Annotations: 8CR1

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Simibi-like P-loop NTPases	8098162	3002018	SCOP2B (2022-06-29)
C [auth B]	SCOP2B Superfamily	Simibi-like P-loop NTPases	8098162	3002018	SCOP2B (2022-06-29)
B [auth C]	SCOP2B Superfamily	EMC6/GET2-like	8101856	3002721	SCOP2B (2022-06-29)
B [auth C]	SCOP2B Superfamily	YidC transmembrane domain-like	8101854	3002720	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	YidC transmembrane domain-like	8101854	3002720	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	EMC6/GET2-like	8101856	3002721	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF02374	e8cr1A1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF02374	ECOD (1.6)
C [auth B]	PF02374	e8cr1B1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF02374	ECOD (1.6)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C [auth B]	ATPase ASNA1	arsenite transmembrane transporter activity inorganic molecular entity transmembrane transporter activity transporter activity transmembrane transporter activity inorganic anion transmembrane transporter activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding arsenite transmembrane transporter activity inorganic molecular entity transmembrane transporter activity transporter activity transmembrane transporter activity inorganic anion transmembrane transporter activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity protein carrier chaperone membrane insertase activity molecular carrier activity cation binding metal ion binding	protein localization membrane organization cellular localization establishment of protein localization establishment of protein localization to membrane localization within membrane protein localization to membrane endoplasmic reticulum organization establishment of localization cellular component organization localization organelle organization protein localization to organelle cellular macromolecule localization macromolecule localization protein localization membrane organization cellular localization establishment of protein localization establishment of protein localization to membrane localization within membrane protein localization to membrane endoplasmic reticulum organization establishment of localization cellular component organization localization organelle organization protein localization to organelle cellular macromolecule localization macromolecule localization cellular process cellular component organization or biogenesis protein insertion into membrane protein insertion into ER membrane endomembrane system organization tail-anchored membrane protein insertion into ER membrane protein targeting post-translational protein targeting to endoplasmic reticulum membrane protein targeting to membrane establishment of protein localization to organelle establishment of protein localization to endoplasmic reticulum protein localization to endoplasmic reticulum protein targeting to ER	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle protein-containing complex endomembrane system GET complex endoplasmic reticulum cytoplasm endoplasmic reticulum protein-containing complex extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle nucleoplasm organelle subcompartment membrane endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network organelle membrane endoplasmic reticulum membrane
B [auth C], D	Guided entry of tail-anchored proteins factor CAMLG,Guided entry of tail-anchored proteins factor 1,GET2-GET1	ubiquitin protein ligase binding protein binding binding ubiquitin-like protein ligase binding enzyme binding protein-membrane adaptor activity protein-macromolecule adaptor activity molecular adaptor activity	organic substance metabolic process receptor metabolic process metabolic process macromolecule metabolic process receptor recycling cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling biological regulation cell surface receptor protein tyrosine kinase signaling pathway cell communication organic substance metabolic process receptor metabolic process metabolic process macromolecule metabolic process receptor recycling cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling biological regulation cell surface receptor protein tyrosine kinase signaling pathway cell communication ERBB signaling pathway epidermal growth factor receptor signaling pathway cellular process signal transduction enzyme-linked receptor protein signaling pathway regulation of protein stability regulation of biological quality protein stabilization negative regulation of post-translational protein modification regulation of protein modification process negative regulation of biological process regulation of protein ubiquitination regulation of primary metabolic process protein ubiquitination negative regulation of protein modification process protein metabolic process negative regulation of protein ubiquitination regulation of protein modification by small protein conjugation or removal protein modification process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process organonitrogen compound metabolic process negative regulation of protein modification by small protein conjugation or removal regulation of post-translational protein modification regulation of protein metabolic process negative regulation of metabolic process primary metabolic process regulation of macromolecule metabolic process macromolecule modification post-translational protein modification regulation of metabolic process protein modification by small protein conjugation protein modification by small protein conjugation or removal protein localization membrane organization cellular localization establishment of protein localization establishment of protein localization to membrane localization within membrane protein localization to membrane endoplasmic reticulum organization establishment of localization cellular component organization localization organelle organization protein localization to organelle cellular macromolecule localization macromolecule localization cellular component organization or biogenesis protein insertion into membrane protein insertion into ER membrane endomembrane system organization tail-anchored membrane protein insertion into ER membrane transport vesicle-mediated transport multicellular organismal process B cell homeostasis multicellular organismal-level homeostasis leukocyte homeostasis homeostatic process immune system process homeostasis of number of cells lymphocyte homeostasis defense response response to stress catabolic process negative regulation of proteolysis negative regulation of proteolysis involved in protein catabolic process proteolysis involved in protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process regulation of ubiquitin-dependent protein catabolic process negative regulation of protein catabolic process regulation of proteolysis involved in protein catabolic process regulation of proteolysis modification-dependent macromolecule catabolic process proteolysis negative regulation of ubiquitin-dependent protein catabolic process organonitrogen compound catabolic process negative regulation of catabolic process negative regulation of proteasomal ubiquitin-dependent protein catabolic process proteasomal protein catabolic process protein catabolic process regulation of catabolic process regulation of proteasomal ubiquitin-dependent protein catabolic process modification-dependent protein catabolic process negative regulation of proteasomal protein catabolic process regulation of proteasomal protein catabolic process ubiquitin-dependent protein catabolic process organic substance catabolic process regulation of protein catabolic process	membrane cellular anatomical entity membrane-bounded organelle protein-containing complex intracellular anatomical structure intracellular membrane-bounded organelle endomembrane system GET complex intracellular organelle organelle endoplasmic reticulum cytoplasm endoplasmic reticulum protein-containing complex organelle subcompartment membrane cellular anatomical entity membrane-bounded organelle protein-containing complex intracellular anatomical structure intracellular membrane-bounded organelle endomembrane system GET complex intracellular organelle organelle endoplasmic reticulum cytoplasm endoplasmic reticulum protein-containing complex organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network organelle membrane endoplasmic reticulum membrane nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C [auth B]	IPR027542	Arsenical pump ATPase, ArsA/GET3, eukaryotic	Family
A, C [auth B]	IPR016300	Arsenical pump ATPase, ArsA/GET3	Family
A, C [auth B]	IPR025723	Anion-transporting ATPase-like domain	Domain
A, C [auth B]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
B [auth C], D	IPR016719	Guided entry of tail-anchored proteins factor CAMLG	Family
B [auth C], D	IPR028945	Get1 family	Family
B [auth C], D	IPR029012	Helix hairpin bin domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, C [auth B]	Pharos: O43681	exocrine pancreatic carcinoma ovarian cancer pulmonary emphysema lung cancer plasma cell myeloma rheumatoid arthritis malignant pancreatic neoplasm psoriasis
B [auth C], D	Pharos: O00258	ovarian cancer plasma cell myeloma Liver Cirrhosis, Experimental attention deficit hyperactivity disorder, inattentive type exocrine pancreatic carcinoma osteosarcoma cystic fibrosis ovarian cancer Down syndrome malignant pancreatic neoplasm sinusitis

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
B [auth C], D	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
B [auth C], D	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Sec, Translocase, and Insertase Proteins	WRB/CAML/TRC40 (Get1/Get2/Get3) insertase

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.