7U01

Structure of CD148 fibronectin type III domain 2

External Resource: Annotation

Domain Annotation: ECOD Classification
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e7u01A1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: F_UNCLASSIFIED	ECOD (1.6)
B	F_UNCLASSIFIED	e7u01B1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: F_UNCLASSIFIED	ECOD (1.6)
C	F_UNCLASSIFIED	e7u01C1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: F_UNCLASSIFIED	ECOD (1.6)
D	F_UNCLASSIFIED	e7u01D1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: F_UNCLASSIFIED	ECOD (1.6)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Receptor-type tyrosine-protein phosphatase eta	protein binding binding signaling receptor binding platelet-derived growth factor receptor binding growth factor receptor binding phosphoric ester hydrolase activity hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity catalytic activity delta-catenin binding cell adhesion molecule binding cadherin binding kinase binding protein binding binding signaling receptor binding platelet-derived growth factor receptor binding growth factor receptor binding phosphoric ester hydrolase activity hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity catalytic activity delta-catenin binding cell adhesion molecule binding cadherin binding kinase binding enzyme binding protein kinase binding mitogen-activated protein kinase binding gamma-catenin binding phosphoprotein phosphatase activity catalytic activity, acting on a protein protein tyrosine phosphatase activity beta-catenin binding	regulation of biological process cell adhesion regulation of cellular process regulation of cell adhesion biological regulation cellular process cellular response to stimulus response to organic substance response to stimulus cell surface receptor signaling pathway signaling response to cytokine cytokine-mediated signaling pathway cell communication regulation of biological process cell adhesion regulation of cellular process regulation of cell adhesion biological regulation cellular process cellular response to stimulus response to organic substance response to stimulus cell surface receptor signaling pathway signaling response to cytokine cytokine-mediated signaling pathway cell communication cellular response to chemical stimulus response to chemical cellular response to cytokine stimulus cellular response to organic substance signal transduction negative regulation of signaling negative regulation of biological process regulation of signal transduction regulation of platelet-derived growth factor receptor signaling pathway negative regulation of cell communication cell surface receptor protein tyrosine kinase signaling pathway negative regulation of cellular process enzyme-linked receptor protein signaling pathway regulation of signaling negative regulation of response to stimulus negative regulation of platelet-derived growth factor receptor signaling pathway platelet-derived growth factor receptor signaling pathway negative regulation of signal transduction regulation of response to stimulus regulation of cell communication regulation of catalytic activity negative regulation of catalytic activity regulation of transferase activity regulation of MAP kinase activity intracellular signal transduction negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of kinase activity negative regulation of transferase activity regulation of phosphate metabolic process phosphate-containing compound metabolic process intracellular signaling cassette negative regulation of protein modification process phosphorus metabolic process protein modification process negative regulation of protein metabolic process protein phosphorylation phosphorylation cellular metabolic process regulation of protein metabolic process negative regulation of metabolic process regulation of cellular metabolic process primary metabolic process regulation of MAPK cascade regulation of molecular function regulation of kinase activity negative regulation of protein phosphorylation regulation of protein serine/threonine kinase activity macromolecule modification regulation of phosphorus metabolic process metabolic process macromolecule metabolic process regulation of metabolic process regulation of protein modification process regulation of protein phosphorylation negative regulation of intracellular signal transduction negative regulation of phosphate metabolic process organic substance metabolic process regulation of intracellular signal transduction negative regulation of protein serine/threonine kinase activity protein metabolic process negative regulation of macromolecule metabolic process organonitrogen compound metabolic process negative regulation of molecular function negative regulation of MAP kinase activity regulation of protein kinase activity regulation of macromolecule metabolic process negative regulation of protein kinase activity negative regulation of phosphorus metabolic process MAPK cascade regulation of phosphorylation negative regulation of phosphorylation negative regulation of MAPK cascade regulation of growth regulation of cellular component organization growth negative regulation of cell growth regulation of cell growth cell growth cellular component organization negative regulation of growth cellular component organization or biogenesis positive chemotaxis chemotaxis taxis response to external stimulus locomotion negative regulation of ERBB signaling pathway regulation of epidermal growth factor receptor signaling pathway epidermal growth factor receptor signaling pathway regulation of ERBB signaling pathway negative regulation of epidermal growth factor receptor signaling pathway ERBB signaling pathway regulation of localization import into cell positive regulation of cellular component organization transport positive regulation of biological process vesicle-mediated transport localization positive regulation of endocytosis phagocytosis positive regulation of cellular process regulation of endocytosis regulation of transport regulation of phagocytosis regulation of vesicle-mediated transport establishment of localization positive regulation of phagocytosis positive regulation of transport endocytosis cell-substrate junction assembly positive regulation of cell-substrate junction organization cellular component biogenesis cellular component assembly cell junction assembly positive regulation of cell-substrate adhesion regulation of cell-substrate junction organization focal adhesion assembly positive regulation of focal adhesion assembly positive regulation of cellular component biogenesis regulation of cell-substrate adhesion positive regulation of cell adhesion cell-substrate adhesion positive regulation of cell-matrix adhesion regulation of cellular component biogenesis regulation of cell junction assembly positive regulation of cell junction assembly cell junction organization cell-matrix adhesion regulation of cell-matrix adhesion cell-substrate junction organization regulation of focal adhesion assembly regulation of cell-substrate junction assembly negative regulation of vascular permeability regulation of vascular permeability multicellular organismal process system process circulatory system process vascular process in circulatory system regulation of biological quality blood circulation immune response-regulating cell surface receptor signaling pathway regulation of antigen receptor-mediated signaling pathway negative regulation of antigen receptor-mediated signaling pathway positive regulation of response to stimulus immune response-activating signaling pathway immune response-regulating signaling pathway positive regulation of immune response regulation of immune system process positive regulation of immune system process immune response-activating cell surface receptor signaling pathway immune response regulation of T cell receptor signaling pathway T cell receptor signaling pathway negative regulation of T cell receptor signaling pathway negative regulation of immune system process immune system process regulation of immune response antigen receptor-mediated signaling pathway activation of immune response negative regulation of locomotion regulation of cell motility regulation of locomotion regulation of cell migration negative regulation of cell motility cell migration cell motility negative regulation of cell migration regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of cell communication positive regulation of signal transduction regulation of Fc receptor mediated stimulatory signaling pathway Fc receptor mediated stimulatory signaling pathway positive regulation of Fc receptor mediated stimulatory signaling pathway positive regulation of signaling developmental process cellular developmental process hemopoiesis B cell activation cell activation cell development mononuclear cell differentiation lymphocyte differentiation lymphocyte activation leukocyte activation B cell differentiation cell differentiation anatomical structure development leukocyte differentiation blood vessel morphogenesis tube development angiogenesis vasculature development circulatory system development multicellular organism development anatomical structure morphogenesis tube morphogenesis anatomical structure formation involved in morphogenesis blood vessel development system development positive regulation of intracellular signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of MAPK cascade negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation protein dephosphorylation dephosphorylation peptidyl-tyrosine dephosphorylation regulation of tumor necrosis factor production cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of tumor necrosis factor superfamily cytokine production positive regulation of biosynthetic process cytokine production organic substance biosynthetic process regulation of cytokine production regulation of multicellular organismal process positive regulation of macromolecule metabolic process regulation of biosynthetic process tumor necrosis factor superfamily cytokine production positive regulation of tumor necrosis factor production gene expression macromolecule biosynthetic process tumor necrosis factor production regulation of cellular biosynthetic process regulation of gene expression regulation of tumor necrosis factor superfamily cytokine production biosynthetic process positive regulation of gene expression positive regulation of multicellular organismal process regulation of macromolecule biosynthetic process positive regulation of cytokine production positive regulation of cellular biosynthetic process detection of stimulus contact inhibition detection of cell density detection of biotic stimulus response to biotic stimulus positive regulation of phosphorylation positive regulation of protein metabolic process peptidyl-tyrosine modification positive regulation of phosphate metabolic process positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein modification process peptidyl-amino acid modification positive regulation of protein phosphorylation positive regulation of phosphorus metabolic process regulation of peptidyl-tyrosine phosphorylation peptidyl-tyrosine phosphorylation	membrane-bounded organelle intracellular anatomical structure membrane intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle endomembrane system specific granule membrane intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle organelle membrane-bounded organelle intracellular anatomical structure membrane intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle endomembrane system specific granule membrane intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle organelle membrane secretory granule membrane specific granule cell-cell junction anchoring junction cell junction extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle ruffle cell leading edge plasma membrane leading edge membrane plasma membrane bounded cell projection cell periphery cell projection ruffle membrane plasma membrane region cell projection membrane cell surface immunological synapse

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR016130	Protein-tyrosine phosphatase, active site	Active Site
A, B, C, D	IPR041201	PTPRJ, transmembrane domain	Domain
A, B, C, D	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, B, C, D	IPR003595	Protein-tyrosine phosphatase, catalytic	Domain
A, B, C, D	IPR029021	Protein-tyrosine phosphatase-like	Homologous Superfamily
A, B, C, D	IPR003961	Fibronectin type III	Domain
A, B, C, D	IPR000242	Tyrosine-specific protein phosphatase, PTPase domain	Domain
A, B, C, D	IPR000387	Tyrosine-specific protein phosphatases domain	Domain
A, B, C, D	IPR036116	Fibronectin type III superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: Q12913	childhood acute lymphoblastic leukemia colorectal cancer interstitial cystitis malignant colon neoplasm MALT lymphoma pancreatic intraductal papillary-mucinous carcinoma chronic obstructive pulmonary disease endogenous depression juvenile dermatomyositis malignant ependymoma medulloblastoma pancreatic intraductal papillary-mucinous neoplasm colon carcinoma hypertensive disorder large cell medulloblastoma childhood acute lymphoblastic leukemia colorectal cancer interstitial cystitis malignant colon neoplasm MALT lymphoma pancreatic intraductal papillary-mucinous carcinoma chronic obstructive pulmonary disease endogenous depression juvenile dermatomyositis malignant ependymoma medulloblastoma pancreatic intraductal papillary-mucinous neoplasm colon carcinoma hypertensive disorder large cell medulloblastoma malignant mesothelioma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.