8RK2

Human Replication protein A (RPA; trimeric core) - ssDNA complex

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Replication protein A 70 kDa DNA-binding subunit, N-terminally processed	chromatin-protein adaptor activity protein-macromolecule adaptor activity molecular adaptor activity DNA binding binding organic cyclic compound binding damaged DNA binding nucleic acid binding sequence-specific DNA binding G-rich strand telomeric DNA binding sequence-specific single stranded DNA binding single-stranded telomeric DNA binding single-stranded DNA binding telomeric DNA binding chromatin-protein adaptor activity protein-macromolecule adaptor activity molecular adaptor activity DNA binding binding organic cyclic compound binding damaged DNA binding nucleic acid binding sequence-specific DNA binding G-rich strand telomeric DNA binding sequence-specific single stranded DNA binding single-stranded telomeric DNA binding single-stranded DNA binding telomeric DNA binding cation binding ion binding metal ion binding small molecule binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process protein localization localization cellular localization protein localization to chromosome protein localization to organelle cellular macromolecule localization macromolecule localization cellular biosynthetic process telomere organization RNA-templated DNA biosynthetic process telomere maintenance via telomere lengthening cellular component organization nucleic acid biosynthetic process organic substance biosynthetic process cellular component organization or biogenesis telomere maintenance via telomerase cellular metabolic process chromosome organization nucleobase-containing compound biosynthetic process macromolecule biosynthetic process telomere maintenance organelle organization biosynthetic process organic cyclic compound biosynthetic process DNA biosynthetic process mismatch repair DNA repair DNA-templated DNA replication protein localization to site of double-strand break DNA recombination double-strand break repair recombinational repair double-strand break repair via homologous recombination base-excision repair nucleotide-excision repair sexual reproduction reproductive process meiotic cell cycle cell cycle	membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular organelle lumen intracellular organelle nuclear replisome replication fork non-membrane-bounded organelle DNA replication factor A complex membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular organelle lumen intracellular organelle nuclear replisome replication fork non-membrane-bounded organelle DNA replication factor A complex protein-DNA complex nuclear replication fork intracellular membrane-bounded organelle cellular anatomical entity organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen replisome nucleoplasm site of double-strand break site of DNA damage chromosome, telomeric region chromosomal region nuclear body PML body
B	Replication protein A 32 kDa subunit	sequence-specific DNA binding DNA binding binding organic cyclic compound binding nucleic acid binding telomeric DNA binding damaged DNA binding protein phosphatase binding phosphatase binding protein binding enzyme binding G-rich strand telomeric DNA binding sequence-specific single stranded DNA binding single-stranded telomeric DNA binding sequence-specific DNA binding DNA binding binding organic cyclic compound binding nucleic acid binding telomeric DNA binding damaged DNA binding protein phosphatase binding phosphatase binding protein binding enzyme binding G-rich strand telomeric DNA binding sequence-specific single stranded DNA binding single-stranded telomeric DNA binding single-stranded DNA binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding	nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process cellular response to stimulus regulation of DNA recombination regulation of cellular process regulation of double-strand break repair response to stimulus nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process cellular response to stimulus regulation of DNA recombination regulation of cellular process regulation of double-strand break repair response to stimulus regulation of cellular response to stress regulation of primary metabolic process cellular response to stress response to stress regulation of response to stress recombinational repair regulation of nucleobase-containing compound metabolic process double-strand break repair via homologous recombination DNA repair double-strand break repair regulation of biological process DNA recombination biological regulation regulation of macromolecule metabolic process regulation of DNA repair regulation of double-strand break repair via homologous recombination DNA damage response regulation of response to stimulus cellular process regulation of metabolic process regulation of DNA metabolic process protein localization localization cellular localization protein localization to chromosome protein localization to organelle cellular macromolecule localization macromolecule localization mismatch repair regulation of cell cycle phase transition DNA damage checkpoint signaling signaling negative regulation of biological process negative regulation of cell cycle cell cycle phase transition regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition intracellular signal transduction mitotic cell cycle negative regulation of mitotic cell cycle cell communication regulation of mitotic cell cycle mitotic DNA integrity checkpoint signaling mitotic DNA damage checkpoint signaling negative regulation of cellular process negative regulation of cell cycle phase transition signal transduction cell cycle regulation of cell cycle cell cycle process negative regulation of G1/S transition of mitotic cell cycle mitotic G1/S transition checkpoint signaling negative regulation of mitotic cell cycle phase transition regulation of cell cycle process negative regulation of cell cycle G1/S phase transition DNA integrity checkpoint signaling negative regulation of cell cycle process cell cycle checkpoint signaling regulation of mitotic cell cycle phase transition mitotic cell cycle checkpoint signaling mitotic G1 DNA damage checkpoint signaling mitotic cell cycle process regulation of G1/S transition of mitotic cell cycle signal transduction in response to DNA damage G1/S transition of mitotic cell cycle mitotic cell cycle phase transition regulation of signal transduction regulation of cell cycle checkpoint regulation of intracellular signal transduction regulation of signaling regulation of cell communication regulation of DNA damage checkpoint telomere organization chromosome organization telomere maintenance cellular component organization organelle organization cellular component organization or biogenesis base-excision repair nucleotide-excision repair	membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular organelle lumen intracellular organelle nuclear replisome replication fork non-membrane-bounded organelle DNA replication factor A complex membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular organelle lumen intracellular organelle nuclear replisome replication fork non-membrane-bounded organelle DNA replication factor A complex protein-DNA complex nuclear replication fork intracellular membrane-bounded organelle cellular anatomical entity organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen replisome nucleoplasm chromatin nuclear body chromosome, telomeric region chromosomal region PML body
C	Replication protein A 14 kDa subunit	DNA binding binding organic cyclic compound binding damaged DNA binding nucleic acid binding single-stranded DNA binding	nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process regulation of mitotic cell cycle regulation of biological process regulation of cellular process biological regulation cellular process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process regulation of mitotic cell cycle regulation of biological process regulation of cellular process biological regulation cellular process cell cycle regulation of cell cycle mitotic cell cycle cellular response to stimulus double-strand break repair response to stimulus DNA recombination cellular response to stress DNA damage response response to stress recombinational repair double-strand break repair via homologous recombination DNA repair base-excision repair mismatch repair cell population proliferation regulation of cell population proliferation nucleotide-excision repair telomere organization chromosome organization telomere maintenance cellular component organization organelle organization cellular component organization or biogenesis	membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular organelle lumen intracellular organelle nuclear replisome replication fork non-membrane-bounded organelle DNA replication factor A complex membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular organelle lumen intracellular organelle nuclear replisome replication fork non-membrane-bounded organelle DNA replication factor A complex protein-DNA complex nuclear replication fork intracellular membrane-bounded organelle cellular anatomical entity organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen replisome site of double-strand break site of DNA damage nucleoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR007199	Replication factor-A protein 1, N-terminal	Domain
A	IPR047192	Replication factor A, C-terminal, eukaryotes	Domain
A	IPR013955	Replication factor A, C-terminal	Domain
A	IPR031657	Replication protein A, OB domain	Domain
A	IPR004365	OB-fold nucleic acid binding domain, AA-tRNA synthetase-type	Domain
A	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
A	IPR004591	Replication factor A protein 1	Family
B	IPR014892	Replication protein A, C-terminal	Domain
B	IPR040260	Replication factor A protein-like	Family
B	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
B	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
B	IPR014646	Replication factor A protein 2	Family
B	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
C	IPR013970	Replication factor A protein 3	Family
C	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P27694	Chloracne astrocytic tumor breast cancer glioblastoma malignant ependymoma ovarian cancer atypical teratoid rhabdoid tumor Hodgkins lymphoma malignant mesothelioma psoriasis B-cell chronic lymphocytic leukemia dermatomyositis lymphoplasmacytic lymphoma medulloblastoma
B	Pharos: P15927	diabetes mellitus lymphoplasmacytic lymphoma ovarian cancer
C	Pharos: P35244	breast cancer ovarian cancer lung cancer pancreatic intraductal papillary-mucinous neoplasm malignant mesothelioma Stevens-Johnson syndrome

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.