Annotations: 7R9G

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01416	tRNA pseudouridine synthase (PseudoU_synth_1)	tRNA pseudouridine synthase	Involved in the formation of pseudouridine at the anticodon stem and loop of transfer-RNAs Pseudouridine is an isomer of uridine (5-(beta-D-ribofuranosyl) uracil, and id the most abundant modified nucleoside found in all cellular RNAs. The TruA-like ...	Involved in the formation of pseudouridine at the anticodon stem and loop of transfer-RNAs Pseudouridine is an isomer of uridine (5-(beta-D-ribofuranosyl) uracil, and id the most abundant modified nucleoside found in all cellular RNAs. The TruA-like proteins also exhibit a conserved sequence with a strictly conserved aspartic acid, likely involved in catalysis.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	tRNA pseudouridine synthase 1	RNA binding binding organic cyclic compound binding nucleic acid binding mRNA binding isomerase activity pseudouridine synthase activity catalytic activity intramolecular transferase activity	cellular biosynthetic process cellular metabolic process tRNA modification RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process RNA modification organic substance metabolic process biosynthetic process tRNA processing cellular biosynthetic process cellular metabolic process tRNA modification RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process RNA modification organic substance metabolic process biosynthetic process tRNA processing macromolecule modification organic substance biosynthetic process nucleic acid catabolic process metabolic process cellular process macromolecule metabolic process RNA processing pseudouridine synthesis snRNA modification snRNA pseudouridine synthesis snRNA metabolic process mRNA modification mRNA metabolic process mRNA pseudouridine synthesis mRNA processing tRNA pseudouridine synthesis	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen
B	RNA (5'-R(APAPAPUPCPGPGPGPAPUPUPCPCPGPGPAPUPA)-3')	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR020103	Pseudouridine synthase, catalytic domain superfamily	Homologous Superfamily
A	IPR041708	Pseudouridine synthase PUS1/ PUS2-like	Family
A	IPR020094	Pseudouridine synthase TruA/RsuA/RluB/E/F, N-terminal	Homologous Superfamily
A	IPR001406	Pseudouridine synthase I, TruA	Family
A	IPR020097	Pseudouridine synthase I, TruA, alpha/beta domain	Domain
A	IPR020095	Pseudouridine synthase I, TruA, C-terminal	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.