7SAY

Fragment of streptococcal M87 protein fused to GCN4 adaptor in complex with human cathelicidin

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Leucine zipper-like	8037025	3001609	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Leucine zipper-like	8037025	3001609	SCOP2B (2022-06-29)
E [auth D]	SCOP2B Superfamily	Leucine zipper-like	8037025	3001609	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e7sayA1	A: a+b duplicates or obligate multimers	X: MPER trimer (From Topology)	H: MPER trimer (From Topology)	T: MPER trimer	F: F_UNCLASSIFIED	ECOD (1.6)
D [auth C]	F_UNCLASSIFIED	e7sayC1	A: a+b duplicates or obligate multimers	X: MPER trimer (From Topology)	H: MPER trimer (From Topology)	T: MPER trimer	F: F_UNCLASSIFIED	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, D [auth C], E [auth D]	PF07716	Basic region leucine zipper (bZIP_2)	Basic region leucine zipper	-	Coiled-coil
C [auth E], F	PF12153	LPS binding domain of CAP18 (C terminal) (CAP18_C)	LPS binding domain of CAP18 (C terminal)	This domain family is found in eukaryotes, and is approximately 30 amino acids in length, and the family is found in association with Pfam:PF00666. CAP18 is a protein which is derived from rabbit granulocytes. It has two domains, an N terminal DUF an ...	This domain family is found in eukaryotes, and is approximately 30 amino acids in length, and the family is found in association with Pfam:PF00666. CAP18 is a protein which is derived from rabbit granulocytes. It has two domains, an N terminal DUF and a C terminal Gram negative LPS binding domain. This domain is the C terminal domain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, D [auth C], E [auth D]	General control transcription factor GCN4/M protein chimera	TFIID-class transcription factor complex binding transcription factor binding basal transcription machinery binding protein-containing complex binding protein binding binding basal RNA polymerase II transcription machinery binding general transcription initiation factor binding RNA polymerase II general transcription initiation factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding DNA binding sequence-specific DNA binding double-stranded DNA binding TFIID-class transcription factor complex binding transcription factor binding basal transcription machinery binding protein-containing complex binding protein binding binding basal RNA polymerase II transcription machinery binding general transcription initiation factor binding RNA polymerase II general transcription initiation factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding DNA binding sequence-specific DNA binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding organic cyclic compound binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding chromatin binding transcription regulator activity DNA-binding transcription factor activity mediator complex binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity identical protein binding	response to nutrient levels response to stimulus response to stress response to amino acid starvation response to starvation positive regulation of cellular response to amino acid starvation cellular response to stimulus regulation of response to nutrient levels regulation of cellular process positive regulation of biological process regulation of cellular response to stress cellular response to amino acid starvation positive regulation of response to stimulus cellular response to stress response to nutrient levels response to stimulus response to stress response to amino acid starvation response to starvation positive regulation of cellular response to amino acid starvation cellular response to stimulus regulation of response to nutrient levels regulation of cellular process positive regulation of biological process regulation of cellular response to stress cellular response to amino acid starvation positive regulation of response to stimulus cellular response to stress regulation of response to stress positive regulation of cellular process regulation of biological process biological regulation cellular response to starvation cellular response to nutrient levels regulation of response to stimulus cellular process regulation of cellular response to amino acid starvation positive regulation of response to nutrient levels transcription preinitiation complex assembly positive regulation of macromolecule biosynthetic process regulation of primary metabolic process cellular component biogenesis nucleobase-containing compound metabolic process DNA-templated transcription positive regulation of metabolic process regulation of DNA-templated transcription initiation regulation of RNA metabolic process cellular component assembly transcription by RNA polymerase II organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process transcription initiation at RNA polymerase II promoter regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process cellular metabolic process primary metabolic process regulation of cellular metabolic process positive regulation of transcription by RNA polymerase II positive regulation of DNA-templated transcription initiation positive regulation of RNA metabolic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process RNA polymerase II preinitiation complex assembly metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process regulation of RNA polymerase II transcription preinitiation complex assembly regulation of cellular component organization positive regulation of cellular component organization cellular biosynthetic process positive regulation of DNA-templated transcription RNA metabolic process positive regulation of cellular metabolic process cellular component organization protein-DNA complex organization RNA biosynthetic process nucleic acid biosynthetic process regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly organic substance metabolic process positive regulation of biosynthetic process protein-containing complex assembly cellular component organization or biogenesis regulation of RNA biosynthetic process regulation of biosynthetic process positive regulation of RNA polymerase II transcription preinitiation complex assembly protein-containing complex organization positive regulation of cellular component biogenesis positive regulation of transcription initiation by RNA polymerase II protein-DNA complex assembly regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression regulation of cellular component biogenesis macromolecule biosynthetic process DNA-templated transcription initiation nucleic acid metabolic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process regulation of transcription initiation by RNA polymerase II positive regulation of cellular biosynthetic process protein localization localization cellular localization protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to nuclear periphery protein localization to nucleus amino acid biosynthetic process amino acid metabolic process cellular response to nitrogen compound response to organic substance nitrogen catabolite regulation of transcription regulation of nitrogen utilization intracellular nitrogen homeostasis nitrogen catabolite activation of transcription from RNA polymerase II promoter response to organonitrogen compound response to nitrogen compound cellular response to organonitrogen compound chemical homeostasis response to chemical homeostatic process cellular response to endogenous stimulus nitrogen catabolite activation of transcription intracellular chemical homeostasis cellular response to organic substance nitrogen catabolite regulation of transcription from RNA polymerase II promoter response to endogenous stimulus response to nutrient nitrogen utilization cellular response to chemical stimulus cellular homeostasis cellular response to nutrient signaling signal transduction intracellular signal transduction cell communication negative regulation of biological process negative regulation of cellular metabolic process negative regulation of RNA biosynthetic process negative regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process negative regulation of cellular process negative regulation of macromolecule metabolic process negative regulation of biosynthetic process regulation of ribosomal protein gene transcription by RNA polymerase II negative regulation of ribosomal protein gene transcription by RNA polymerase II	RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle organelle
C [auth E], F	Antibacterial peptide LL-37	binding lipid binding lipopolysaccharide binding carbohydrate derivative binding	cellular response to stimulus cellular response to nitrogen compound response to organic substance biological process involved in interspecies interaction between organisms response to stimulus response to biotic stimulus cellular response to biotic stimulus cellular response to endogenous stimulus response to bacterium response to external biotic stimulus cellular response to organic substance response to peptidoglycan response to other organism response to organonitrogen compound cellular response to stimulus cellular response to nitrogen compound response to organic substance biological process involved in interspecies interaction between organisms response to stimulus response to biotic stimulus cellular response to biotic stimulus cellular response to endogenous stimulus response to bacterium response to external biotic stimulus cellular response to organic substance response to peptidoglycan response to other organism response to organonitrogen compound response to endogenous stimulus cellular response to peptidoglycan response to oxygen-containing compound response to external stimulus response to nitrogen compound cellular response to molecule of bacterial origin cellular response to oxygen-containing compound cellular response to chemical stimulus cellular response to organonitrogen compound response to chemical cellular process response to molecule of bacterial origin organonitrogen compound metabolic process primary metabolic process amyloid fibril formation cellular component organization organic substance metabolic process metabolic process protein metabolic process macromolecule metabolic process cellular component organization or biogenesis supramolecular fiber organization neutrophil activation multicellular organismal process immune system process cell activation myeloid leukocyte activation granulocyte activation leukocyte activation humoral immune response defense response immune response antibacterial humoral response defense response to symbiont antimicrobial humoral response defense response to bacterium defense response to other organism response to stress innate immune response response to lipid cellular response to lipopolysaccharide response to lipopolysaccharide cellular response to lipid regulation of biological process cell population proliferation regulation of cellular process positive regulation of cell population proliferation regulation of cell population proliferation biological regulation positive regulation of biological process positive regulation of cellular process response to cytokine cellular response to tumor necrosis factor cellular response to cytokine stimulus response to tumor necrosis factor response to interleukin-6 cellular response to interleukin-6 disruption of cell in another organism biological process involved in symbiotic interaction killing by host of symbiont cells disruption of anatomical structure in another organism biological process involved in interaction with symbiont killing of cells of another organism cell killing innate immune response in mucosa mucosal immune response organ or tissue specific immune response regulation of developmental process angiogenesis regulation of vasculature development positive regulation of developmental process multicellular organism development tube morphogenesis anatomical structure development regulation of multicellular organismal process regulation of anatomical structure morphogenesis blood vessel development system development developmental process regulation of multicellular organismal development blood vessel morphogenesis tube development positive regulation of angiogenesis vasculature development circulatory system development anatomical structure morphogenesis positive regulation of vasculature development regulation of angiogenesis anatomical structure formation involved in morphogenesis positive regulation of multicellular organismal process antimicrobial humoral immune response mediated by antimicrobial peptide cytolysis defense response to Gram-negative bacterium positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of cellular metabolic process positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of metabolic process positive regulation of protein modification process regulation of phosphate metabolic process phosphate-containing compound metabolic process positive regulation of macromolecule metabolic process positive regulation of protein phosphorylation phosphorus metabolic process protein modification process protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation cellular metabolic process regulation of protein metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process macromolecule modification regulation of phosphorus metabolic process regulation of phosphorylation regulation of metabolic process cellular response to interleukin-1 response to interleukin-1 defense response to Gram-positive bacterium	extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle intracellular anatomical structure tertiary granule lumen membrane-enclosed lumen intracellular vesicle extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle intracellular anatomical structure tertiary granule lumen membrane-enclosed lumen intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen tertiary granule intracellular organelle organelle lumen cytoplasmic vesicle secretory granule secretory vesicle cytoplasm vesicle lumen cytoplasmic vesicle lumen secretory granule lumen specific granule lumen specific granule cell projection

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, D [auth C], E [auth D]	IPR004827	Basic-leucine zipper domain	Domain
A, B, D [auth C], E [auth D]	IPR046347	Basic-leucine zipper domain superfamily	Homologous Superfamily
A, B, D [auth C], E [auth D]	IPR003345	M protein repeat	Repeat
C [auth E], F	IPR046350	Cystatin superfamily	Homologous Superfamily
C [auth E], F	IPR001894	Cathelicidin-like	Family
C [auth E], F	IPR022746	Cathelicidin, antimicrobial peptide, C-terminal	Domain
C [auth E], F	IPR018216	Cathelicidin, conserved site	Conserved Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
C [auth E], F	Pharos: P49913	psoriasis breast cancer lung adenocarcinoma chronic obstructive pulmonary disease lymphoplasmacytic lymphoma rosacea heart disease osteosarcoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.