7V0M

Local refinement of ankyrin-1 (N-terminal half), class 1 of erythrocyte ankyrin-1 complex

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: mpstruc

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00023	e7v0mA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Ankyrin repeat (From Topology)	T: Ankyrin repeat	F: PF00023	ECOD (1.6)
A	PF13637	e7v0mA2	A: alpha superhelices	X: Repetitive alpha hairpins	H: Ankyrin repeat (From Topology)	T: Ankyrin repeat	F: PF13637	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00023	Ankyrin repeat (Ank)	Ankyrin repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Ankyrin-1	cytoskeletal protein binding spectrin binding protein-containing complex binding protein binding binding protein phosphatase binding phosphatase binding enzyme binding transmembrane transporter binding structural constituent of cytoskeleton structural molecule activity protein-macromolecule adaptor activity cytoskeletal anchor activity molecular adaptor activity cytoskeletal protein binding spectrin binding protein-containing complex binding protein binding binding protein phosphatase binding phosphatase binding enzyme binding transmembrane transporter binding structural constituent of cytoskeleton structural molecule activity protein-macromolecule adaptor activity cytoskeletal anchor activity molecular adaptor activity ATPase binding	positive regulation of organelle organization regulation of biological process positive regulation of cellular component organization regulation of cellular process regulation of cellular component organization biological regulation positive regulation of biological process regulation of organelle organization cellular component organization organelle organization cellular process cellular component organization or biogenesis positive regulation of cellular process protein localization positive regulation of organelle organization regulation of biological process positive regulation of cellular component organization regulation of cellular process regulation of cellular component organization biological regulation positive regulation of biological process regulation of organelle organization cellular component organization organelle organization cellular process cellular component organization or biogenesis positive regulation of cellular process protein localization localization protein localization to cell periphery cellular localization protein localization to plasma membrane cellular macromolecule localization macromolecule localization localization within membrane protein localization to membrane establishment or maintenance of bipolar cell polarity establishment or maintenance of epithelial cell apical/basal polarity maintenance of cell polarity maintenance of epithelial cell apical/basal polarity maintenance of apical/basal cell polarity establishment or maintenance of apical/basal cell polarity establishment or maintenance of cell polarity transport establishment of localization in cell intracellular transport endoplasmic reticulum to Golgi vesicle-mediated transport establishment of localization Golgi vesicle transport vesicle-mediated transport cellular response to stimulus response to stimulus signaling signal transduction cell communication cytoskeleton organization secretion by cell exocytosis secretion export from cell	cell periphery postsynapse postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region cellular anatomical entity synaptic membrane M band intracellular anatomical structure sarcomere intracellular organelle cell periphery postsynapse postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region cellular anatomical entity synaptic membrane M band intracellular anatomical structure sarcomere intracellular organelle organelle intracellular non-membrane-bounded organelle contractile muscle fiber A band cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex non-membrane-bounded organelle Z disc I band ankyrin-1 complex protein-containing complex membrane protein complex cytosol sarcolemma basal part of cell basal plasma membrane basolateral plasma membrane cell projection neuron projection plasma membrane bounded cell projection cytoskeleton axon cell leading edge axolemma leading edge membrane neuron projection membrane main axon cell projection membrane membrane-bounded organelle intracellular membrane-bounded organelle endomembrane system sarcoplasm endoplasmic reticulum sarcoplasmic reticulum spectrin-associated cytoskeleton cytoplasmic side of plasma membrane cytoplasmic side of membrane side of membrane
B [auth W]	Band 3 anion transport protein	cytoskeletal protein binding ankyrin binding protein binding binding hemoglobin binding bicarbonate transmembrane transporter activity transporter activity transmembrane transporter activity organic anion transmembrane transporter activity chloride transmembrane transporter activity monoatomic anion transmembrane transporter activity bicarbonate:monoatomic anion antiporter activity secondary active transmembrane transporter activity antiporter activity cytoskeletal protein binding ankyrin binding protein binding binding hemoglobin binding bicarbonate transmembrane transporter activity transporter activity transmembrane transporter activity organic anion transmembrane transporter activity chloride transmembrane transporter activity monoatomic anion transmembrane transporter activity bicarbonate:monoatomic anion antiporter activity secondary active transmembrane transporter activity antiporter activity active monoatomic ion transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity chloride:bicarbonate antiporter activity monoatomic ion transmembrane transporter activity inorganic anion transmembrane transporter activity solute:inorganic anion antiporter activity protein-membrane adaptor activity protein-macromolecule adaptor activity molecular adaptor activity identical protein binding protein homodimerization activity protein dimerization activity	multicellular organismal process regulation of body fluid levels wound healing response to stimulus hemostasis biological regulation blood coagulation response to stress coagulation regulation of biological quality response to wounding developmental process erythrocyte development cellular developmental process multicellular organismal process regulation of body fluid levels wound healing response to stimulus hemostasis biological regulation blood coagulation response to stress coagulation regulation of biological quality response to wounding developmental process erythrocyte development cellular developmental process homeostatic process hemopoiesis cell development erythrocyte differentiation multicellular organismal-level homeostasis myeloid cell differentiation immune system process cell differentiation anatomical structure development myeloid cell development homeostasis of number of cells cellular process myeloid cell homeostasis erythrocyte homeostasis transport monoatomic ion transmembrane transport inorganic ion transmembrane transport inorganic anion transmembrane transport establishment of localization chloride transport transmembrane transport localization chloride transmembrane transport monoatomic anion transport monoatomic anion transmembrane transport monoatomic ion transport inorganic anion transport cellular homeostasis chemical homeostasis monoatomic ion homeostasis intracellular chemical homeostasis intracellular monoatomic ion homeostasis bicarbonate transport organic anion transport organic substance transport protein localization protein localization to cell periphery cellular localization protein localization to plasma membrane cellular macromolecule localization macromolecule localization localization within membrane protein localization to membrane renal system process system process regulation of urine volume negative regulation of urine volume membrane organization phospholipid translocation lipid localization phospholipid transport lipid transport lipid translocation regulation of membrane lipid distribution plasma membrane phospholipid scrambling cellular component organization plasma membrane organization cellular component organization or biogenesis endomembrane system organization organophosphate ester transport pH elevation regulation of pH monoatomic cation homeostasis pyridine nucleotide catabolic process oxoacid metabolic process carbohydrate catabolic process organophosphate catabolic process carbohydrate derivative metabolic process regulation of generation of precursor metabolites and energy nucleoside phosphate catabolic process organic acid metabolic process regulation of primary metabolic process regulation of ATP metabolic process regulation of purine nucleotide catabolic process negative regulation of nucleotide metabolic process regulation of small molecule metabolic process regulation of nucleotide metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process small molecule metabolic process purine ribonucleotide catabolic process negative regulation of carbohydrate metabolic process nucleoside phosphate metabolic process organonitrogen compound catabolic process pyruvate metabolic process cellular metabolic process negative regulation of metabolic process negative regulation of purine nucleotide catabolic process purine nucleoside diphosphate metabolic process primary metabolic process purine-containing compound catabolic process regulation of purine nucleotide metabolic process nucleobase-containing compound catabolic process nucleoside diphosphate metabolic process metabolic process regulation of phosphorus metabolic process monocarboxylic acid metabolic process pyridine-containing compound catabolic process ribose phosphate metabolic process ATP metabolic process negative regulation of purine nucleotide metabolic process negative regulation of phosphate metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process negative regulation of nucleotide catabolic process purine nucleotide catabolic process carbohydrate derivative catabolic process regulation of glycolytic process through fructose-6-phosphate organic cyclic compound catabolic process purine-containing compound metabolic process ADP metabolic process negative regulation of phosphorus metabolic process purine ribonucleoside diphosphate metabolic process organic substance catabolic process purine ribonucleoside diphosphate catabolic process negative regulation of glycolytic process through fructose-6-phosphate ribonucleotide catabolic process regulation of cellular process negative regulation of small molecule metabolic process negative regulation of glycolytic process negative regulation of biological process negative regulation of ATP metabolic process negative regulation of cellular metabolic process nucleobase-containing compound metabolic process glycolytic process pyridine-containing compound metabolic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process phosphorus metabolic process pyridine nucleotide metabolic process nicotinamide nucleotide metabolic process regulation of carbohydrate catabolic process regulation of biological process regulation of cellular metabolic process nucleotide metabolic process organic cyclic compound metabolic process purine nucleoside diphosphate catabolic process nucleoside diphosphate catabolic process regulation of nucleotide catabolic process nucleoside triphosphate metabolic process purine ribonucleotide metabolic process regulation of metabolic process catabolic process organic substance metabolic process purine nucleotide metabolic process ribonucleotide metabolic process negative regulation of cellular process ribonucleoside diphosphate metabolic process ribonucleoside diphosphate catabolic process regulation of carbohydrate metabolic process nucleotide catabolic process ribonucleoside triphosphate metabolic process negative regulation of catabolic process purine nucleoside triphosphate metabolic process carbohydrate metabolic process organonitrogen compound metabolic process ADP catabolic process carboxylic acid metabolic process regulation of catabolic process generation of precursor metabolites and energy regulation of glycolytic process organophosphate metabolic process glycolytic process through fructose-6-phosphate regulation of intracellular pH intracellular monoatomic cation homeostasis regulation of cellular pH	membrane cellular anatomical entity intracellular anatomical structure Z disc sarcomere intracellular organelle I band organelle intracellular non-membrane-bounded organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer membrane cellular anatomical entity intracellular anatomical structure Z disc sarcomere intracellular organelle I band organelle intracellular non-membrane-bounded organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex non-membrane-bounded organelle ankyrin-1 complex protein-containing complex membrane protein complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cell periphery plasma membrane basal part of cell basal plasma membrane plasma membrane region basolateral plasma membrane blood microparticle cytoplasmic side of plasma membrane cytoplasmic side of membrane side of membrane cell cortex cortical cytoskeleton cytoskeleton

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036770	Ankyrin repeat-containing domain superfamily	Homologous Superfamily
A	IPR040745	Ankyrin, UPA domain	Domain
A	IPR000906	ZU5 domain	Domain
A	IPR002110	Ankyrin repeat	Repeat
A	IPR011029	Death-like domain superfamily	Homologous Superfamily
A	IPR000488	Death domain	Domain
B [auth W]	IPR013769	Band 3 cytoplasmic domain	Domain
B [auth W]	IPR001717	Anion exchange protein	Family
B [auth W]	IPR003020	Bicarbonate transporter, eukaryotic	Family
B [auth W]	IPR011531	Bicarbonate transporter-like, transmembrane domain	Domain
B [auth W]	IPR002977	Anion exchange protein 1	Family
B [auth W]	IPR016152	Phosphotransferase/anion transporter	Homologous Superfamily
B [auth W]	IPR018241	Anion exchange, conserved site	Conserved Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P16157	hereditary spherocytosis hereditary spherocytosis type 1 8p11.2 deletion syndrome Bone Diseases, Developmental familial hemolytic anemia hereditary elliptocytosis pilocytic astrocytoma subependymal giant cell astrocytoma hemolytic anemia myopathy primitive neuroectodermal tumor type 2 diabetes mellitus congenital anemia malignant ependymoma maturity-onset diabetes of the young hereditary spherocytosis hereditary spherocytosis type 1 8p11.2 deletion syndrome Bone Diseases, Developmental familial hemolytic anemia hereditary elliptocytosis pilocytic astrocytoma subependymal giant cell astrocytoma hemolytic anemia myopathy primitive neuroectodermal tumor type 2 diabetes mellitus congenital anemia malignant ependymoma maturity-onset diabetes of the young osteosarcoma atypical teratoid rhabdoid tumor cystic fibrosis glioblastoma malignant glioma medulloblastoma
B [auth W]	Pharos: P02730	hereditary elliptocytosis hereditary spherocytosis renal tubular acidosis hereditary spherocytosis type 4 cryohydrocytosis southeast Asian ovalocytosis hemolytic anemia renal tubular acidosis, distal, 4, with hemolytic anemia malaria hematologic disease Ovalocytosis, Malaysian-Melanesian-Filipino Type autosomal dominant distal renal tubular acidosis familial hemolytic anemia distal renal tubular acidosis MALT lymphoma hereditary elliptocytosis hereditary spherocytosis renal tubular acidosis hereditary spherocytosis type 4 cryohydrocytosis southeast Asian ovalocytosis hemolytic anemia renal tubular acidosis, distal, 4, with hemolytic anemia malaria hematologic disease Ovalocytosis, Malaysian-Melanesian-Filipino Type autosomal dominant distal renal tubular acidosis familial hemolytic anemia distal renal tubular acidosis MALT lymphoma renal tubular acidosis, distal, 3, with or without sensorineural hearing loss tuberculosis psoriasis osteosarcoma

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B [auth W]	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Solute Carrier Family 4 (anion exchanger)	Erythrocyte Band 3 anion exchanger complex. Band 3-Glycophorin A complex, outward facing

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.