface receptor signaling pathway regulation of innate immune response response to external stimulus regulation of toll-like receptor 4 signaling pathway regulation of response to stimulus defense response to other organism regulation of pattern recognition receptor signaling pathway positive regulation of defense response activation of innate immune response regulation of immune response activation of immune response regulation of defense response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of response to external stimulus innate immune response activating cell surface receptor signaling pathway positive regulation of response to stimulus positive regulation of response to external stimulus immune response-regulating signaling pathway regulation of response to stress innate immune response response to external biotic stimulus cell surface pattern recognition receptor signaling pathway regulation of signaling positive regulation of innate immune response defense response defense response to symbiont toll-like receptor 4 signaling pathway regulation of cell communication regulation of tumor necrosis factor production positive regulation of tumor necrosis factor superfamily cytokine production cytokine production regulation of cytokine production tumor necrosis factor superfamily cytokine production positive regulation of tumor necrosis factor production tumor necrosis factor production regulation of tumor necrosis factor superfamily cytokine production positive regulation of multicellular organismal process positive regulation of cytokine production cellular response to interleukin-18 response to interleukin-18 interleukin-18-mediated signaling pathway hexose transmembrane transport glucose import carbohydrate transport positive regulation of transmembrane transport glucose transmembrane transport regulation of glucose import positive regulation of glucose transmembrane transport transmembrane transport regulation of glucose transmembrane transport regulation of transmembrane transport monosaccharide transmembrane transport positive regulation of glucose import carbohydrate transmembrane transport regulation of lamellipodium assembly regulation of lamellipodium organization lamellipodium assembly positive regulation of lamellipodium assembly positive regulation of lamellipodium organization lamellipodium organization positive regulation of cell communication positive regulation of signal transduction regulation of cellular response to stress endoplasmic reticulum unfolded protein response regulation of response to endoplasmic reticulum stress regulation of endoplasmic reticulum unfolded protein response positive regulation of response to endoplasmic reticulum stress positive regulation of endoplasmic reticulum unfolded protein response cellular response to topologically incorrect protein cellular response to unfolded protein response to unfolded protein response to topologically incorrect protein positive regulation of signaling	membrane cellular anatomical entity cell-cell junction anchoring junction cell junction intracellular anatomical structure cytoplasm cytosol perinuclear region of cytoplasm protein-containing complex catalytic complex phosphatidylinositol 3-kinase complex, class I membrane protein complex transferase complex membrane cellular anatomical entity cell-cell junction anchoring junction cell junction intracellular anatomical structure cytoplasm cytosol perinuclear region of cytoplasm protein-containing complex catalytic complex phosphatidylinositol 3-kinase complex, class I membrane protein complex transferase complex phosphatidylinositol 3-kinase complex, class IA phosphatidylinositol 3-kinase complex transferase complex, transferring phosphorus-containing groups extrinsic component of membrane membrane-bounded organelle intracellular organelle Golgi apparatus cis-Golgi network organelle intracellular membrane-bounded organelle endomembrane system perinuclear endoplasmic reticulum membrane organelle subcompartment endoplasmic reticulum subcompartment perinuclear endoplasmic reticulum nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum organelle membrane endoplasmic reticulum membrane cell periphery plasma membrane nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR015433	Phosphatidylinositol kinase	Family
A	IPR016024	Armadillo-type fold	Homologous Superfamily
A	IPR037704	PI3Kalpha, catalytic domain	Domain
A	IPR002420	C2 phosphatidylinositol 3-kinase-type domain	Domain
A	IPR018936	Phosphatidylinositol 3/4-kinase, conserved site	Conserved Site
A	IPR000403	Phosphatidylinositol 3-/4-kinase, catalytic domain	Domain
A	IPR001263	Phosphoinositide 3-kinase, accessory (PIK) domain	Domain
A	IPR042236	Phosphoinositide 3-kinase, accessory (PIK) domain superfamily	Homologous Superfamily
A	IPR036940	Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily	Homologous Superfamily
A	IPR003113	Phosphatidylinositol 3-kinase, adaptor-binding domain	Domain
A	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A	IPR000341	Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain	Domain
A	IPR035892	C2 domain superfamily	Homologous Superfamily
A	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily
B	IPR036028	SH3-like domain superfamily	Homologous Superfamily
B	IPR008936	Rho GTPase activation protein	Homologous Superfamily
B	IPR035020	PI3K p85 subunit, C-terminal SH2 domain	Domain
B	IPR035591	Phosphatidylinositol 3-kinase regulatory subunit alpha, SH3 domain	Domain
B	IPR032498	PI3K regulatory subunit p85-related , inter-SH2 domain	Domain
B	IPR001452	SH3 domain	Domain
B	IPR035022	PI3K p85 subunit, N-terminal SH2 domain	Domain
B	IPR036860	SH2 domain superfamily	Homologous Superfamily
B	IPR000980	SH2 domain	Domain
B	IPR000198	Rho GTPase-activating protein domain	Domain
B	IPR044124	PIK3R1, inter-SH2 domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P42336	seborrheic keratosis squamous cell carcinoma ovarian cancer CLOVES syndrome Cowden disease colorectal cancer Cowden syndrome 5 renal cell carcinoma megalencephaly-capillary malformation-polymicrogyria syndrome nevus, epidermal cancer head and neck squamous cell carcinoma diffuse large B-cell lymphoma nasopharyngeal carcinoma esophageal adenocarcinoma seborrheic keratosis squamous cell carcinoma ovarian cancer CLOVES syndrome Cowden disease colorectal cancer Cowden syndrome 5 renal cell carcinoma megalencephaly-capillary malformation-polymicrogyria syndrome nevus, epidermal cancer head and neck squamous cell carcinoma diffuse large B-cell lymphoma nasopharyngeal carcinoma esophageal adenocarcinoma hepatocellular carcinoma skin basal cell carcinoma lung cancer papillary renal cell carcinoma adenocarcinoma salivary gland adenoid cystic carcinoma Mouth Neoplasms hyperplasia gastric cancer prostate cancer sarcoma hereditary diffuse gastric adenocarcinoma adenoid cystic carcinoma breast adenocarcinoma tubular adenocarcinoma breast carcinoma chromophobe renal cell carcinoma collecting duct carcinoma penile neoplasm granular cell carcinoma sarcomatoid renal cell carcinoma spindle cell sarcoma breast cancer clear cell renal carcinoma ovarian disease gastric neoplasm colon carcinoma glioblastoma colorectal carcinoma polydactyly head and neck neoplasm psoriasis hepatoblastoma hereditary breast carcinoma cutaneous melanoma schizophrenia skin pigmented basal cell carcinoma angioosteohypertrophic syndrome benign neoplasm of stomach endometriosis thyroid gland carcinoma invasive ductal breast carcinoma epithelioid sarcoma uterine disease large cell medulloblastoma non-small cell lung carcinoma fetal alcohol spectrum disorder lung adenocarcinoma cholangiocarcinoma lung carcinoma ovarian epithelial tumor genetic endocrine growth disease Lynch syndrome colorectal adenocarcinoma penile cancer glioma head and neck cancer renal carcinoma cribriform carcinoma megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1 atypical teratoid rhabdoid tumor IgA glomerulonephritis inverted follicular keratosis liver cancer cerebral cortical dysplasia oral cavity neoplasm fetal alcohol syndrome lung benign neoplasm ovarian carcinoma gastric carcinoma lung disease ovarian neoplasm head and neck carcinoma hemimegalencephaly cribriform carcinoma of breast hereditary hemorrhagic telangiectasia adult hepatocellular carcinoma melanoma digestive system disease hydrocephalus B-cell chronic lymphocytic leukemia ductal breast carcinoma in situ stomach carcinoma in situ intellectual disability urinary bladder cancer juvenile dermatomyositis breast disease familial prostate carcinoma cerebrovascular disorder oral cavity squamous cell carcinoma follicular lymphoma
B	Pharos: P27986	SHORT syndrome immunodeficiency 36 agammaglobulinemia 7, autosomal recessive Burkitt lymphoma cancer prostate cancer glioblastoma Insulin Resistance carcinoma sarcomatoid carcinoma dermatomyositis primitive neuroectodermal tumor Gaucher disease psoriasis intellectual disability SHORT syndrome immunodeficiency 36 agammaglobulinemia 7, autosomal recessive Burkitt lymphoma cancer prostate cancer glioblastoma Insulin Resistance carcinoma sarcomatoid carcinoma dermatomyositis primitive neuroectodermal tumor Gaucher disease psoriasis intellectual disability vitiligo juvenile dermatomyositis agammaglobulinemia lung cancer atypical teratoid rhabdoid tumor medulloblastoma breast cancer oligodendroglioma ovarian carcinoma colorectal adenocarcinoma Pick disease ductal breast carcinoma in situ rheumatoid arthritis tuberculosis interstitial cystitis activated PI3K-delta syndrome large cell medulloblastoma mammary neoplasms, animal autosomal agammaglobulinemia breast carcinoma osteosarcoma ovarian neoplasm cystic fibrosis pituitary cancer exocrine pancreatic carcinoma glioma undifferentiated carcinoma invasive ductal breast carcinoma lung adenocarcinoma malignant pancreatic neoplasm atrial fibrillation autosomal recessive agammaglobulinemia 1 non-small cell lung carcinoma ovarian cancer Parkinson disease

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.

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8W9A

CryoEM structure of human PI3K-alpha (P85/P110-H1047R) with QR-7909 binding at an allosteric site

External Resource: Annotation

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

InterPro: Protein Family Classification InterPro Database Homepage

Pharos: Disease Associations Pharos Homepage Annotation