Annotations: 7UN3

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth D]	SCOP2B Superfamily	Ubiquitin-like	8066187	3000157	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth D]	PF00240	e7un3D1	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: PF00240	ECOD (1.6)
C [auth B]	PF00956	e7un3B1	A: a+b two layers	X: NAP-like (From Topology)	H: NAP-like (From Topology)	T: NAP-like	F: PF00956	ECOD (1.6)
D [auth C]	PF00956	e7un3C1	A: a+b two layers	X: NAP-like (From Topology)	H: NAP-like (From Topology)	T: NAP-like	F: PF00956	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth D], B [auth A]	PF00240	Ubiquitin family (ubiquitin)	Ubiquitin family	This family contains a number of ubiquitin-like proteins: SUMO (smt3 homologue) (see Swiss:Q02724), Nedd8 (see Swiss:P29595), Elongin B (see Swiss:Q15370), Rub1 (see Swiss:Q9SHE7), and Parkin (see Swiss:O60260). A number of them are thought to carry ...	This family contains a number of ubiquitin-like proteins: SUMO (smt3 homologue) (see Swiss:Q02724), Nedd8 (see Swiss:P29595), Elongin B (see Swiss:Q15370), Rub1 (see Swiss:Q9SHE7), and Parkin (see Swiss:O60260). A number of them are thought to carry a distinctive five-residue motif termed the proteasome-interacting motif (PIM), which may have a biologically significant role in protein delivery to proteasomes and recruitment of proteasomes to transcription sites [5].	Domain
A [auth D], B [auth A]	PF00179	Ubiquitin-conjugating enzyme (UQ_con)	Ubiquitin-conjugating enzyme	Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows conjugation of ubiquitin to a conserved cysteine residue of UBC homologues. TSG101 is one of several UBC homologues that lacks this active site cystein ...	Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows conjugation of ubiquitin to a conserved cysteine residue of UBC homologues. TSG101 is one of several UBC homologues that lacks this active site cysteine [4, 5].	Domain
C [auth B], D [auth C]	PF00956	Nucleosome assembly protein (NAP) (NAP)	Nucleosome assembly protein (NAP)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth D], B [auth A]	Ubiquitin,60S ribosomal protein L8,(E3-independent) E2 ubiquitin-conjugating enzyme fusion	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding ubiquitin conjugating enzyme activity aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein conjugating enzyme activity transferase activity catalytic activity ubiquitin-protein transferase activity RNA binding nucleic acid binding ubiquitin-like protein ligase activity ubiquitin protein ligase activity rRNA binding structural molecule activity structural constituent of ribosome protein tag activity molecular tag activity ubiquitin protein ligase binding protein binding ubiquitin-like protein ligase binding enzyme binding	cellular response to stimulus positive regulation of cell communication cell surface receptor protein serine/threonine kinase signaling pathway regulation of cellular process cellular response to growth factor stimulus positive regulation of signal transduction response to stimulus signaling regulation of transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of biological process regulation of signal transduction positive regulation of BMP signaling pathway cell communication positive regulation of response to stimulus cellular response to endogenous stimulus cellular response to stimulus positive regulation of cell communication cell surface receptor protein serine/threonine kinase signaling pathway regulation of cellular process cellular response to growth factor stimulus positive regulation of signal transduction response to stimulus signaling regulation of transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of biological process regulation of signal transduction positive regulation of BMP signaling pathway cell communication positive regulation of response to stimulus cellular response to endogenous stimulus signal transduction BMP signaling pathway enzyme-linked receptor protein signaling pathway positive regulation of cellular process cellular response to BMP stimulus regulation of biological process regulation of signaling cell surface receptor signaling pathway regulation of BMP signaling pathway response to endogenous stimulus regulation of cellular response to growth factor stimulus biological regulation positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway response to BMP regulation of response to stimulus regulation of cell communication cellular process transforming growth factor beta receptor superfamily signaling pathway response to growth factor positive regulation of signaling organonitrogen compound metabolic process protein polyubiquitination primary metabolic process protein K63-linked ubiquitination organic substance metabolic process protein ubiquitination macromolecule modification metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal cellular localization transport intracellular transport establishment of localization vesicle-mediated transport endosomal transport localization cytosolic transport retrograde transport, endosome to Golgi establishment of localization in cell protein monoubiquitination cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process translation gene expression macromolecule biosynthetic process biosynthetic process organic substance biosynthetic process cytoplasmic translation organonitrogen compound catabolic process catabolic process proteolysis involved in protein catabolic process protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis organic substance catabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear body intracellular organelle nucleoplasm organelle lumen organelle intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen anchoring junction cell junction focal adhesion cell-substrate junction membrane cytosolic ribosome intracellular non-membrane-bounded organelle ribosome non-membrane-bounded organelle postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization synapse asymmetric synapse protein-containing complex ribosomal subunit cytosolic large ribosomal subunit ribonucleoprotein complex large ribosomal subunit vesicle extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle cell periphery plasma membrane organelle subcompartment endomembrane system endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum organelle membrane endoplasmic reticulum membrane intracellular vesicle cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane endocytic vesicle membrane endocytic vesicle vacuolar membrane lytic vacuole vacuole lytic vacuole membrane lysosomal membrane lysosome endosome membrane endosome mitochondrial membrane mitochondrion organelle outer membrane organelle envelope mitochondrial envelope mitochondrial outer membrane outer membrane cytosolic small ribosomal subunit small ribosomal subunit
C [auth B], D [auth C]	Nucleosome assembly protein 1-like 1	protein binding binding histone binding protein-containing complex binding chromatin binding RNA binding organic cyclic compound binding nucleic acid binding protein carrier chaperone histone chaperone activity molecular carrier activity	protein-containing complex organization protein-DNA complex assembly protein-DNA complex organization cellular component organization cellular component biogenesis cellular component assembly chromatin organization protein-containing complex assembly chromatin remodeling cellular process cellular component organization or biogenesis nucleosome assembly nucleosome organization regulation of biological process protein-containing complex organization protein-DNA complex assembly protein-DNA complex organization cellular component organization cellular component biogenesis cellular component assembly chromatin organization protein-containing complex assembly chromatin remodeling cellular process cellular component organization or biogenesis nucleosome assembly nucleosome organization regulation of biological process cell population proliferation regulation of cellular process positive regulation of cell population proliferation regulation of cell population proliferation biological regulation positive regulation of biological process positive regulation of cellular process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process positive regulation of neural precursor cell proliferation neural precursor cell proliferation regulation of neural precursor cell proliferation developmental process multicellular organism development multicellular organismal process anatomical structure development nervous system development system development positive regulation of nervous system development regulation of developmental process cellular developmental process cell development regulation of cell differentiation regulation of neurogenesis regulation of cell development regulation of nervous system development positive regulation of developmental process neurogenesis positive regulation of cell differentiation cell differentiation positive regulation of neurogenesis regulation of multicellular organismal process regulation of multicellular organismal development positive regulation of cell development positive regulation of multicellular organismal process	membrane cellular anatomical entity membrane-bounded organelle intracellular anatomical structure pigment granule intracellular vesicle intracellular membrane-bounded organelle intracellular organelle melanosome cytoplasmic vesicle organelle cytoplasm vesicle protein-containing complex membrane cellular anatomical entity membrane-bounded organelle intracellular anatomical structure pigment granule intracellular vesicle intracellular membrane-bounded organelle intracellular organelle melanosome cytoplasmic vesicle organelle cytoplasm vesicle protein-containing complex protein-DNA complex intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth D], B [auth A]	IPR000608	Ubiquitin-conjugating enzyme E2	Domain
A [auth D], B [auth A]	IPR016135	Ubiquitin-conjugating enzyme/RWD-like	Homologous Superfamily
A [auth D], B [auth A]	IPR022669	Large ribosomal subunit protein uL2, C-terminal	Domain
A [auth D], B [auth A]	IPR014722	Large ribosomal subunit protein uL2, domain 2	Homologous Superfamily
A [auth D], B [auth A]	IPR008991	Translation protein SH3-like domain superfamily	Homologous Superfamily
A [auth D], B [auth A]	IPR023672	Large ribosomal subunit protein uL2, archaeal-type	Family
A [auth D], B [auth A]	IPR022671	Large ribosomal subunit protein uL2, conserved site	Conserved Site
A [auth D], B [auth A]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
A [auth D], B [auth A]	IPR022666	Large ribosomal subunit protein uL2, RNA-binding domain	Domain
A [auth D], B [auth A]	IPR014726	Large ribosomal subunit protein uL2, domain 3	Homologous Superfamily
A [auth D], B [auth A]	IPR002171	Large ribosomal subunit protein uL2	Family
A [auth D], B [auth A]	IPR019954	Ubiquitin conserved site	Conserved Site
A [auth D], B [auth A]	IPR038587	Large ribosomal subunit protein eL40 superfamily	Homologous Superfamily
A [auth D], B [auth A]	IPR000626	Ubiquitin-like domain	Domain
A [auth D], B [auth A]	IPR019956	Ubiquitin domain	Domain
A [auth D], B [auth A]	IPR001975	Large ribosomal subunit protein eL40 domain	Domain
A [auth D], B [auth A]	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily
C [auth B], D [auth C]	IPR002164	Nucleosome assembly protein (NAP)	Family
C [auth B], D [auth C]	IPR037231	NAP-like superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth D], B [auth A]	Pharos: P62987	malignant ependymoma malignant glioma osteosarcoma attention deficit hyperactivity disorder, inattentive type heart disease dental caries lung cancer gastroesophageal reflux disease plasma cell myeloma
C [auth B], D [auth C]	Pharos: P55209	psoriasis amyotrophic lateral sclerosis breast cancer gastric carcinoma lung adenocarcinoma malignant glioma nasopharyngeal carcinoma ovarian cancer ulcerative colitis astrocytic tumor Crohn disease glioblastoma lymphoplasmacytic lymphoma medulloblastoma oligodendroglioma psoriasis amyotrophic lateral sclerosis breast cancer gastric carcinoma lung adenocarcinoma malignant glioma nasopharyngeal carcinoma ovarian cancer ulcerative colitis astrocytic tumor Crohn disease glioblastoma lymphoplasmacytic lymphoma medulloblastoma oligodendroglioma plasma cell myeloma atypical teratoid rhabdoid tumor Emery-Dreifuss muscular dystrophy large cell medulloblastoma malignant ependymoma myopathy osteosarcoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.