Annotations: 8BFJ

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF10155	CCR4-NOT transcription complex subunit 11 (CNOT11)	CCR4-NOT transcription complex subunit 11	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	CCR4-NOT transcription complex subunit 11	-	regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process post-transcriptional regulation of gene expression regulation of RNA metabolic process organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological quality RNA catabolic process mRNA catabolic process regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process post-transcriptional regulation of gene expression regulation of RNA metabolic process organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological quality RNA catabolic process mRNA catabolic process regulation of biological process positive regulation of nucleobase-containing compound metabolic process cellular metabolic process negative regulation of metabolic process positive regulation of mRNA metabolic process regulation of cellular metabolic process primary metabolic process negative regulation of cellular biosynthetic process nucleobase-containing compound catabolic process nuclear-transcribed mRNA poly(A) tail shortening positive regulation of RNA metabolic process regulation of gene expression organic cyclic compound metabolic process negative regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process nucleic acid catabolic process regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay catabolic process cellular biosynthetic process positive regulation of biological process RNA metabolic process macromolecule catabolic process mRNA destabilization organic substance metabolic process regulation of mRNA catabolic process negative regulation of cellular process negative regulation of macromolecule metabolic process regulation of biosynthetic process nuclear-transcribed mRNA catabolic process RNA destabilization biological regulation regulation of macromolecule metabolic process regulation of catabolic process gene expression macromolecule biosynthetic process mRNA metabolic process nucleic acid metabolic process organic cyclic compound catabolic process regulation of cellular biosynthetic process positive regulation of catabolic process regulation of mRNA stability negative regulation of biosynthetic process positive regulation of mRNA catabolic process regulation of RNA stability cellular process regulation of mRNA metabolic process organic substance catabolic process regulatory ncRNA-mediated gene silencing organonitrogen compound biosynthetic process protein metabolic process organonitrogen compound metabolic process regulation of protein metabolic process translation regulation of translation	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol CCR4-NOT complex protein-containing complex intracellular protein-containing complex membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle
B	Gametogenetin-binding protein 2	-	developmental process spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation cellular developmental process cell differentiation cellular process cellular response to stimulus regulation of cellular process response to stimulus developmental process spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation cellular developmental process cell differentiation cellular process cellular response to stimulus regulation of cellular process response to stimulus negative regulation of biological process regulation of signal transduction negative regulation of cellular metabolic process cell communication regulation of primary metabolic process regulation of phosphate metabolic process peptidyl-amino acid modification phosphate-containing compound metabolic process negative regulation of protein modification process regulation of receptor signaling pathway via JAK-STAT signal transduction protein modification process phosphorus metabolic process negative regulation of protein metabolic process tyrosine phosphorylation of STAT protein regulation of biological process negative regulation of receptor signaling pathway via JAK-STAT protein phosphorylation phosphorylation cellular metabolic process regulation of protein metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process regulation of response to stimulus negative regulation of protein phosphorylation macromolecule modification metabolic process regulation of phosphorus metabolic process macromolecule metabolic process regulation of receptor signaling pathway via STAT regulation of metabolic process cell surface receptor signaling pathway via STAT regulation of protein modification process signaling regulation of protein phosphorylation negative regulation of signaling negative regulation of phosphate metabolic process peptidyl-tyrosine modification negative regulation of cell communication organic substance metabolic process negative regulation of cellular process protein metabolic process negative regulation of macromolecule metabolic process negative regulation of peptidyl-tyrosine phosphorylation regulation of signaling organonitrogen compound metabolic process cell surface receptor signaling pathway regulation of tyrosine phosphorylation of STAT protein negative regulation of response to stimulus biological regulation regulation of peptidyl-tyrosine phosphorylation regulation of macromolecule metabolic process negative regulation of signal transduction negative regulation of tyrosine phosphorylation of STAT protein negative regulation of phosphorus metabolic process regulation of cell communication regulation of phosphorylation negative regulation of phosphorylation peptidyl-tyrosine phosphorylation negative regulation of receptor signaling pathway via STAT cell surface receptor signaling pathway via JAK-STAT labyrinthine layer blood vessel development placenta blood vessel development multicellular organismal process placenta development chordate embryonic development animal organ development labyrinthine layer development embryo development in utero embryonic development vasculature development circulatory system development multicellular organism development embryonic placenta development embryo development ending in birth or egg hatching anatomical structure development embryonic organ development blood vessel development system development cellular biosynthetic process organic substance biosynthetic process regulation of biosynthetic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation regulation of peptidyl-serine phosphorylation negative regulation of peptidyl-serine phosphorylation negative regulation of peptidyl-serine phosphorylation of STAT protein serine phosphorylation of STAT protein regulation of peptidyl-serine phosphorylation of STAT protein peptidyl-serine modification peptidyl-serine phosphorylation	membrane-bounded organelle intracellular organelle intracellular anatomical structure cytoplasmic vesicle organelle intracellular vesicle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle vesicle nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR019312	CCR4-NOT transcription complex subunit 11	Family
B	IPR026073	Gametogenetin-binding protein 2	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9UKZ1	osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia pancreatic intraductal papillary-mucinous carcinoma pancreatic intraductal papillary-mucinous neoplasm
B	Pharos: Q9H3C7	astrocytic tumor hepatocellular carcinoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia Sjogren syndrome chronic kidney disease myopathy ovarian cancer plasma cell myeloma Tourette syndrome dermatomyositis oligodendroglioma pancreatic ductal adenocarcinoma rheumatoid arthritis tuberculosis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.