8P8X
Crystal structure of a pathogenic mutant variant of human mitochodnrial PheRS
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | PF03147 | e8p8xA2 | A: a+b two layers | X: Alpha-beta plaits | H: Anticodon-binding domain of PheRS (From Topology) | T: Anticodon-binding domain of PheRS | F: PF03147 | ECOD (1.6) |
A | PF01409 | e8p8xA1 | A: a+b three layers | X: Class II aaRS and biotin synthetases (From Topology) | H: Class II aaRS and biotin synthetases (From Topology) | T: Class II aaRS and biotin synthetases | F: PF01409 | ECOD (1.6) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF01409 | tRNA synthetases class II core domain (F) (tRNA-synt_2d) | tRNA synthetases class II core domain (F) | Other tRNA synthetase sub-families are too dissimilar to be included. This family includes only phenylalanyl-tRNA synthetases. This is the core catalytic domain. | Domain | |
PF03147 | Ferredoxin-fold anticodon binding domain (FDX-ACB) | Ferredoxin-fold anticodon binding domain | This is the anticodon binding domain found in some phenylalanyl tRNA synthetases. The domain has a ferredoxin fold [1,2]. | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR045864 | Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) | Homologous Superfamily | |
IPR002319 | Phenylalanyl-tRNA synthetase | Domain | |
IPR004530 | Phenylalanyl-tRNA synthetase, class IIc, mitochondrial | Family | |
IPR006195 | Aminoacyl-tRNA synthetase, class II | Domain | |
IPR005121 | Ferrodoxin-fold anticodon-binding domain | Domain | |
IPR036690 | Ferrodoxin-fold anticodon-binding domain superfamily | Homologous Superfamily |