7TBU

Crystal structure of the 5-enolpyruvate-shikimate-3-phosphate synthase (EPSPS) domain of Aro1 from Candida albicans in complex with shikimate-3-phosphate

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00275	e7tbuA2	A: a+b two layers	X: IF3-like	H: EPT/RTPC-like (From Topology)	T: EPT/RTPC-like	F: PF00275	ECOD (1.6)
B	PF00275	e7tbuB2	A: a+b two layers	X: IF3-like	H: EPT/RTPC-like (From Topology)	T: EPT/RTPC-like	F: PF00275	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00275	EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) (EPSP_synthase)	EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	5-enolpyruvylshikimate-3-phosphate synthase	kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor shikimate kinase activity transferase activity, transferring phosphorus-containing groups carbon-oxygen lyase activity, acting on phosphates lyase activity carbon-oxygen lyase activity 3-dehydroquinate synthase activity 3-phosphoshikimate 1-carboxyvinyltransferase activity transferase activity, transferring alkyl or aryl (other than methyl) groups binding adenyl ribonucleotide binding kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor shikimate kinase activity transferase activity, transferring phosphorus-containing groups carbon-oxygen lyase activity, acting on phosphates lyase activity carbon-oxygen lyase activity 3-dehydroquinate synthase activity 3-phosphoshikimate 1-carboxyvinyltransferase activity transferase activity, transferring alkyl or aryl (other than methyl) groups binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding hydro-lyase activity 3-dehydroquinate dehydratase activity oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on CH-OH group of donors shikimate 3-dehydrogenase (NADP+) activity cation binding metal ion binding	small molecule biosynthetic process oxoacid metabolic process cellular biosynthetic process cellular metabolic process dicarboxylic acid metabolic process carboxylic acid metabolic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process chorismate metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process chorismate biosynthetic process small molecule biosynthetic process oxoacid metabolic process cellular biosynthetic process cellular metabolic process dicarboxylic acid metabolic process carboxylic acid metabolic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process chorismate metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process chorismate biosynthetic process small molecule metabolic process metabolic process cellular process dicarboxylic acid biosynthetic process amino acid biosynthetic process amino acid metabolic process primary metabolic process organonitrogen compound metabolic process aromatic amino acid family biosynthetic process aromatic amino acid metabolic process organonitrogen compound biosynthetic process organic cyclic compound metabolic process organic cyclic compound biosynthetic process phosphorylation phosphate-containing compound metabolic process phosphorus metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR046346	Aminoacid dehydrogenase-like, N-terminal domain superfamily	Homologous Superfamily
A, B	IPR008289	Pentafunctional AroM protein	Family
A, B	IPR013785	Aldolase-type TIM barrel	Homologous Superfamily
A, B	IPR036968	Enolpyruvate transferase domain superfamily	Homologous Superfamily
A, B	IPR030960	3-dehydroquinate synthase domain	Domain
A, B	IPR013792	RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta	Homologous Superfamily
A, B	IPR001381	3-dehydroquinate dehydratase type I	Family
A, B	IPR031322	Shikimate kinase/gluconokinase	Family
A, B	IPR041121	SDH, C-terminal	Domain
A, B	IPR023193	3-phosphoshikimate 1-carboxyvinyltransferase, conserved site	Conserved Site
A, B	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A, B	IPR001986	Enolpyruvate transferase domain	Domain
A, B	IPR010110	Shikimate dehydrogenase, AroM-type	Domain
A, B	IPR006151	Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase	Domain
A, B	IPR016037	3-dehydroquinate synthase AroB	Domain
A, B	IPR036291	NAD(P)-binding domain superfamily	Homologous Superfamily
A, B	IPR000623	Shikimate kinase/Threonine synthase-like 1	Family
A, B	IPR006264	3-phosphoshikimate 1-carboxyvinyltransferase	Family
A, B	IPR013708	Shikimate dehydrogenase substrate binding, N-terminal	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.