7TN6

Crystal structure of Zea mays Inositol-tetrakisphosphate Kinase 1 mutant (ZmITPK1-H192A)

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF05770	e7tn6A1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: ATP-grasp	F: PF05770	ECOD (1.6)
A	PF17927	e7tn6A2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: PreATP-grasp domain	F: PF17927	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF17927	Inositol 1,3,4-trisphosphate 5/6-kinase pre-ATP-grasp domain (Ins134_P3_kin_N)	Inositol 1,3,4-trisphosphate 5/6-kinase pre-ATP-grasp domain	This family consists of several inositol 1, 3, 4-trisphosphate 5/6-kinase proteins. Inositol 1,3,4-trisphosphate is at a branch point in inositol phosphate metabolism. It is dephosphorylated by specific phosphatases to either inositol 3,4-bisphosphat ...	This family consists of several inositol 1, 3, 4-trisphosphate 5/6-kinase proteins. Inositol 1,3,4-trisphosphate is at a branch point in inositol phosphate metabolism. It is dephosphorylated by specific phosphatases to either inositol 3,4-bisphosphate or inositol 1,3-bisphosphate. Alternatively, it is phosphorylated to inositol 1,3,4,6-tetrakisphosphate or inositol 1,3,4,5-tetrakisphosphate by inositol trisphosphate 5/6-kinase [1]. This entry represents the N-terminal pre-ATP-grasp domain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Inositol-tetrakisphosphate 1-kinase 1	inositol tetrakisphosphate kinase activity kinase activity inositol tetrakisphosphate 1-kinase activity transferase activity inositol phosphate kinase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding inositol tetrakisphosphate kinase activity kinase activity inositol tetrakisphosphate 1-kinase activity transferase activity inositol phosphate kinase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding inositol tetrakisphosphate 6-kinase activity inositol hexakisphosphate 5-kinase activity inositol hexakisphosphate kinase activity phosphotransferase activity, phosphate group as acceptor inositol-1,3,4-trisphosphate 5-kinase activity inositol trisphosphate kinase activity phosphoric ester hydrolase activity inositol phosphate phosphatase activity hydrolase activity, acting on ester bonds inositol tetrakisphosphate phosphatase activity phosphatase activity inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity hydrolase activity inositol-1,3,4-trisphosphate 6-kinase activity	developmental process multicellular organismal process reproductive system development reproductive process developmental process involved in reproduction multicellular organism development fruit development seed development anatomical structure development reproductive structure development post-embryonic development system development polyol metabolic process cellular metabolic process developmental process multicellular organismal process reproductive system development reproductive process developmental process involved in reproduction multicellular organism development fruit development seed development anatomical structure development reproductive structure development post-embryonic development system development polyol metabolic process cellular metabolic process organic hydroxy compound metabolic process alcohol metabolic process inositol phosphate metabolic process organic substance metabolic process organophosphate metabolic process phosphate-containing compound metabolic process inositol trisphosphate metabolic process metabolic process cellular process small molecule metabolic process phosphorus metabolic process small molecule biosynthetic process myo-inositol hexakisphosphate metabolic process biosynthetic process organophosphate biosynthetic process inositol phosphate biosynthetic process organic hydroxy compound biosynthetic process myo-inositol hexakisphosphate biosynthetic process polyol biosynthetic process alcohol biosynthetic process organic substance biosynthetic process phosphorylation	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR041429	Inositol-tetrakisphosphate 1-kinase, N-terminal	Domain
A	IPR008656	Inositol-tetrakisphosphate 1-kinase	Family
A	IPR040464	Inositol 1,3,4-trisphosphate 5/6-kinase, ATP-grasp domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.