Annotations: 7WSO

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth K]	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8091523	3000071	SCOP2B (2022-06-29)
A [auth K]	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8091521	3000071	SCOP2B (2022-06-29)
C [auth B]	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8091521	3000071	SCOP2B (2022-06-29)
C [auth B]	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8091523	3000071	SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth K], C [auth B]	PF07654	Immunoglobulin C1-set domain (C1-set)	Immunoglobulin C1-set domain	-	Domain
B [auth A]	PF00047	Immunoglobulin domain (ig)	Immunoglobulin domain	Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-prot ...	Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.	Domain
D [auth C]	PF07686	Immunoglobulin V-set domain (V-set)	Immunoglobulin V-set domain	This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth K], C [auth B]	Immunoglobulin heavy constant gamma 1	protein-containing complex binding protein binding binding signaling receptor binding immunoglobulin receptor binding Fc-gamma receptor I complex binding antigen binding	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity response to stimulus myeloid leukocyte mediated immunity inflammatory response to antigenic stimulus response to stress leukocyte mediated immunity antibody-dependent cellular cytotoxicity acute inflammatory response hypersensitivity defense response immune response leukocyte mediated cytotoxicity acute inflammatory response to antigenic stimulus adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity response to stimulus myeloid leukocyte mediated immunity inflammatory response to antigenic stimulus response to stress leukocyte mediated immunity antibody-dependent cellular cytotoxicity acute inflammatory response hypersensitivity defense response immune response leukocyte mediated cytotoxicity acute inflammatory response to antigenic stimulus immunoglobulin mediated immune response adaptive immune response immune effector process type II hypersensitivity immune system process type IIa hypersensitivity B cell mediated immunity cellular process inflammatory response cell killing cellular response to stimulus immune response-regulating cell surface receptor signaling pathway regulation of cellular process signaling positive regulation of biological process cell communication positive regulation of response to stimulus immune response-activating signaling pathway immune response-regulating signaling pathway positive regulation of immune response regulation of immune system process signal transduction positive regulation of immune system process regulation of biological process cell surface receptor signaling pathway immune response-activating cell surface receptor signaling pathway B cell receptor signaling pathway biological regulation regulation of response to stimulus regulation of immune response antigen receptor-mediated signaling pathway activation of immune response humoral immune response complement activation humoral immune response mediated by circulating immunoglobulin complement activation, classical pathway complement-dependent cytotoxicity biological process involved in interspecies interaction between organisms response to other organism antibacterial humoral response defense response to symbiont response to external stimulus antimicrobial humoral response response to biotic stimulus defense response to bacterium defense response to other organism response to bacterium response to external biotic stimulus	extracellular region extracellular space cellular anatomical entity blood microparticle protein-containing complex immunoglobulin complex, circulating immunoglobulin complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle vesicle extracellular membrane-bounded organelle extracellular region extracellular space cellular anatomical entity blood microparticle protein-containing complex immunoglobulin complex, circulating immunoglobulin complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle vesicle extracellular membrane-bounded organelle cell periphery plasma membrane membrane IgG immunoglobulin complex
B [auth A]	B-cell antigen receptor complex-associated protein alpha chain	identical protein binding protein binding binding molecular transducer activity transmembrane signaling receptor activity signaling receptor activity	multicellular organismal process cell population proliferation B cell activation cell activation B cell proliferation lymphocyte activation leukocyte proliferation leukocyte activation immune system process mononuclear cell proliferation lymphocyte proliferation cellular process developmental process cellular developmental process multicellular organismal process cell population proliferation B cell activation cell activation B cell proliferation lymphocyte activation leukocyte proliferation leukocyte activation immune system process mononuclear cell proliferation lymphocyte proliferation cellular process developmental process cellular developmental process hemopoiesis cell development mononuclear cell differentiation lymphocyte differentiation B cell differentiation cell differentiation anatomical structure development leukocyte differentiation cellular response to stimulus immune response-regulating cell surface receptor signaling pathway regulation of cellular process response to stimulus signaling positive regulation of biological process cell communication positive regulation of response to stimulus immune response-activating signaling pathway immune response-regulating signaling pathway positive regulation of immune response regulation of immune system process signal transduction positive regulation of immune system process regulation of biological process cell surface receptor signaling pathway immune response-activating cell surface receptor signaling pathway immune response B cell receptor signaling pathway biological regulation regulation of response to stimulus regulation of immune response antigen receptor-mediated signaling pathway activation of immune response adaptive immune response	cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane protein-containing complex IgM immunoglobulin complex plasma membrane protein complex IgM B cell receptor complex membrane protein complex immunoglobulin complex receptor complex cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane protein-containing complex IgM immunoglobulin complex plasma membrane protein complex IgM B cell receptor complex membrane protein complex immunoglobulin complex receptor complex B cell receptor complex plasma membrane signaling receptor complex membrane microdomain membrane raft membrane-bounded organelle intracellular anatomical structure endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle late endosome cytoplasm multivesicular body vesicle
D [auth C]	B-cell antigen receptor complex-associated protein beta chain	identical protein binding protein binding binding molecular transducer activity transmembrane signaling receptor activity signaling receptor activity	developmental process multicellular organismal process cellular developmental process hemopoiesis B cell activation cell activation cell development mononuclear cell differentiation lymphocyte differentiation lymphocyte activation leukocyte activation B cell differentiation cell differentiation immune system process anatomical structure development developmental process multicellular organismal process cellular developmental process hemopoiesis B cell activation cell activation cell development mononuclear cell differentiation lymphocyte differentiation lymphocyte activation leukocyte activation B cell differentiation cell differentiation immune system process anatomical structure development cellular process leukocyte differentiation cellular response to stimulus immune response-regulating cell surface receptor signaling pathway regulation of cellular process response to stimulus signaling positive regulation of biological process cell communication positive regulation of response to stimulus immune response-activating signaling pathway immune response-regulating signaling pathway positive regulation of immune response regulation of immune system process signal transduction positive regulation of immune system process regulation of biological process cell surface receptor signaling pathway immune response-activating cell surface receptor signaling pathway immune response B cell receptor signaling pathway biological regulation regulation of response to stimulus regulation of immune response antigen receptor-mediated signaling pathway activation of immune response adaptive immune response	cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane protein-containing complex IgM immunoglobulin complex plasma membrane protein complex IgM B cell receptor complex membrane protein complex immunoglobulin complex receptor complex cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane protein-containing complex IgM immunoglobulin complex plasma membrane protein complex IgM B cell receptor complex membrane protein complex immunoglobulin complex receptor complex B cell receptor complex plasma membrane signaling receptor complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth K], C [auth B]	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A [auth K], C [auth B]	IPR003597	Immunoglobulin C1-set	Domain
A [auth K], C [auth B]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A [auth K], C [auth B]	IPR007110	Immunoglobulin-like domain	Domain
A [auth K], C [auth B]	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site	Conserved Site
B [auth A]	IPR039695	B-cell antigen receptor complex-associated protein alpha/beta chain	Family
B [auth A]	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
B [auth A]	IPR003599	Immunoglobulin subtype	Domain
B [auth A]	IPR003598	Immunoglobulin subtype 2	Domain
B [auth A]	IPR013151	Immunoglobulin-like beta-sandwich domain	Domain
B [auth A]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
B [auth A]	IPR007110	Immunoglobulin-like domain	Domain
B [auth A]	IPR003110	Phosphorylated immunoreceptor signalling ITAM	Repeat
D [auth C]	IPR039695	B-cell antigen receptor complex-associated protein alpha/beta chain	Family
D [auth C]	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
D [auth C]	IPR003599	Immunoglobulin subtype	Domain
D [auth C]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
D [auth C]	IPR013106	Immunoglobulin V-set domain	Domain
D [auth C]	IPR007110	Immunoglobulin-like domain	Domain
D [auth C]	IPR003110	Phosphorylated immunoreceptor signalling ITAM	Repeat

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth K], C [auth B]	Pharos: P01857	B-cell chronic lymphocytic leukemia myositis polycystic ovary syndrome plasma cell myeloma plasma cell neoplasm Sclerocystic Ovaries acquired idiopathic inflammatory myopathy lung adenocarcinoma ovarian cancer peripheral neuropathy Sjogren syndrome amyloidosis breast cancer medulloblastoma nasopharyngeal carcinoma B-cell chronic lymphocytic leukemia myositis polycystic ovary syndrome plasma cell myeloma plasma cell neoplasm Sclerocystic Ovaries acquired idiopathic inflammatory myopathy lung adenocarcinoma ovarian cancer peripheral neuropathy Sjogren syndrome amyloidosis breast cancer medulloblastoma nasopharyngeal carcinoma periodontitis interstitial cystitis myeloid neoplasm osteosarcoma peripheral nervous system disease
B [auth A]	Pharos: P11912	agammaglobulinemia diffuse large B-cell lymphoma agammaglobulinemia 3, autosomal recessive autosomal recessive agammaglobulinemia 1 Hypogammaglobulinemia lymphoma osteosarcoma sinusitis cutaneous lupus erythematosus gastric cancer interstitial cystitis non-Hodgkin lymphoma pancreatic intraductal papillary-mucinous carcinoma ulcerative colitis autosomal agammaglobulinemia agammaglobulinemia diffuse large B-cell lymphoma agammaglobulinemia 3, autosomal recessive autosomal recessive agammaglobulinemia 1 Hypogammaglobulinemia lymphoma osteosarcoma sinusitis cutaneous lupus erythematosus gastric cancer interstitial cystitis non-Hodgkin lymphoma pancreatic intraductal papillary-mucinous carcinoma ulcerative colitis autosomal agammaglobulinemia cystic fibrosis gastric carcinoma lung adenocarcinoma non-small cell lung carcinoma periodontitis
D [auth C]	Pharos: P40259	agammaglobulinemia 6, autosomal recessive diffuse large B-cell lymphoma agammaglobulinemia liver disease autosomal recessive agammaglobulinemia 1 Hypogammaglobulinemia non-Hodgkin lymphoma interstitial cystitis lymphoma osteosarcoma autosomal agammaglobulinemia nasopharyngeal carcinoma pituitary cancer

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A [auth K], B [auth A], C [auth B], D [auth C]	OPM	Transmembrane	Bitopic proteins	T-cell and B-cell receptor complexes	B-cell antigen receptor complex

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A [auth K], B [auth A], C [auth B], D [auth C]	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A [auth K], B [auth A], C [auth B], D [auth C]	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	B Cell Receptor Complexes	B-Cell receptor in complex with IgG