Annotations: 8ATH

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01299	e8athA1	A: beta meanders	X: lysosome-associated membrane protein LAMP-3 (From Topology)	H: lysosome-associated membrane protein LAMP-3 (From Topology)	T: lysosome-associated membrane protein LAMP-3	F: PF01299	ECOD (1.6)
B	PF01299	e8athB1	A: beta meanders	X: lysosome-associated membrane protein LAMP-3 (From Topology)	H: lysosome-associated membrane protein LAMP-3 (From Topology)	T: lysosome-associated membrane protein LAMP-3	F: PF01299	ECOD (1.6)
C [auth E]	PF07654	e8athE2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
C [auth E]	PF07686	e8athE1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
E [auth H]	PF07654	e8athH2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
E [auth H]	PF07686	e8athH1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
D [auth F]	PF07654	e8athF2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
D [auth F]	PF07686	e8athF1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
F [auth L]	PF07654	e8athL1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
F [auth L]	PF07686	e8athL2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
C [auth E], E [auth H]	Heavy Chain	IGHV1	-	lysosome-associated membrane glycoprotein 1	SAbDab (2024-05-31)
D [auth F], F [auth L]	Light Chain	IGKV19	Kappa	lysosome-associated membrane glycoprotein 1	SAbDab (2024-05-31)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF01299	Lysosome-associated membrane glycoprotein 2-like, luminal domains (Lamp2-like_luminal)	Lysosome-associated membrane glycoprotein 2-like, luminal domains	This domain is found in a group of animal proteins that includes Lysosome-associated membrane glycoprotein 2 from humans (Lamp2). Lamp2 is an integral membrane protein that plays an important role in chaperone-mediated autophagy (CMA), targeting pert ...	This domain is found in a group of animal proteins that includes Lysosome-associated membrane glycoprotein 2 from humans (Lamp2). Lamp2 is an integral membrane protein that plays an important role in chaperone-mediated autophagy (CMA), targeting pertinent proteins for lysosomal degradation. This protein is organised into two conserved luminal domains (this entry), a single transmembrane (TM) domain (Pfam:PF21222), and a short C-terminal cytosolic tail. It adopts a trimeric configuration [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Lysosome-associated membrane glycoprotein 1	protein binding binding virus receptor activity exogenous protein binding protein domain specific binding molecular function inhibitor activity channel regulator activity transporter inhibitor activity ion channel inhibitor activity ion channel regulator activity molecular function regulator activity transporter regulator activity channel inhibitor activity enzyme binding	regulation of immune effector process lymphocyte mediated immunity positive regulation of leukocyte mediated immunity positive regulation of response to biotic stimulus regulation of cellular process response to stimulus response to biotic stimulus positive regulation of leukocyte mediated cytotoxicity positive regulation of immune response positive regulation of natural killer cell mediated immunity leukocyte mediated immunity regulation of immune system process natural killer cell mediated immunity positive regulation of immune system process regulation of immune effector process lymphocyte mediated immunity positive regulation of leukocyte mediated immunity positive regulation of response to biotic stimulus regulation of cellular process response to stimulus response to biotic stimulus positive regulation of leukocyte mediated cytotoxicity positive regulation of immune response positive regulation of natural killer cell mediated immunity leukocyte mediated immunity regulation of immune system process natural killer cell mediated immunity positive regulation of immune system process regulation of biological process regulation of natural killer cell mediated immunity immune response response to other organism regulation of innate immune response response to external stimulus leukocyte mediated cytotoxicity immune effector process regulation of leukocyte mediated immunity regulation of response to stimulus defense response to other organism positive regulation of defense response natural killer cell mediated cytotoxicity regulation of immune response positive regulation of natural killer cell mediated cytotoxicity regulation of cell killing positive regulation of cell killing regulation of defense response regulation of response to biotic stimulus regulation of natural killer cell mediated cytotoxicity biological process involved in interspecies interaction between organisms regulation of response to external stimulus positive regulation of lymphocyte mediated immunity positive regulation of biological process positive regulation of response to stimulus positive regulation of response to external stimulus response to stress regulation of response to stress innate immune response positive regulation of immune effector process response to external biotic stimulus positive regulation of cellular process positive regulation of innate immune response defense response regulation of leukocyte mediated cytotoxicity biological regulation defense response to symbiont regulation of lymphocyte mediated immunity immune system process cellular process cell killing regulation of protein stability regulation of biological quality protein stabilization cellular response to stimulus signaling granzyme-mediated programmed cell death signaling pathway cell death cell communication signal transduction programmed cell death cellular localization post-Golgi vesicle-mediated transport transport intracellular transport lysosomal transport establishment of localization vesicle-mediated transport localization Golgi to vacuole transport cytosolic transport establishment of localization in cell vacuolar transport Golgi to lysosome transport Golgi vesicle transport homeostatic process intracellular pH reduction regulation of intracellular pH cellular component organization lysosome organization vacuolar acidification lysosomal lumen acidification intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis intracellular chemical homeostasis cellular component organization or biogenesis monoatomic cation homeostasis regulation of lysosomal lumen pH regulation of cellular pH intracellular monoatomic ion homeostasis vacuole organization lytic vacuole organization organelle organization cellular homeostasis chemical homeostasis establishment of organelle localization regulation of localization organelle transport along microtubule organelle localization transport along microtubule regulation of intracellular transport regulation of transport regulation of microtubule-based process regulation of microtubule-based movement regulation of organelle transport along microtubule regulation of cellular localization microtubule-based transport cytoskeleton-dependent intracellular transport microtubule-based movement microtubule-based process multicellular organismal process regulated exocytosis cell activation involved in immune response leukocyte degranulation positive regulation of leukocyte degranulation positive regulation of regulated secretory pathway natural killer cell activation regulation of secretion positive regulation of natural killer cell degranulation regulation of natural killer cell degranulation exocytosis natural killer cell degranulation positive regulation of secretion by cell lymphocyte activation positive regulation of exocytosis leukocyte activation regulation of regulated secretory pathway secretion by cell regulation of secretion by cell positive regulation of secretion natural killer cell activation involved in immune response leukocyte activation involved in immune response regulation of leukocyte degranulation lymphocyte activation involved in immune response secretion cell activation export from cell regulation of vesicle-mediated transport positive regulation of transport regulation of exocytosis protein localization establishment of protein localization establishment of protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to organelle	cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane membrane-bounded organelle intracellular anatomical structure pigment granule intracellular vesicle intracellular membrane-bounded organelle intracellular organelle melanosome cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane membrane-bounded organelle intracellular anatomical structure pigment granule intracellular vesicle intracellular membrane-bounded organelle intracellular organelle melanosome cytoplasmic vesicle organelle cytoplasm vesicle extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle lytic vacuole endomembrane system bounding membrane of organelle vesicle membrane lysosome vacuolar membrane azurophil granule vacuole lytic vacuole membrane cytoplasmic vesicle membrane lysosomal membrane secretory granule primary lysosome secretory vesicle azurophil granule membrane organelle membrane secretory granule membrane cytosol sarcolemma phagolysosome endocytic vesicle membrane endocytic vesicle phagolysosome membrane phagocytic vesicle phagocytic vesicle membrane secondary lysosome endosome membrane endosome late endosome membrane late endosome multivesicular body autophagosome membrane autophagosome cytolytic granule cytolytic granule membrane ficolin-1-rich granule membrane ficolin-1-rich granule tertiary granule perinuclear region of cytoplasm autolysosome transport vesicle synapse presynapse synaptic vesicle cell junction exocytic vesicle
C [auth E], E [auth H]	Fab B Heavy Chain	-	-	-
D [auth F], F [auth L]	Fab B Light Chain	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR048524	Lysosome-associated membrane glycoprotein 2-like, transmembrane domain	Domain
A, B	IPR002000	Lysosome-associated membrane glycoprotein	Family
A, B	IPR048528	Lysosome-associated membrane glycoprotein 2-like, luminal domains	Domain
A, B	IPR018134	Lysosome-associated membrane glycoprotein, conserved site	Conserved Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P11279	myopathy pilocytic astrocytoma astrocytic tumor Becker muscular dystrophy cancer Duchenne muscular dystrophy gastric cancer limb-girdle muscular dystrophy malignant ependymoma osteosarcoma plasma cell myeloma atrial fibrillation brain aneurysm dermatomyositis Emery-Dreifuss muscular dystrophy myopathy pilocytic astrocytoma astrocytic tumor Becker muscular dystrophy cancer Duchenne muscular dystrophy gastric cancer limb-girdle muscular dystrophy malignant ependymoma osteosarcoma plasma cell myeloma atrial fibrillation brain aneurysm dermatomyositis Emery-Dreifuss muscular dystrophy gastric carcinoma lung adenocarcinoma malignant pancreatic neoplasm ovarian cancer psoriasis atypical teratoid rhabdoid tumor breast cancer Down syndrome exocrine pancreatic carcinoma juvenile dermatomyositis lymphoplasmacytic lymphoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.