Annotations: 7USW

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	F_UNCLASSIFIED	e7uswC1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: F_UNCLASSIFIED	ECOD (1.6)
C	PF13499	e7uswC2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF13499	ECOD (1.6)
E	F_UNCLASSIFIED	e7uswE2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: F_UNCLASSIFIED	ECOD (1.6)
E	PF13499	e7uswE1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF13499	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF07810	TMC domain (TMC)	TMC domain	These sequences are similar to a region conserved amongst various protein products of the transmembrane channel-like (TMC) gene family, such as Transmembrane channel-like protein 3 (Swiss:Q7TN63) and EVIN2 (Swiss:Q8IU68) - this region is termed the T ...	These sequences are similar to a region conserved amongst various protein products of the transmembrane channel-like (TMC) gene family, such as Transmembrane channel-like protein 3 (Swiss:Q7TN63) and EVIN2 (Swiss:Q8IU68) - this region is termed the TMC domain [1]. Mutations in these genes are implicated in a number of human conditions, such as deafness and epidermodysplasia verruciformis [1]. TMC proteins are thought to have important cellular roles, and may be modifiers of ion channels or transporters [2].	Domain
D, F	PF16038	TMIE protein (TMIE)	TMIE protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Transmembrane channel-like protein 1	passive transmembrane transporter activity monoatomic ion channel activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity monoatomic cation transmembrane transporter activity sodium channel activity sodium ion transmembrane transporter activity monoatomic cation channel activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity metal ion transmembrane transporter activity gated channel activity passive transmembrane transporter activity monoatomic ion channel activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity monoatomic cation transmembrane transporter activity sodium channel activity sodium ion transmembrane transporter activity monoatomic cation channel activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity metal ion transmembrane transporter activity gated channel activity mechanosensitive monoatomic ion channel activity	multicellular organismal process system process sensory perception of chemical stimulus sensory perception nervous system process detection of stimulus response to stimulus detection of stimulus involved in sensory perception transmembrane transport localization transport monoatomic ion transmembrane transport monoatomic ion transport cellular process multicellular organismal process system process sensory perception of chemical stimulus sensory perception nervous system process detection of stimulus response to stimulus detection of stimulus involved in sensory perception transmembrane transport localization transport monoatomic ion transmembrane transport monoatomic ion transport cellular process establishment of localization	somatodendritic compartment cell body neuronal cell body cellular anatomical entity cell periphery plasma membrane membrane membrane-bounded organelle non-motile cilium cell projection organelle cilium plasma membrane bounded cell projection
C, E	CALMyrin (Calcium and Integrin Binding protein) homolog	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding calcium ion binding	inorganic ion homeostasis chemical homeostasis homeostatic process monoatomic ion homeostasis calcium ion homeostasis monoatomic cation homeostasis	-
D, F	Transmembrane inner ear expressed protein	-	-	intracellular anatomical structure cellular anatomical entity intracellular organelle organelle intracellular non-membrane-bounded organelle contractile muscle fiber cytoplasm supramolecular fiber supramolecular polymer supramolecular complex striated muscle dense body non-membrane-bounded organelle membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR012496	TMC domain	Domain
A, B	IPR038900	Transmembrane channel-like protein	Family
C, E	IPR002048	EF-hand domain	Domain
C, E	IPR011992	EF-hand domain pair	Homologous Superfamily
D, F	IPR032006	Transmembrane inner ear expressed protein	Family

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, D, F	OPM	Transmembrane	Alpha-helical polytopic	Calcium-activated chloride channel	Transmembrane channel family

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, D, F	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B, D, F	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B, D, F	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Channels: Mechanosensitive	Transmembrane channel-like protein 1 (TMC-1) complex. Expanded conformation

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.