7XKY

Crystal structure of Methanocaldococcus jannaschii two-subunit Fumarate hydratase apo-protein complex

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	FumA C-terminal domain-like	8063854	3000697	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF05681	e7xkyA1	A: a+b three layers	X: Thioredoxin-like	H: Fumarate hydratase N-terminal domain (From Topology)	T: Fumarate hydratase N-terminal domain	F: PF05681	ECOD (1.6)
B	PF05683	e7xkyB1	A: a/b three-layered sandwiches	X: The swivelling beta/beta/alpha domains	H: FumA C-terminal domain-like (From Topology)	T: FumA C-terminal domain-like	F: PF05683	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF05681	Fumarate hydratase (Fumerase) (Fumerase)	Fumarate hydratase (Fumerase)	-	Family
B	PF05683	Fumarase C-terminus (Fumerase_C)	Fumarase C-terminus	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Fumarate hydratase	iron-sulfur cluster binding binding 4 iron, 4 sulfur cluster binding metal cluster binding small molecule binding cation binding ion binding metal ion binding hydro-lyase activity lyase activity catalytic activity L(+)-tartrate dehydratase activity carbon-oxygen lyase activity	metabolic process	-
B	Fumarate hydratase	hydro-lyase activity lyase activity catalytic activity L(+)-tartrate dehydratase activity carbon-oxygen lyase activity	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR004646	Fe-S hydro-lyase, tartrate dehydratase alpha-type, catalytic domain	Domain
B	IPR004647	Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain	Domain
B	IPR036660	Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.