7ZYH

Crystal structure of human CPSF30 in complex with hFip1

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
J	PF00642	e7zyhJ1	A: few secondary structure elements	X: CCCH zinc finger	H: CCCH zinc finger (From Topology)	T: CCCH zinc finger	F: PF00642	ECOD (1.6)
A	PF00642	e7zyhA1	A: few secondary structure elements	X: CCCH zinc finger	H: CCCH zinc finger (From Topology)	T: CCCH zinc finger	F: PF00642	ECOD (1.6)
D	PF00642	e7zyhD1	A: few secondary structure elements	X: CCCH zinc finger	H: CCCH zinc finger (From Topology)	T: CCCH zinc finger	F: PF00642	ECOD (1.6)
G	PF00642	e7zyhG1	A: few secondary structure elements	X: CCCH zinc finger	H: CCCH zinc finger (From Topology)	T: CCCH zinc finger	F: PF00642	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, D, G, J	PF15663	Zinc-finger containing family (zf-CCCH_3)	Zinc-finger containing family	-	Family
A, D, G, J	PF00642	Zinc finger C-x8-C-x5-C-x3-H type (and similar) (zf-CCCH)	Zinc finger C-x8-C-x5-C-x3-H type (and similar)	-	Family
B, C, E, F, H B, C, E, F, H, I, K, L	PF05182	Fip1 motif (Fip1)	Fip1 motif	-	Motif

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, D, G, J	Cleavage and polyadenylation specificity factor subunit 4	cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding RNA binding organic cyclic compound binding nucleic acid binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding	cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process macromolecule metabolic process RNA processing	membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle intracellular membrane-bounded organelle cellular anatomical entity protein-containing complex nucleus nuclear protein-containing complex mRNA cleavage and polyadenylation specificity factor complex mRNA cleavage factor complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle intracellular membrane-bounded organelle cellular anatomical entity protein-containing complex nucleus nuclear protein-containing complex mRNA cleavage and polyadenylation specificity factor complex mRNA cleavage factor complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
B, C, E, F, H B, C, E, F, H, I, K, L	Isoform 4 of Pre-mRNA 3'-end-processing factor FIP1	RNA binding binding organic cyclic compound binding nucleic acid binding	cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process macromolecule metabolic process RNA processing	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle protein-containing complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle intracellular organelle organelle mRNA cleavage and polyadenylation specificity factor complex mRNA cleavage factor complex membrane-enclosed lumen intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle protein-containing complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle intracellular organelle organelle mRNA cleavage and polyadenylation specificity factor complex mRNA cleavage factor complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, D, G, J	IPR036875	Zinc finger, CCHC-type superfamily	Homologous Superfamily
A, D, G, J	IPR000571	Zinc finger, CCCH-type	Domain
A, D, G, J	IPR036855	Zinc finger, CCCH-type superfamily	Homologous Superfamily
A, D, G, J	IPR041686	Zinc-finger CCCH domain	Domain
A, D, G, J	IPR001878	Zinc finger, CCHC-type	Domain
A, D, G, J	IPR045348	CPSF complex subunit CPSF4-like	Family
B, C, E, F, H B, C, E, F, H, I, K, L	IPR007854	Pre-mRNA polyadenylation factor Fip1 domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, D, G, J	Pharos: O95639	attention deficit hyperactivity disorder, inattentive type
B, C, E, F, H B, C, E, F, H, I, K, L	Pharos: Q6UN15	acute promyelocytic leukemia hypereosinophilic syndrome congestive heart failure idiopathic hypereosinophilic syndrome osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia arterial disorder Eosinophilic leukemia ovarian cancer psoriasis chronic eosinophilic leukemia mastocytosis pancreatic intraductal papillary-mucinous carcinoma uterine corpus leiomyoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.