7QWR

Structure of the ribosome-nascent chain containing an ER signal sequence in complex with NAC

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
F [auth B]	SCOP2B Superfamily	Translational proteins	8078357	3000811	SCOP2B (2022-06-29)
K [auth e]	SCOP2B Superfamily	Ribosomal protein L32e	8102088	3000982	SCOP2B (2022-06-29)
O [auth g]	SCOP2B Superfamily	Ribosomal protein L34e-like	8053543	3002203	SCOP2B (2022-06-29)
T [auth I]	SCOP2B Superfamily	Ribosomal protein L16p/L10e	8097320	3000884	SCOP2B (2022-06-29)
NA [auth V]	SCOP2B Superfamily	50S Ribosomal protein L14-like	8072048	3000433	SCOP2B (2022-06-29)
QA [auth X]	SCOP2B Superfamily	Ribosomal proteins S24e L23 and L15e	8095966	3000210	SCOP2B (2022-06-29)
VA [auth a]	SCOP2B Superfamily	Ribosomal proteins L15p and L18e	8097818	3001045	SCOP2B (2022-06-29)
J [auth D]	SCOP2B Superfamily	Translational machinery components	8052886	3000571	SCOP2B (2022-06-29)
M [auth f]	SCOP2B Superfamily	Translational proteins	8093714	3000811	SCOP2B (2022-06-29)
S [auth i]	SCOP2B Superfamily	Ribosomal protein L36e	8053119	3002161	SCOP2B (2022-06-29)
V [auth J]	SCOP2B Superfamily	RL5-like	8073894	3001709	SCOP2B (2022-06-29)
Y [auth l]	SCOP2B Superfamily	Ribosomal protein L39e	8095595	3001756	SCOP2B (2022-06-29)
BA [auth N]	SCOP2B Superfamily	Ribosomal proteins S24e L23 and L15e	8082477	3000210	SCOP2B (2022-06-29)
GA [auth p]	SCOP2B Superfamily	Zn-binding ribosomal proteins	8101435	3001320	SCOP2B (2022-06-29)
HA [auth Q]	SCOP2B Superfamily	Ribosomal proteins L15p and L18e	8095982	3001045	SCOP2B (2022-06-29)
SA [auth Y]	SCOP2B Superfamily	Translation proteins SH3-like KOW motif containing domain	8076754	3000334	SCOP2B (2022-06-29)
UA [auth Z]	SCOP2B Superfamily	Translation proteins SH3-like KOW motif containing domain	8053047	3000334	SCOP2B (2022-06-29)
E [auth b]	SCOP2B Superfamily	Ribosomal protein L29e	8053037	3002157	SCOP2B (2022-06-29)
G [auth c]	SCOP2B Superfamily	L30e-like	8094953	3001739	SCOP2B (2022-06-29)
H [auth C]	SCOP2B Superfamily	Ribosomal protein L4	8052829	3001146	SCOP2B (2022-06-29)
H [auth C]	SCOP2B Superfamily	60S ribosomal protein L4 C-terminal domain-like	8052828	3002143	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
F [auth B]	PF00297	e7qwrB1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF00297	ECOD (1.6)
K [auth e]	PF01655	e7qwre1	A: a/b three-layered sandwiches	X: Ribosomal protein L13/L15p/L18e/L32e	H: Ribosomal protein L32e (From Topology)	T: Ribosomal protein L32e	F: PF01655	ECOD (1.6)
L [auth E]	PF01159,PF03868	e7qwrE1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01159,PF03868	ECOD (1.6)
O [auth g]	PF01199	e7qwrg1	A: few secondary structure elements	X: Glucocorticoid receptor-like	H: RPL34 (From Topology)	T: RPL34	F: PF01199	ECOD (1.6)
Q [auth h]	PF00831	e7qwrh1	A: alpha bundles	X: Long alpha-hairpin	H: Ribosomal protein L29 (L29p) (From Topology)	T: Ribosomal protein L29 (L29p)	F: PF00831	ECOD (1.6)
T [auth I]	PF00252	e7qwrI1	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: Ribosomal protein L10e	F: PF00252	ECOD (1.6)
U [auth j]	PF01907	e7qwrj1	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: PF01907	ECOD (1.6)
DA [auth O]	PF00572	e7qwrO1	A: a/b three-layered sandwiches	X: Ribosomal protein L13/L15p/L18e/L32e	H: Ribosomal protein L13 and L16-A (From Topology)	T: Ribosomal protein L13 and L16-A	F: PF00572	ECOD (1.6)
NA [auth V]	PF00238	e7qwrV1	A: beta barrels	X: Ribosomal protein L14-like	H: Ribosomal protein L14-related (From Topology)	T: Ribosomal protein L14-related	F: PF00238	ECOD (1.6)
OA [auth W]	PF01246	e7qwrW1	A: few secondary structure elements	X: Glucocorticoid receptor-like	H: LIM domain-like	T: LIM domain-like	F: PF01246	ECOD (1.6)
QA [auth X]	PF00276,PF03939	e7qwrX1	A: a+b two layers	X: Alpha-beta plaits	H: Ribosomal proteins S24e, L23 and L15e (From Topology)	T: Ribosomal proteins S24e, L23 and L15e	F: PF00276,PF03939	ECOD (1.6)
VA [auth a]	PF00828	e7qwra1	A: a/b three-layered sandwiches	X: Ribosomal protein L13/L15p/L18e/L32e	H: Ribosomal proteins L15p and L18e (From Topology)	T: Ribosomal proteins L15p and L18e	F: PF00828	ECOD (1.6)
J [auth D]	PF14204,PF17144	e7qwrD1	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: PF14204,PF17144	ECOD (1.6)
M [auth f]	PF01247	e7qwrf1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF01247	ECOD (1.6)
N [auth F]	PF00327,PF08079	e7qwrF1	A: a+b two layers	X: Ribosomal protein L30p/L7e (From Topology)	H: Ribosomal protein L30p/L7e (From Topology)	T: Ribosomal protein L30p/L7e	F: PF00327,PF08079	ECOD (1.6)
P [auth G]	PF01248	e7qwrG1	A: a+b three layers	X: Bacillus chorismate mutase-like	H: L30e-like (From Topology)	T: L30e-like	F: PF01248	ECOD (1.6)
R [auth H]	PF00347	e7qwrH1	A: a+b two layers	X: Ribosomal protein L6 (From Topology)	H: Ribosomal protein L6 (From Topology)	T: Ribosomal protein L6	F: PF00347	ECOD (1.6)
S [auth i]	PF01158	e7qwri1	A: alpha arrays	X: 60S ribosomal protein rpL36 (L36e) (From Topology)	H: 60S ribosomal protein rpL36 (L36e) (From Topology)	T: 60S ribosomal protein rpL36 (L36e)	F: PF01158	ECOD (1.6)
B [auth t]	PF01849	e7qwrt1	A: beta sandwiches	X: Nascent polypeptide-associated complex (NAC) dimerization domain (From Topology)	H: Nascent polypeptide-associated complex (NAC) dimerization domain (From Topology)	T: Nascent polypeptide-associated complex (NAC) dimerization domain	F: PF01849	ECOD (1.6)
V [auth J]	PF00281,PF00673	e7qwrJ1	A: a+b two layers	X: Ribosomal protein L5 (From Topology)	H: Ribosomal protein L5 (From Topology)	T: Ribosomal protein L5	F: PF00281,PF00673	ECOD (1.6)
W [auth k]	PF01781	e7qwrk1	A: a+b two layers	X: SRP9/14-like	H: Signal recognition particle alu RNA binding heterodimer SRP9/14-related (From Topology)	T: Signal recognition particle alu RNA binding heterodimer SRP9/14-related	F: PF01781	ECOD (1.6)
X [auth L]	PF01294	e7qwrL1	A: extended segments	X: RPL13 (From Topology)	H: RPL13 (From Topology)	T: RPL13	F: PF01294	ECOD (1.6)
Y [auth l]	PF00832	e7qwrl1	A: extended segments	X: Ribosomal protein L39e (From Topology)	H: Ribosomal protein L39e (From Topology)	T: Ribosomal protein L39e	F: PF00832	ECOD (1.6)
Z [auth M]	PF00467,PF01929	e7qwrM1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF00467,PF01929	ECOD (1.6)
AA [auth m]	PF01020	e7qwrm1	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: PF01020	ECOD (1.6)
BA [auth N]	PF00827	e7qwrN1	A: a+b two layers	X: Alpha-beta plaits	H: Ribosomal proteins S24e, L23 and L15e (From Topology)	T: Ribosomal proteins S24e, L23 and L15e	F: PF00827	ECOD (1.6)
CA [auth n]	PF05162	e7qwrn1	A: extended segments	X: Ribosomal protein L41-A (From Topology)	H: Ribosomal protein L41-A (From Topology)	T: Ribosomal protein L41-A	F: PF05162	ECOD (1.6)
EA [auth o]	PF00935	e7qwro1	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: PF00935	ECOD (1.6)
FA [auth P]	PF00237	e7qwrP1	A: a+b two layers	X: Enolase-N/ribosomal protein	H: Ribosomal protein L22 (From Topology)	T: Ribosomal protein L22	F: PF00237	ECOD (1.6)
GA [auth p]	PF01780	e7qwrp1	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: PF01780	ECOD (1.6)
HA [auth Q]	PF17135	e7qwrQ1	A: a/b three-layered sandwiches	X: Ribosomal protein L13/L15p/L18e/L32e	H: Ribosomal proteins L15p and L18e (From Topology)	T: Ribosomal proteins L15p and L18e	F: PF17135	ECOD (1.6)
IA [auth r]	PF01778	e7qwrr1	A: a+b two layers	X: RPL28 (From Topology)	H: RPL28 (From Topology)	T: RPL28	F: PF01778	ECOD (1.6)
JA [auth R]	PF01280	e7qwrR2	A: alpha arrays	X: Ribosomal protein L19 (L19e) N-terminal domain (From Topology)	H: Ribosomal protein L19 (L19e) N-terminal domain (From Topology)	T: Ribosomal protein L19 (L19e) N-terminal domain	F: PF01280	ECOD (1.6)
JA [auth R]	PF01280	e7qwrR1	A: alpha bundles	X: Ribosomal protein L19 (L19e) C-terminal domain (From Topology)	H: Ribosomal protein L19 (L19e) C-terminal domain (From Topology)	T: Ribosomal protein L19 (L19e) C-terminal domain	F: PF01280	ECOD (1.6)
KA [auth S]	F_UNCLASSIFIED	e7qwrS1	A: a+b two layers	X: GP2-like	H: RplX-like (From Topology)	T: RplX-like	F: F_UNCLASSIFIED	ECOD (1.6)
KA [auth S]	PF01775	e7qwrS2	A: a+b two layers	X: GP2-like	H: RplX-like (From Topology)	T: RplX-like	F: PF01775	ECOD (1.6)
LA [auth T]	PF01157	e7qwrT1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01157	ECOD (1.6)
MA [auth U]	PF01776	e7qwrU1	A: a+b two layers	X: Ribosomal protein L22e (From Topology)	H: Ribosomal protein L22e (From Topology)	T: Ribosomal protein L22e	F: PF01776	ECOD (1.6)
D [auth A]	PF00181	e7qwrA1	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF00181	ECOD (1.6)
D [auth A]	PF03947	e7qwrA2	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF03947	ECOD (1.6)
SA [auth Y]	PF16906	e7qwrY1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF16906	ECOD (1.6)
UA [auth Z]	PF00467,PF01777	e7qwrZ1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF00467,PF01777	ECOD (1.6)
E [auth b]	PF01779	e7qwrb1	A: extended segments	X: RPL29 (From Topology)	H: RPL29 (From Topology)	T: RPL29	F: PF01779	ECOD (1.6)
G [auth c]	PF01248	e7qwrc1	A: a+b three layers	X: Bacillus chorismate mutase-like	H: L30e-like (From Topology)	T: L30e-like	F: PF01248	ECOD (1.6)
H [auth C]	PF00573	e7qwrC1	A: a/b three-layered sandwiches	X: Ribosomal protein L4 (From Topology)	H: Ribosomal protein L4 (From Topology)	T: Ribosomal protein L4	F: PF00573	ECOD (1.6)
H [auth C]	PF14374	e7qwrC2	A: extended segments	X: C-terminal helical region in 60S ribosomal protein L4 (L4p) (From Topology)	H: C-terminal helical region in 60S ribosomal protein L4 (L4p) (From Topology)	T: C-terminal helical region in 60S ribosomal protein L4 (L4p)	F: PF14374	ECOD (1.6)
I [auth d]	PF01198	e7qwrd1	A: a+b two layers	X: Ribosomal protein L31e-like	H: Ribosomal protein L31e/gp120 outer domain (From Topology)	T: Ribosomal protein L31e/gp120 outer domain	F: PF01198	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
F [auth B]	PF00297	Ribosomal protein L3 (Ribosomal_L3)	Ribosomal protein L3	-	Family
K [auth e]	PF01655	Ribosomal protein L32 (Ribosomal_L32e)	Ribosomal protein L32	-	Family
L [auth E]	PF03868	Ribosomal protein L6, N-terminal domain (Ribosomal_L6e_N)	Ribosomal protein L6, N-terminal domain	-	Domain
L [auth E]	PF01159	Ribosomal protein L6e (Ribosomal_L6e)	Ribosomal protein L6e	-	Family
O [auth g]	PF01199	Ribosomal protein L34e (Ribosomal_L34e)	Ribosomal protein L34e	-	Family
Q [auth h]	PF00831	Ribosomal L29 protein (Ribosomal_L29)	Ribosomal L29 protein	-	Family
T [auth I]	PF00252	Ribosomal protein L16p/L10e (Ribosomal_L16)	Ribosomal protein L16p/L10e	-	Domain
U [auth j]	PF01907	Ribosomal protein L37e (Ribosomal_L37e)	Ribosomal protein L37e	-	Family
NA [auth V]	PF00238	Ribosomal protein L14p/L23e (Ribosomal_L14)	Ribosomal protein L14p/L23e	-	Domain
OA [auth W]	PF01246	Ribosomal protein L24e (Ribosomal_L24e)	Ribosomal protein L24e	-	Domain
QA [auth X]	PF03939	Ribosomal protein L23, N-terminal domain (Ribosomal_L23eN)	Ribosomal protein L23, N-terminal domain	-	Family
QA [auth X]	PF00276	Ribosomal protein L23 (Ribosomal_L23)	Ribosomal protein L23	-	Family
VA [auth a]	PF00828	Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A (Ribosomal_L27A)	Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A	-	Family
J [auth D]	PF17144	Ribosomal large subunit proteins 60S L5, and 50S L18 (Ribosomal_L5e)	Ribosomal large subunit proteins 60S L5, and 50S L18	-	Family
J [auth D]	PF14204	Ribosomal L18 C-terminal region (Ribosomal_L18_c)	Ribosomal L18 C-terminal region	This domain is the C-terminal end of ribosomal L18/L5 proteins.	Domain
M [auth f]	PF01247	Ribosomal protein L35Ae (Ribosomal_L35Ae)	Ribosomal protein L35Ae	-	Domain
N [auth F]	PF08079	Ribosomal L30 N-terminal domain (Ribosomal_L30_N)	Ribosomal L30 N-terminal domain	This presumed domain is found at the N-terminus of Ribosomal L30 proteins and has been termed RL30NT or NUC018 [1].	Domain
N [auth F]	PF00327	Ribosomal protein L30p/L7e (Ribosomal_L30)	Ribosomal protein L30p/L7e	This family includes prokaryotic L30 and eukaryotic L7.	Domain
P [auth G]	PF01248	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family (Ribosomal_L7Ae)	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family	This family includes: Ribosomal L7A from metazoa, Ribosomal L8-A and L8-B from fungi, 30S ribosomal protein HS6 from archaebacteria, 40S ribosomal protein S12 from eukaryotes, Ribosomal protein L30 from eukaryotes and archaebacteria. Gadd45 and MyD11 ...	This family includes: Ribosomal L7A from metazoa, Ribosomal L8-A and L8-B from fungi, 30S ribosomal protein HS6 from archaebacteria, 40S ribosomal protein S12 from eukaryotes, Ribosomal protein L30 from eukaryotes and archaebacteria. Gadd45 and MyD118 [1].	Domain
R [auth H]	PF00347	Ribosomal protein L6 (Ribosomal_L6)	Ribosomal protein L6	-	Domain
S [auth i]	PF01158	Ribosomal protein L36e (Ribosomal_L36e)	Ribosomal protein L36e	-	Family
B [auth t]	PF01849	NAC domain (NAC)	NAC domain	-	Family
V [auth J]	PF00281	Ribosomal protein L5 (Ribosomal_L5)	Ribosomal protein L5	-	Domain
V [auth J]	PF00673	ribosomal L5P family C-terminus (Ribosomal_L5_C)	ribosomal L5P family C-terminus	This region is found associated with Pfam:PF00281.	Domain
X [auth L]	PF01294	Ribosomal protein L13e (Ribosomal_L13e)	Ribosomal protein L13e	-	Family
Y [auth l]	PF00832	Ribosomal L39 protein (Ribosomal_L39)	Ribosomal L39 protein	-	Family
Z [auth M]	PF01929	Ribosomal protein L14 (Ribosomal_L14e)	Ribosomal protein L14	-	Family
BA [auth N]	PF00827	Ribosomal L15 (Ribosomal_L15e)	Ribosomal L15	-	Family
CA [auth n]	PF05162	Ribosomal protein L41 (Ribosomal_L41)	Ribosomal protein L41	-	Family
C [auth u]	PF01849	NAC domain (NAC)	NAC domain	-	Family
EA [auth o]	PF00935	Ribosomal protein L44 (Ribosomal_L44)	Ribosomal protein L44	-	Family
GA [auth p]	PF01780	Ribosomal L37ae protein family (Ribosomal_L37ae)	Ribosomal L37ae protein family	-	Family
HA [auth Q]	PF17135	Ribosomal protein 60S L18 and 50S L18e (Ribosomal_L18)	Ribosomal protein 60S L18 and 50S L18e	-	Family
IA [auth r]	PF01778	Ribosomal L28e protein family (Ribosomal_L28e)	Ribosomal L28e protein family	-	Family
JA [auth R]	PF01280	Ribosomal protein L19e (Ribosomal_L19e)	Ribosomal protein L19e	-	Family
LA [auth T]	PF01157	Ribosomal protein L21e (Ribosomal_L21e)	Ribosomal protein L21e	-	Family
D [auth A]	PF03947	Ribosomal Proteins L2, C-terminal domain (Ribosomal_L2_C)	Ribosomal Proteins L2, C-terminal domain	-	Domain
SA [auth Y]	PF16906	Ribosomal proteins L26 eukaryotic, L24P archaeal (Ribosomal_L26)	Ribosomal proteins L26 eukaryotic, L24P archaeal	-	Family
SA [auth Y]	PF00467	KOW motif (KOW)	KOW motif	-	Family
UA [auth Z]	PF01777	Ribosomal L27e protein family (Ribosomal_L27e)	Ribosomal L27e protein family	-	Family
UA [auth Z]	PF00467	KOW motif (KOW)	KOW motif	-	Family
E [auth b]	PF01779	Ribosomal L29e protein family (Ribosomal_L29e)	Ribosomal L29e protein family	-	Family
G [auth c]	PF01248	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family (Ribosomal_L7Ae)	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family	This family includes: Ribosomal L7A from metazoa, Ribosomal L8-A and L8-B from fungi, 30S ribosomal protein HS6 from archaebacteria, 40S ribosomal protein S12 from eukaryotes, Ribosomal protein L30 from eukaryotes and archaebacteria. Gadd45 and MyD11 ...	This family includes: Ribosomal L7A from metazoa, Ribosomal L8-A and L8-B from fungi, 30S ribosomal protein HS6 from archaebacteria, 40S ribosomal protein S12 from eukaryotes, Ribosomal protein L30 from eukaryotes and archaebacteria. Gadd45 and MyD118 [1].	Domain
H [auth C]	PF14374	60S ribosomal protein L4 C-terminal domain (Ribos_L4_asso_C)	60S ribosomal protein L4 C-terminal domain	This family is found at the very C-terminal of 60 ribosomal L4 proteins.	Domain
H [auth C]	PF00573	Ribosomal protein L4/L1 family (Ribosomal_L4)	Ribosomal protein L4/L1 family	-	Family
I [auth d]	PF01198	Ribosomal protein L31e (Ribosomal_L31e)	Ribosomal protein L31e	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth s]	nascent chain pre-prolactin	-	-	-
F [auth B]	Ribosomal protein L3	-	-	-
K [auth e]	Ribosomal protein L32	-	-	-
L [auth E]	60S ribosomal protein L6	-	-	-
O [auth g]	60S ribosomal protein L34	-	-	-
Q [auth h]	60S ribosomal protein L35	-	-	-
T [auth I]	60S ribosomal protein L10	-	-	-
U [auth j]	Ribosomal protein L37	-	-	-
DA [auth O]	60S ribosomal protein L13a	-	-	-
NA [auth V]	Ribosomal protein L23	-	-	-
OA [auth W]	Ribosomal protein L24	-	-	-
QA [auth X]	Ribosomal_L23eN domain-containing protein	-	-	-
RA [auth 7]	5S ribosomal RNA	-	-	-
VA [auth a]	60S ribosomal protein L27a	-	-	-
J [auth D]	Ribosomal_L18_c domain-containing protein	RNA binding binding organic cyclic compound binding rRNA binding 5S rRNA binding nucleic acid binding structural molecule activity structural constituent of ribosome	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle cytosolic ribosome ribosome cytoplasm cytosol protein-containing complex ribonucleoprotein complex
M [auth f]	60S ribosomal protein L35a	-	-	-
N [auth F]	uL30	-	-	-
P [auth G]	60S ribosomal protein L7a	-	-	-
R [auth H]	60S ribosomal protein L9	-	-	-
S [auth i]	60S ribosomal protein L36	-	-	-
B [auth t]	Nascent polypeptide-associated complex subunit alpha	DNA binding binding organic cyclic compound binding nucleic acid binding transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity	developmental process heart development multicellular organism development multicellular organismal process cardiac chamber development anatomical structure development animal organ development cardiac ventricle development circulatory system development system development regulation of biological process regulation of cellular process muscle cell apoptotic process negative regulation of programmed cell death developmental process heart development multicellular organism development multicellular organismal process cardiac chamber development anatomical structure development animal organ development cardiac ventricle development circulatory system development system development regulation of biological process regulation of cellular process muscle cell apoptotic process negative regulation of programmed cell death regulation of apoptotic process biological regulation negative regulation of biological process regulation of muscle cell apoptotic process regulation of programmed cell death cell death negative regulation of apoptotic process regulation of striated muscle cell apoptotic process striated muscle cell apoptotic process negative regulation of muscle cell apoptotic process negative regulation of cellular process negative regulation of striated muscle cell apoptotic process cellular process apoptotic process programmed cell death positive regulation of cell population proliferation positive regulation of cell proliferation involved in heart morphogenesis heart morphogenesis positive regulation of biological process animal organ morphogenesis positive regulation of cellular process cell population proliferation anatomical structure morphogenesis cell proliferation involved in heart morphogenesis regulation of cell population proliferation regulation of cell proliferation involved in heart morphogenesis regulation of muscle tissue development regulation of growth regulation of developmental process developmental growth skeletal muscle tissue development positive regulation of skeletal muscle tissue development regulation of skeletal muscle tissue development muscle structure development positive regulation of developmental process skeletal muscle organ development regulation of skeletal muscle tissue growth positive regulation of skeletal muscle tissue growth muscle tissue development muscle organ development positive regulation of developmental growth regulation of developmental growth growth tissue development positive regulation of growth positive regulation of muscle tissue development skeletal muscle tissue growth wound healing response to stimulus response to stress response to wounding protein localization regulation of localization cellular localization regulation of protein localization negative regulation of protein localization to endoplasmic reticulum localization regulation of protein localization to endoplasmic reticulum regulation of cellular localization cellular macromolecule localization macromolecule localization protein localization to organelle protein localization to endoplasmic reticulum negative regulation of protein localization tissue regeneration skeletal muscle tissue regeneration regeneration establishment of protein localization nitrogen compound transport transport organic substance transport establishment of localization protein transport heart trabecula morphogenesis trabecula morphogenesis negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process cellular developmental process cell development regulation of cell differentiation regulation of striated muscle cell differentiation muscle cell differentiation myotube differentiation regulation of cell development regulation of skeletal muscle fiber development muscle cell development cell differentiation regulation of myotube differentiation myotube cell development skeletal muscle fiber development regulation of muscle cell differentiation striated muscle cell differentiation organonitrogen compound metabolic process organonitrogen compound biosynthetic process translation protein metabolic process	extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm nascent polypeptide-associated complex protein-containing complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm nascent polypeptide-associated complex protein-containing complex intracellular organelle nucleus intracellular membrane-bounded organelle
V [auth J]	Ribosomal protein L11	-	-	-
W [auth k]	60S ribosomal protein L38	-	-	-
X [auth L]	L13	-	-	-
Y [auth l]	Ribosomal protein L39	-	-	-
Z [auth M]	60S ribosomal protein L14	-	-	-
AA [auth m]	60S ribosomal protein L40	-	-	-
BA [auth N]	Ribosomal protein L15	-	-	-
CA [auth n]	60s ribosomal protein l41	-	-	-
C [auth u]	Isoform 2 of Transcription factor BTF3	RNA binding binding organic cyclic compound binding nucleic acid binding	developmental process multicellular organism development multicellular organismal process embryo development ending in birth or egg hatching chordate embryonic development anatomical structure development embryo development in utero embryonic development protein localization regulation of localization regulation of biological process cellular localization regulation of cellular process regulation of protein localization developmental process multicellular organism development multicellular organismal process embryo development ending in birth or egg hatching chordate embryonic development anatomical structure development embryo development in utero embryonic development protein localization regulation of localization regulation of biological process cellular localization regulation of cellular process regulation of protein localization negative regulation of protein localization to endoplasmic reticulum biological regulation negative regulation of biological process localization regulation of protein localization to endoplasmic reticulum regulation of cellular localization cellular macromolecule localization macromolecule localization protein localization to organelle negative regulation of cellular process cellular process protein localization to endoplasmic reticulum negative regulation of protein localization establishment of protein localization nitrogen compound transport transport organic substance transport establishment of localization protein transport	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol nascent polypeptide-associated complex protein-containing complex membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle
EA [auth o]	eL42	structural molecule activity structural constituent of ribosome	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex ribonucleoprotein complex intracellular organelle organelle intracellular non-membrane-bounded organelle ribosome non-membrane-bounded organelle
FA [auth P]	60S ribosomal protein L17	-	-	-
GA [auth p]	eL43	-	-	-
HA [auth Q]	eL18	structural molecule activity structural constituent of ribosome	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process	protein-containing complex ribonucleoprotein complex intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle ribosome cellular anatomical entity non-membrane-bounded organelle rough endoplasmic reticulum membrane-bounded organelle endoplasmic reticulum cytoplasm intracellular membrane-bounded organelle protein-containing complex ribonucleoprotein complex intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle ribosome cellular anatomical entity non-membrane-bounded organelle rough endoplasmic reticulum membrane-bounded organelle endoplasmic reticulum cytoplasm intracellular membrane-bounded organelle endomembrane system
IA [auth r]	60S ribosomal protein L28	-	-	-
JA [auth R]	60S ribosomal protein L19	RNA binding binding organic cyclic compound binding nucleic acid binding structural molecule activity structural constituent of ribosome	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process	protein-containing complex intracellular anatomical structure cellular anatomical entity intracellular organelle ribosomal subunit cytosolic large ribosomal subunit cytosolic ribosome organelle ribonucleoprotein complex intracellular non-membrane-bounded organelle ribosome cytoplasm cytosol large ribosomal subunit protein-containing complex intracellular anatomical structure cellular anatomical entity intracellular organelle ribosomal subunit cytosolic large ribosomal subunit cytosolic ribosome organelle ribonucleoprotein complex intracellular non-membrane-bounded organelle ribosome cytoplasm cytosol large ribosomal subunit non-membrane-bounded organelle
KA [auth S]	60S ribosomal protein L18a	-	-	-
LA [auth T]	60S ribosomal protein L21	-	-	-
MA [auth U]	60S ribosomal protein L22	-	-	-
D [auth A]	60S ribosomal protein L8	structural molecule activity structural constituent of ribosome	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process	protein-containing complex ribonucleoprotein complex intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle ribosome cellular anatomical entity non-membrane-bounded organelle
PA [auth 5]	28S rRNA	-	-	-
SA [auth Y]	Ribosomal protein L26	-	-	-
TA [auth 8]	5.8S ribosomal RNA	-	-	-
UA [auth Z]	60S ribosomal protein L27	-	-	-
E [auth b]	60S ribosomal protein L29	-	-	-
G [auth c]	60S ribosomal protein L30	-	-	-
H [auth C]	60S ribosomal protein L4	-	-	-
I [auth d]	Ribosomal protein L31	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
J [auth D]	IPR005485	Large ribosomal subunit protein uL18 eukaryotic/archaeal	Family
J [auth D]	IPR025607	Large ribosomal subunit protein uL18, C-terminal, eukaryotes	Domain
B [auth t]	IPR038187	NAC A/B domain superfamily	Homologous Superfamily
B [auth t]	IPR044034	Nascent polypeptide-associated complex subunit alpha-like, UBA domain	Domain
B [auth t]	IPR016641	Nascent polypeptide-associated complex subunit alpha-like	Family
B [auth t]	IPR002715	Nascent polypeptide-associated complex NAC domain	Domain
C [auth u]	IPR039370	Transcription factor BTF3	Family
C [auth u]	IPR038187	NAC A/B domain superfamily	Homologous Superfamily
C [auth u]	IPR002715	Nascent polypeptide-associated complex NAC domain	Domain
EA [auth o]	IPR011332	Zinc-binding ribosomal protein	Homologous Superfamily
EA [auth o]	IPR000552	Large ribosomal subunit protein eL42	Family
HA [auth Q]	IPR021131	Large ribosomal subunit protein uL15/eL18	Domain
HA [auth Q]	IPR021132	Large ribosomal subunit protein eL18, conserved site	Conserved Site
HA [auth Q]	IPR000039	Large ribosomal subunit protein eL18	Family
HA [auth Q]	IPR036227	Large ribosomal subunit protein uL15/eL18 superfamily	Homologous Superfamily
JA [auth R]	IPR015972	Large ribosomal subunit protein eL19, domain 1	Homologous Superfamily
JA [auth R]	IPR039547	Large ribosomal subunit protein eL19	Family
JA [auth R]	IPR023638	Large ribosomal subunit protein eL19, conserved site	Conserved Site
JA [auth R]	IPR035970	Large ribosomal subunit protein eL19 superfamily	Homologous Superfamily
JA [auth R]	IPR000196	Large ribosomal subunit protein eL19 domain	Domain
JA [auth R]	IPR033935	Large ribosomal subunit protein eL19, eukaryotic	Domain
D [auth A]	IPR022671	Large ribosomal subunit protein uL2, conserved site	Conserved Site
D [auth A]	IPR022669	Large ribosomal subunit protein uL2, C-terminal	Domain
D [auth A]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
D [auth A]	IPR014722	Large ribosomal subunit protein uL2, domain 2	Homologous Superfamily
D [auth A]	IPR008991	Translation protein SH3-like domain superfamily	Homologous Superfamily
D [auth A]	IPR014726	Large ribosomal subunit protein uL2, domain 3	Homologous Superfamily
D [auth A]	IPR002171	Large ribosomal subunit protein uL2	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B [auth t]	Pharos: Q13765	atrial fibrillation adrenal cortex carcinoma lung cancer malignant mesothelioma ovarian cancer lymphoplasmacytic lymphoma myopathy pancreatic intraductal papillary-mucinous neoplasm invasive ductal breast carcinoma malignant colon neoplasm osteosarcoma plasma cell myeloma
C [auth u]	Pharos: P20290	breast cancer medulloblastoma large cell medulloblastoma ovarian cancer lymphoplasmacytic lymphoma plasma cell myeloma