Annotations: 8JCA

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Ras-like P-loop GTPases	8061451	3002022	SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00025	ADP-ribosylation factor family (Arf)	ADP-ribosylation factor family	Pfam combines a number of different Prosite families together	Domain
B	PF02759	RUN domain (RUN)	RUN domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	ADP-ribosylation factor-like protein 8B	binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding organic cyclic compound binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding organic cyclic compound binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cytoskeletal protein binding protein binding tubulin binding alpha-tubulin binding GDP binding pyrophosphatase activity GTPase activity G protein activity ribonucleoside triphosphate phosphatase activity molecular function regulator activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity beta-tubulin binding	exit from host cell biological process involved in interspecies interaction between organisms non-lytic viral release viral process viral exocytosis viral release from host cell viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction membrane organization catabolic process transport macroautophagy membrane fusion exit from host cell biological process involved in interspecies interaction between organisms non-lytic viral release viral process viral exocytosis viral release from host cell viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction membrane organization catabolic process transport macroautophagy membrane fusion organelle membrane fusion cellular metabolic process autophagy establishment of localization vesicle-mediated transport vesicle organization cellular component organization organelle fusion cellular catabolic process localization organelle organization autophagosome-lysosome fusion cellular process metabolic process cellular component organization or biogenesis vesicle fusion process utilizing autophagic mechanism import into cell cellular component biogenesis lysosome organization cellular component assembly phagolysosome assembly phagocytosis vacuole organization organelle assembly lytic vacuole organization phagosome-lysosome fusion phagosome maturation endocytosis cellular localization anterograde axonal transport intracellular transport axonal transport axo-dendritic transport establishment of localization in cell microtubule-based transport transport along microtubule cytoskeleton-dependent intracellular transport microtubule-based movement microtubule-based process cell division cell cycle chromosome segregation cell cycle process organelle localization lysosome localization vacuolar localization protein localization establishment of protein localization nitrogen compound transport organic substance transport protein transport cellular macromolecule localization macromolecule localization antigen processing and presentation antigen processing and presentation of peptide or polysaccharide antigen via MHC class II immune system process antigen processing and presentation of polysaccharide antigen via MHC class II antigen processing and presentation following phagocytosis lymphocyte mediated immunity response to stimulus immune response response to other organism defense response defense response to symbiont response to external stimulus leukocyte mediated cytotoxicity response to biotic stimulus immune effector process defense response to other organism response to stress natural killer cell mediated cytotoxicity innate immune response leukocyte mediated immunity response to external biotic stimulus natural killer cell mediated immunity cell killing regulated exocytosis secretion export from cell calcium ion regulated lysosome exocytosis secretion by cell exocytosis calcium-ion regulated exocytosis endosomal transport late endosome to lysosome transport vacuolar transport lysosomal transport wound healing plasma membrane repair plasma membrane organization response to wounding endomembrane system organization endosome to lysosome transport intracellular cholesterol transport vesicle-mediated cholesterol transport organic hydroxy compound transport intracellular sterol transport sterol transport intracellular lipid transport endosome to lysosome transport of low-density lipoprotein particle lipid localization lipid transport cytosolic transport cholesterol transport	midbody cellular anatomical entity membrane intracellular organelle intracellular anatomical structure cytoskeleton spindle organelle intracellular non-membrane-bounded organelle spindle midzone microtubule cytoskeleton non-membrane-bounded organelle extracellular exosome membrane-bounded organelle midbody cellular anatomical entity membrane intracellular organelle intracellular anatomical structure cytoskeleton spindle organelle intracellular non-membrane-bounded organelle spindle midzone microtubule cytoskeleton non-membrane-bounded organelle extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytoplasm cytosol endosome membrane endosome intracellular vesicle late endosome membrane intracellular membrane-bounded organelle endomembrane system cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane late endosome organelle membrane lytic vacuole vacuole lysosome vacuolar membrane lytic vacuole membrane lysosomal membrane cytolytic granule cytolytic granule membrane synapse cell junction neuron projection cytoplasm axon axon cytoplasm neuron projection cytoplasmic region plasma membrane bounded cell projection cytoplasm plasma membrane bounded cell projection cell projection
B	Pleckstrin homology domain-containing family M member 2	cytoskeletal protein binding protein binding binding kinesin binding	lymphocyte mediated immunity biological process involved in interspecies interaction between organisms response to stimulus immune response response to other organism defense response defense response to symbiont response to external stimulus leukocyte mediated cytotoxicity response to biotic stimulus immune effector process immune system process defense response to other organism response to stress natural killer cell mediated cytotoxicity lymphocyte mediated immunity biological process involved in interspecies interaction between organisms response to stimulus immune response response to other organism defense response defense response to symbiont response to external stimulus leukocyte mediated cytotoxicity response to biotic stimulus immune effector process immune system process defense response to other organism response to stress natural killer cell mediated cytotoxicity innate immune response leukocyte mediated immunity cellular process response to external biotic stimulus natural killer cell mediated immunity cell killing protein localization regulation of localization regulation of biological process cellular localization regulation of cellular process regulation of protein localization biological regulation localization regulation of cellular localization cellular macromolecule localization macromolecule localization cellular component organization organelle organization cellular component organization or biogenesis Golgi organization endomembrane system organization organelle localization lysosome localization vacuolar localization	endosome membrane membrane-bounded organelle intracellular anatomical structure membrane endosome intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle endosome membrane membrane-bounded organelle intracellular anatomical structure membrane endosome intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle organelle cytoplasm vesicle organelle membrane vacuolar membrane lytic vacuole vacuole lytic vacuole membrane lysosomal membrane lysosome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A	IPR044154	ADP-ribosylation factor-like protein 8A/8B	Family
A	IPR005225	Small GTP-binding protein domain	Domain
A	IPR006689	Small GTPase superfamily, ARF/SAR type	Family
B	IPR037213	RUN domain superfamily	Homologous Superfamily
B	IPR004012	RUN domain	Domain
B	IPR047327	PLEKHM2, RUN domain	Domain
B	IPR001849	Pleckstrin homology domain	Domain
B	IPR011993	PH-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9NVJ2	atypical teratoid rhabdoid tumor dermatomyositis large cell medulloblastoma medulloblastoma Pick disease tuberculosis breast cancer glioblastoma lymphoplasmacytic lymphoma ovarian cancer plasma cell myeloma breast carcinoma invasive ductal breast carcinoma malignant pancreatic neoplasm pancreatic ductal adenocarcinoma atypical teratoid rhabdoid tumor dermatomyositis large cell medulloblastoma medulloblastoma Pick disease tuberculosis breast cancer glioblastoma lymphoplasmacytic lymphoma ovarian cancer plasma cell myeloma breast carcinoma invasive ductal breast carcinoma malignant pancreatic neoplasm pancreatic ductal adenocarcinoma primitive neuroectodermal tumor
B	Pharos: Q8IWE5	alcoholic pancreatitis malignant ependymoma large cell medulloblastoma medulloblastoma left ventricular noncompaction psoriasis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.