Annotations: 7Q6Z

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	PF07686	e7q6zB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF03062	MBOAT, membrane-bound O-acyltransferase family (MBOAT)	MBOAT, membrane-bound O-acyltransferase family	-	Family
B	PF01204	Trehalase (Trehalase)	Trehalase	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Protein-cysteine N-palmitoyltransferase HHAT	binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding organic cyclic compound binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding organic cyclic compound binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding O-acyltransferase activity acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity catalytic activity palmitoyltransferase activity	cellular biosynthetic process lipoprotein biosynthetic process lipoprotein metabolic process organonitrogen compound biosynthetic process N-terminal protein lipidation protein acylation protein lipidation organic substance metabolic process protein palmitoylation peptidyl-amino acid modification organic substance biosynthetic process protein metabolic process protein modification process organonitrogen compound metabolic process cellular biosynthetic process lipoprotein biosynthetic process lipoprotein metabolic process organonitrogen compound biosynthetic process N-terminal protein lipidation protein acylation protein lipidation organic substance metabolic process protein palmitoylation peptidyl-amino acid modification organic substance biosynthetic process protein metabolic process protein modification process organonitrogen compound metabolic process peptidyl-cysteine modification cellular metabolic process primary metabolic process N-terminal protein palmitoylation macromolecule biosynthetic process N-terminal peptidyl-L-cysteine N-palmitoylation biosynthetic process N-terminal protein amino acid modification macromolecule modification metabolic process cellular process macromolecule metabolic process cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling biological regulation smoothened signaling pathway cell communication signal transduction	membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle endomembrane system Golgi membrane membrane bounding membrane of organelle organelle membrane endoplasmic reticulum membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle endomembrane system Golgi membrane membrane bounding membrane of organelle organelle membrane endoplasmic reticulum organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum membrane
B	Megabody 177	hydrolase activity, acting on glycosyl bonds alpha,alpha-trehalase activity hydrolase activity, hydrolyzing O-glycosyl compounds hydrolase activity trehalase activity catalytic activity glucosidase activity cation binding ion binding binding metal ion binding small molecule binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process carbohydrate metabolic process trehalose catabolic process catabolic process trehalose metabolic process oligosaccharide catabolic process oligosaccharide metabolic process carbohydrate catabolic process primary metabolic process cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process carbohydrate metabolic process trehalose catabolic process catabolic process trehalose metabolic process oligosaccharide catabolic process oligosaccharide metabolic process carbohydrate catabolic process primary metabolic process disaccharide metabolic process organic substance metabolic process metabolic process organic substance catabolic process disaccharide catabolic process	protein-containing complex catalytic complex glucosidase complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR004299	Membrane bound O-acyl transferase, MBOAT	Family
B	IPR012341	Six-hairpin glycosidase-like superfamily	Homologous Superfamily
B	IPR048450	Glucosidase YgjK, N-terminal domain	Domain
B	IPR001661	Glycoside hydrolase, family 37	Family
B	IPR008928	Six-hairpin glycosidase superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q5VTY9	chondrodysplasia-pseudohermaphroditism syndrome gastrointestinal stromal tumor astrocytic tumor ductal breast carcinoma in situ malignant ependymoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia medulloblastoma schizophrenia Disorders of Sex Development interstitial cystitis ovarian cancer subependymal giant cell astrocytoma

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B	OPM				Membrane-bound O-acyltransferase

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	O-acyltransferases	Hedgehog acyltransferase (HHAT) in complex with megabody 177 bound to non-hydrolysable palmitoyl-CoA (Composite Map)

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.