Annotations: 7T6G

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00965	Tissue inhibitor of metalloproteinase (TIMP)	Tissue inhibitor of metalloproteinase	Members of this family are common in extracellular regions of vertebrate species	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Truncated Ac-AIP-2	peptidase activity catalytic activity, acting on a protein metallopeptidase activity hydrolase activity catalytic activity protein binding binding enzyme binding protease binding cation binding ion binding metal ion binding small molecule binding enzyme regulator activity peptidase activity catalytic activity, acting on a protein metallopeptidase activity hydrolase activity catalytic activity protein binding binding enzyme binding protease binding cation binding ion binding metal ion binding small molecule binding enzyme regulator activity molecular function inhibitor activity peptidase regulator activity molecular function regulator activity enzyme inhibitor activity peptidase inhibitor activity endopeptidase regulator activity metalloendopeptidase inhibitor activity endopeptidase inhibitor activity	negative regulation of membrane protein ectodomain proteolysis negative regulation of cellular catabolic process catabolic process regulation of cellular process negative regulation of proteolysis negative regulation of biological process macromolecule catabolic process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of protein catabolic process cellular catabolic process organic substance metabolic process regulation of proteolysis proteolysis membrane protein proteolysis negative regulation of membrane protein ectodomain proteolysis negative regulation of cellular catabolic process catabolic process regulation of cellular process negative regulation of proteolysis negative regulation of biological process macromolecule catabolic process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of protein catabolic process cellular catabolic process organic substance metabolic process regulation of proteolysis proteolysis membrane protein proteolysis negative regulation of cellular process protein metabolic process negative regulation of protein metabolic process membrane protein ectodomain proteolysis negative regulation of macromolecule metabolic process organonitrogen compound catabolic process negative regulation of catabolic process regulation of membrane protein ectodomain proteolysis regulation of biological process organonitrogen compound metabolic process cellular metabolic process regulation of protein metabolic process negative regulation of metabolic process biological regulation primary metabolic process regulation of cellular metabolic process regulation of catabolic process regulation of macromolecule metabolic process protein catabolic process regulation of cellular catabolic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process organic substance catabolic process regulation of protein catabolic process response to organic substance response to stimulus response to chemical	cell periphery extracellular matrix external encapsulating structure cellular anatomical entity extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001134	Netrin domain	Domain
A	IPR008993	Tissue inhibitor of metalloproteinases-like, OB-fold	Homologous Superfamily
A	IPR001820	Protease inhibitor I35 (TIMP)	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.