8EG3

Structure of human placental steroid (estrone/DHEA) sulfatase at 2.0 angstrom resolution

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Alkaline phosphatase-like	8038181	3001353	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Arylsulfatase C-terminal domain-like	8055772	3002305	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00884,PF14707	e8eg3A1	A: a/b three-layered sandwiches	X: Alkaline phosphatase-like (From Topology)	H: Alkaline phosphatase-like (From Topology)	T: Alkaline phosphatase-like	F: PF00884,PF14707	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF14707	C-terminal region of aryl-sulfatase (Sulfatase_C)	C-terminal region of aryl-sulfatase	-	Domain
A	PF00884	Sulfatase (Sulfatase)	Sulfatase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Steryl-sulfatase	hydrolase activity, acting on ester bonds steryl-sulfatase activity hydrolase activity catalytic activity sulfuric ester hydrolase activity arylsulfatase activity cation binding ion binding binding metal ion binding small molecule binding	catabolic process lipid catabolic process steroid metabolic process primary metabolic process organic cyclic compound catabolic process organic cyclic compound metabolic process steroid catabolic process organic substance metabolic process metabolic process organic substance catabolic process lipid metabolic process multi-multicellular organism process multicellular organismal process reproductive process catabolic process lipid catabolic process steroid metabolic process primary metabolic process organic cyclic compound catabolic process organic cyclic compound metabolic process steroid catabolic process organic substance metabolic process metabolic process organic substance catabolic process lipid metabolic process multi-multicellular organism process multicellular organismal process reproductive process female pregnancy multi-organism reproductive process developmental process epidermis development anatomical structure development tissue development	membrane cellular anatomical entity membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm intracellular membrane-bounded organelle endomembrane system membrane-enclosed lumen intracellular organelle lumen endoplasmic reticulum lumen organelle lumen membrane cellular anatomical entity membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm intracellular membrane-bounded organelle endomembrane system membrane-enclosed lumen intracellular organelle lumen endoplasmic reticulum lumen organelle lumen endoplasmic reticulum endosome intracellular vesicle cytoplasmic vesicle vesicle cell periphery plasma membrane lytic vacuole vacuole lysosome organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network organelle membrane endoplasmic reticulum membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR024607	Sulfatase, conserved site	Conserved Site
A	IPR000917	Sulfatase, N-terminal	Domain
A	IPR017850	Alkaline-phosphatase-like, core domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P08842	recessive X-linked ichthyosis rheumatoid arthritis syndromic recessive X-linked ichthyosis Inflammation obesity disorder attention deficit hyperactivity disorder, inattentive type large cell medulloblastoma malignant glioma medulloblastoma alcoholic hepatitis nasopharyngeal carcinoma astrocytic tumor osteosarcoma Pick disease psoriasis recessive X-linked ichthyosis rheumatoid arthritis syndromic recessive X-linked ichthyosis Inflammation obesity disorder attention deficit hyperactivity disorder, inattentive type large cell medulloblastoma malignant glioma medulloblastoma alcoholic hepatitis nasopharyngeal carcinoma astrocytic tumor osteosarcoma Pick disease psoriasis ulcerative colitis intellectual disability lung cancer malignant mesothelioma atopic eczema pancreatic intraductal papillary-mucinous neoplasm Crohn disease fatty liver disease transitional cell carcinoma ichthyosis invasive ductal breast carcinoma malignant ependymoma malignant pancreatic neoplasm myopathy Alzheimer disease oligodendroglioma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia primitive neuroectodermal tumor atypical teratoid rhabdoid tumor glioblastoma tuberculosis

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A	OPM				Sulfatase

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A	mpstruc			Estrone Sulfatase

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.