Annotations: 7XQ5

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00010	e7xq5A1	A: alpha duplicates or obligate multimers	X: HLH-like	H: HLH, helix-loop-helix DNA-binding domain (From Topology)	T: HLH, helix-loop-helix DNA-binding domain	F: PF00010	ECOD (1.6)
B	PF00010	e7xq5B1	A: alpha duplicates or obligate multimers	X: HLH-like	H: HLH, helix-loop-helix DNA-binding domain (From Topology)	T: HLH, helix-loop-helix DNA-binding domain	F: PF00010	ECOD (1.6)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Protein INO4	DNA binding binding organic cyclic compound binding nucleic acid binding protein binding protein dimerization activity	cellular metabolic process lipid biosynthetic process primary metabolic process phospholipid biosynthetic process phospholipid metabolic process organic substance metabolic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process organic substance biosynthetic process cellular lipid metabolic process phosphate-containing compound metabolic process metabolic process cellular process cellular metabolic process lipid biosynthetic process primary metabolic process phospholipid biosynthetic process phospholipid metabolic process organic substance metabolic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process organic substance biosynthetic process cellular lipid metabolic process phosphate-containing compound metabolic process metabolic process cellular process phosphorus metabolic process lipid metabolic process regulation of cellular process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II regulation of biological process positive regulation of nucleobase-containing compound metabolic process regulation of cellular metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process organic cyclic compound metabolic process regulation of gene expression organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process positive regulation of DNA-templated transcription cellular biosynthetic process positive regulation of biological process RNA metabolic process positive regulation of cellular metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of biosynthetic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process	RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle organelle
B	Protein INO2	DNA binding binding organic cyclic compound binding nucleic acid binding protein binding protein dimerization activity	cellular metabolic process lipid biosynthetic process primary metabolic process phospholipid biosynthetic process phospholipid metabolic process organic substance metabolic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process organic substance biosynthetic process cellular lipid metabolic process phosphate-containing compound metabolic process metabolic process cellular process cellular metabolic process lipid biosynthetic process primary metabolic process phospholipid biosynthetic process phospholipid metabolic process organic substance metabolic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process organic substance biosynthetic process cellular lipid metabolic process phosphate-containing compound metabolic process metabolic process cellular process phosphorus metabolic process lipid metabolic process regulation of cellular process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II regulation of biological process positive regulation of nucleobase-containing compound metabolic process regulation of cellular metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process organic cyclic compound metabolic process regulation of gene expression organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process positive regulation of DNA-templated transcription cellular biosynthetic process positive regulation of biological process RNA metabolic process positive regulation of cellular metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of biosynthetic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process	RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle organelle
C	DNA (5'-D(PCPCPTPGPCPAPTPGPTPGPAPAPAPAP*T)-3')	-	-	-
D	DNA (5'-D(GPAPTPTPTPTPCPAPCPAPTPGPCPAP*G)-3')	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain	Domain
A	IPR036638	Helix-loop-helix DNA-binding domain superfamily	Homologous Superfamily
B	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain	Domain
B	IPR036638	Helix-loop-helix DNA-binding domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.