7USM
Integrin alphaM/beta2 ectodomain
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | PF08441 | e7usmA1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF08441 | ECOD (1.6) |
A | PF20805 | e7usmA4 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF20805 | ECOD (1.6) |
A | PF21520 | e7usmA2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF21520 | ECOD (1.6) |
A | PF01839 | e7usmA3 | A: beta duplicates or obligate multimers | X: beta-propeller-like | H: beta-propeller | T: 7-bladed | F: PF01839 | ECOD (1.6) |
B | F_UNCLASSIFIED | e7usmB7 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: F_UNCLASSIFIED | ECOD (1.6) |
B | PF07965 | e7usmB3 | A: a+b two layers | X: Integrin beta tail domain (From Topology) | H: Integrin beta tail domain (From Topology) | T: Integrin beta tail domain | F: PF07965 | ECOD (1.6) |
B | PF00362 | e7usmB2 | A: a/b three-layered sandwiches | X: HAD domain-like | H: HAD domain-related | T: vWA-like | F: PF00362 | ECOD (1.6) |
B | PF17205 | e7usmB1 | A: few secondary structure elements | X: Trefoil/Plexin domain-like (From Topology) | H: Trefoil/Plexin domain-like (From Topology) | T: Trefoil/Plexin domain-like | F: PF17205 | ECOD (1.6) |
B | F_UNCLASSIFIED | e7usmB8 | A: few secondary structure elements | X: EGF-like | H: EGF-related | T: EGF/Laminin | F: F_UNCLASSIFIED | ECOD (1.6) |
B | PF07974 | e7usmB6 | A: few secondary structure elements | X: EGF-like | H: EGF-related | T: EGF/Laminin | F: PF07974 | ECOD (1.6) |
B | PF18372 | e7usmB4 | A: few secondary structure elements | X: EGF-like | H: EGF-related | T: EGF/Laminin | F: PF18372 | ECOD (1.6) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF21520 | Integrin alpha-X-like, Ig-like domain 3 (ITGAX-like_Ig_3) | Integrin alpha-X-like, Ig-like domain 3 | This domain is found in Integrin alpha-X from humans (ITGAX) and similar proteins predominantly found in vertebrates. ITGAX is a receptor for fibrinogen. This region composed of an immunoglobulin-like domain [1,3]. | Domain | |
PF20805 | Integrin alpha Ig-like domain 2 (Integrin_A_Ig_2) | Integrin alpha Ig-like domain 2 | This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of Pfam:PF01839 repeats and to the N-terminus of the Pfam:PF00357 cytoplasmic region. This region is composed of an immunoglobulin-like domain. | Domain | |
PF01839 | FG-GAP repeat (FG-GAP) | FG-GAP repeat | - | Repeat | |
PF08441 | Integrin alpha Ig-like domain 1 (Integrin_A_Ig_1) | Integrin alpha Ig-like domain 1 | This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of Pfam:PF01839 repeats and to the N-terminus of the Pfam:PF00357 cytoplasmic region. This region is composed of an immunoglobulin-like domain. | Domain | |
PF00362 | Integrin beta chain VWA domain (Integrin_beta) | Integrin beta chain VWA domain | Integrins have been found in animals and their homologues have also been found in cyanobacteria, probably due to horizontal gene transfer [1]. This domain corresponds to the integrin beta VWA domain. | Domain | |
PF17205 | Integrin plexin domain (PSI_integrin) | Integrin plexin domain | This short disulphide rich domain is found at the N-terminus of integrin beta chains. | Domain | |
PF07965 | Integrin beta tail domain (Integrin_B_tail) | Integrin beta tail domain | This is the beta tail domain of the Integrin protein. Integrins are receptors which are involved in cell-cell and cell-extracellular matrix interactions. | Domain |