7T92

Structure of the peroxisomal retro-translocon formed by a heterotrimeric ubiquitin ligase complex

External Resource: Annotation

Domain Annotation: ECOD Classification
SAbDab Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
E [auth L]	PF07686	e7t92L1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
D [auth H]	PF07686	e7t92H1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
E [auth L]	Light Chain	IGKV1	Kappa	peroxin-12	SAbDab (2024-05-31)
D [auth H]	Heavy Chain	IGHV3	-	peroxin-12	SAbDab (2024-05-31)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C	PF13923	Zinc finger, C3HC4 type (RING finger) (zf-C3HC4_2)	Zinc finger, C3HC4 type (RING finger)	-	Domain
A [auth B]	PF04757	Pex2 / Pex12 amino terminal region (Pex2_Pex12)	Pex2 / Pex12 amino terminal region	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
C	Peroxin-10	cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding transferase activity catalytic activity	organonitrogen compound metabolic process primary metabolic process organic substance metabolic process protein ubiquitination macromolecule modification metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal protein localization cellular localization organonitrogen compound metabolic process primary metabolic process organic substance metabolic process protein ubiquitination macromolecule modification metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal protein localization cellular localization establishment of protein localization protein localization to peroxisome nitrogen compound transport protein transmembrane import into intracellular organelle transport peroxisomal membrane transport cellular component organization localization peroxisome organization protein transmembrane transport establishment of localization in cell cellular macromolecule localization receptor metabolic process cellular component organization or biogenesis protein import into peroxisome matrix, receptor recycling establishment of protein localization to peroxisome intracellular protein transmembrane transport organic substance transport intracellular transport protein import into peroxisome matrix establishment of localization receptor recycling peroxisomal transport transmembrane transport organelle organization establishment of protein localization to organelle protein transport macromolecule localization protein localization to organelle cellular process intracellular protein transport	membrane-bounded organelle intracellular anatomical structure membrane peroxisome cellular anatomical entity intracellular membrane-bounded organelle microbody membrane intracellular organelle bounding membrane of organelle organelle peroxisomal membrane microbody cytoplasm organelle membrane
E [auth L]	Fab light chain	-	-	-
A [auth B]	Peroxin-12	aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity transferase activity catalytic activity ubiquitin-protein transferase activity cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding	organonitrogen compound metabolic process primary metabolic process protein monoubiquitination organic substance metabolic process protein ubiquitination macromolecule modification metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal protein localization organonitrogen compound metabolic process primary metabolic process protein monoubiquitination organic substance metabolic process protein ubiquitination macromolecule modification metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal protein localization cellular localization establishment of protein localization protein localization to peroxisome nitrogen compound transport protein transmembrane import into intracellular organelle transport peroxisomal membrane transport cellular component organization localization peroxisome organization protein transmembrane transport establishment of localization in cell cellular macromolecule localization receptor metabolic process cellular component organization or biogenesis protein import into peroxisome matrix, receptor recycling establishment of protein localization to peroxisome intracellular protein transmembrane transport organic substance transport intracellular transport protein import into peroxisome matrix establishment of localization receptor recycling peroxisomal transport transmembrane transport organelle organization establishment of protein localization to organelle protein transport macromolecule localization protein localization to organelle cellular process intracellular protein transport	membrane-bounded organelle intracellular anatomical structure membrane peroxisome cellular anatomical entity intracellular membrane-bounded organelle microbody membrane intracellular organelle bounding membrane of organelle organelle peroxisomal membrane microbody cytoplasm organelle membrane membrane-bounded organelle intracellular anatomical structure membrane peroxisome cellular anatomical entity intracellular membrane-bounded organelle microbody membrane intracellular organelle bounding membrane of organelle organelle peroxisomal membrane microbody cytoplasm organelle membrane peroxisomal importomer complex protein-containing complex transporter complex
B [auth A]	Peroxin-2	cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding transferase activity catalytic activity	organonitrogen compound metabolic process primary metabolic process organic substance metabolic process protein ubiquitination macromolecule modification metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal protein localization cellular localization organonitrogen compound metabolic process primary metabolic process organic substance metabolic process protein ubiquitination macromolecule modification metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal protein localization cellular localization establishment of protein localization protein localization to peroxisome nitrogen compound transport protein transmembrane import into intracellular organelle transport peroxisomal membrane transport cellular component organization localization peroxisome organization protein transmembrane transport establishment of localization in cell cellular macromolecule localization receptor metabolic process cellular component organization or biogenesis protein import into peroxisome matrix, receptor recycling establishment of protein localization to peroxisome intracellular protein transmembrane transport organic substance transport intracellular transport protein import into peroxisome matrix establishment of localization receptor recycling peroxisomal transport transmembrane transport organelle organization establishment of protein localization to organelle protein transport macromolecule localization protein localization to organelle cellular process intracellular protein transport	membrane-bounded organelle intracellular anatomical structure membrane peroxisome cellular anatomical entity intracellular membrane-bounded organelle microbody membrane intracellular organelle bounding membrane of organelle organelle peroxisomal membrane microbody cytoplasm organelle membrane
D [auth H]	Fab heavy chain	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C	IPR017907	Zinc finger, RING-type, conserved site	Conserved Site
C	IPR025654	Peroxisome biogenesis factor 2/10	Family
C	IPR006845	Pex, N-terminal	Domain
C	IPR001841	Zinc finger, RING-type	Domain
C	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
A [auth B]	IPR017375	Peroxisome assembly protein 12	Family
A [auth B]	IPR006845	Pex, N-terminal	Domain
B [auth A]	IPR025654	Peroxisome biogenesis factor 2/10	Family
B [auth A]	IPR006845	Pex, N-terminal	Domain

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A [auth B], B [auth A], C	OPM				Peroxisomal protein importer complex

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A [auth B], B [auth A], C	PDBTM	Annotated as membrane protein by PDBTM

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.