Annotations: 7UPM

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00069	e7upmA1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: PF00069	ECOD (1.6)
B	PF07686	e7upmB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
B	Heavy Chain	IGHV1	-	tribbles homolog 2	SAbDab (2024-05-24)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00069	Protein kinase domain (Pkinase)	Protein kinase domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Tribbles homolog 2	enzyme regulator activity protein kinase inhibitor activity molecular function inhibitor activity molecular function regulator activity enzyme inhibitor activity protein kinase regulator activity kinase inhibitor activity kinase regulator activity protein binding binding kinase binding enzyme binding protein kinase binding mitogen-activated protein kinase kinase binding enzyme regulator activity protein kinase inhibitor activity molecular function inhibitor activity molecular function regulator activity enzyme inhibitor activity protein kinase regulator activity kinase inhibitor activity kinase regulator activity protein binding binding kinase binding enzyme binding protein kinase binding mitogen-activated protein kinase kinase binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding ubiquitin-protein transferase regulator activity ubiquitin protein ligase binding ubiquitin-like protein ligase binding	developmental process fat cell differentiation regulation of biological process regulation of cellular process regulation of developmental process cellular developmental process negative regulation of developmental process biological regulation negative regulation of biological process regulation of cell differentiation negative regulation of fat cell differentiation cell differentiation negative regulation of cellular process negative regulation of cell differentiation developmental process fat cell differentiation regulation of biological process regulation of cellular process regulation of developmental process cellular developmental process negative regulation of developmental process biological regulation negative regulation of biological process regulation of cell differentiation negative regulation of fat cell differentiation cell differentiation negative regulation of cellular process negative regulation of cell differentiation cellular process regulation of fat cell differentiation regulation of catalytic activity negative regulation of catalytic activity regulation of transferase activity negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of kinase activity negative regulation of transferase activity regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of protein modification process phosphorus metabolic process protein modification process negative regulation of protein metabolic process protein phosphorylation phosphorylation cellular metabolic process regulation of protein metabolic process negative regulation of metabolic process regulation of cellular metabolic process primary metabolic process regulation of molecular function regulation of kinase activity negative regulation of protein phosphorylation macromolecule modification regulation of phosphorus metabolic process metabolic process macromolecule metabolic process regulation of metabolic process regulation of protein modification process regulation of protein phosphorylation negative regulation of phosphate metabolic process organic substance metabolic process protein metabolic process negative regulation of macromolecule metabolic process organonitrogen compound metabolic process negative regulation of molecular function negative regulation of protein kinase activity regulation of protein kinase activity regulation of macromolecule metabolic process negative regulation of phosphorus metabolic process regulation of phosphorylation negative regulation of phosphorylation regulation of MAP kinase activity regulation of protein serine/threonine kinase activity positive regulation of proteasomal protein catabolic process catabolic process positive regulation of protein metabolic process proteolysis involved in protein catabolic process positive regulation of biological process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process regulation of ubiquitin-dependent protein catabolic process positive regulation of metabolic process positive regulation of ubiquitin-dependent protein catabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process modification-dependent macromolecule catabolic process proteolysis positive regulation of macromolecule metabolic process organonitrogen compound catabolic process proteasomal protein catabolic process protein catabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of catabolic process regulation of proteasomal ubiquitin-dependent protein catabolic process modification-dependent protein catabolic process positive regulation of proteolysis regulation of proteasomal protein catabolic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process organic substance catabolic process regulation of protein catabolic process multicellular organismal process negative regulation of interleukin-10 production cellular biosynthetic process interleukin-10 production regulation of cytokine production organic substance biosynthetic process cytokine production regulation of multicellular organismal process regulation of interleukin-10 production regulation of biosynthetic process negative regulation of cytokine production gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process negative regulation of multicellular organismal process	intracellular organelle intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle cellular anatomical entity non-membrane-bounded organelle cytoplasm membrane-bounded organelle nucleus intracellular membrane-bounded organelle
B	Nb4.103 Nanobody	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A	IPR024104	Pseudokinase tribbles family/serine-threonine-protein kinase 40	Family
A	IPR000719	Protein kinase domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q92519	pancreatic intraductal papillary-mucinous carcinoma primitive neuroectodermal tumor ulcerative colitis adenoma Crohn disease glioblastoma large cell medulloblastoma malignant glioma medulloblastoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm psoriasis atopic eczema cystic fibrosis Hashimoto thyroiditis pancreatic intraductal papillary-mucinous carcinoma primitive neuroectodermal tumor ulcerative colitis adenoma Crohn disease glioblastoma large cell medulloblastoma malignant glioma medulloblastoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm psoriasis atopic eczema cystic fibrosis Hashimoto thyroiditis lung cancer malignant mesothelioma oligodendroglioma pancreatic ductal adenocarcinoma pilocytic astrocytoma tuberculosis B-cell chronic lymphocytic leukemia esophageal adenocarcinoma hypothyroidism lymphoplasmacytic lymphoma malignant pancreatic neoplasm osteosarcoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.