Annotations: 7Q3Z

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth B]	PF04326	e7q3zB2	A: a+b two layers	X: IF3-like	H: Schlafen 8 (From Topology)	T: Schlafen 8	F: PF04326	ECOD (1.6)
A [auth B]	PF17057	e7q3zB1	A: a+b two layers	X: IF3-like	H: Schlafen 8 (From Topology)	T: Schlafen 8	F: PF17057	ECOD (1.6)
B [auth A]	PF04326	e7q3zA1	A: a+b two layers	X: IF3-like	H: Schlafen 8 (From Topology)	T: Schlafen 8	F: PF04326	ECOD (1.6)
B [auth A]	PF17057	e7q3zA2	A: a+b two layers	X: IF3-like	H: Schlafen 8 (From Topology)	T: Schlafen 8	F: PF17057	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B], B [auth A]	PF17057	Poxviridae B3 protein (B3R)	Poxviridae B3 protein	-	Family
A [auth B], B [auth A]	PF04326	Schlafen, AlbA_2 (SLFN_AlbA_2)	Schlafen, AlbA_2	This is the AlbA_2 domain from the Schlafen (SLFN) family of proteins which are important in cell differentiation and defense against viruses [1,2]. This domain is present at the N-terminal of all SLFN proteins and includes the SLFN box, a sequence u ...	This is the AlbA_2 domain from the Schlafen (SLFN) family of proteins which are important in cell differentiation and defense against viruses [1,2]. This domain is present at the N-terminal of all SLFN proteins and includes the SLFN box, a sequence unique to these proteins that may form a dimer interface [1]. The AlbA_2 domain is RNA-binding and RNase region as it contains the highly conserved catalytic glutamic acid residues [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B], B [auth A]	Schlafen family member 5	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding	developmental process cellular developmental process cell differentiation cellular process	membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle nucleus intracellular membrane-bounded organelle cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B], B [auth A]	IPR031450	Poxin-Schlafen/Schlafen-like, N-terminal domain	Domain
A [auth B], B [auth A]	IPR029684	Schlafen family	Family
A [auth B], B [auth A]	IPR018647	Schlafen group 3-like, DNA/RNA helicase domain	Domain
A [auth B], B [auth A]	IPR007421	Schlafen, AlbA_2 domain	Domain
A [auth B], B [auth A]	IPR048729	Schlafen, GTPase-like domain	Domain
A [auth B], B [auth A]	IPR038461	Schlafen, AlbA_2 domain superfamily	Homologous Superfamily
A [auth B], B [auth A]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth B], B [auth A]	Pharos: Q08AF3	atypical teratoid rhabdoid tumor hepatocellular carcinoma malignant ependymoma oligodendroglioma pancreatic ductal adenocarcinoma sarcoidosis tuberculosis cystic fibrosis juvenile dermatomyositis malignant glioma osteosarcoma Pick disease Sjogren syndrome ulcerative colitis glioblastoma atypical teratoid rhabdoid tumor hepatocellular carcinoma malignant ependymoma oligodendroglioma pancreatic ductal adenocarcinoma sarcoidosis tuberculosis cystic fibrosis juvenile dermatomyositis malignant glioma osteosarcoma Pick disease Sjogren syndrome ulcerative colitis glioblastoma lung carcinoma myopathy ovarian cancer psoriasis subependymal giant cell astrocytoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.