7PMK

S. cerevisiae replisome-SCF(Dia2) complex bound to double-stranded DNA (conformation I)

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
Q [auth K]	SCOP2B Superfamily	Skp1 dimerisation domain-like	8043773	3000564	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth 2]	PF17207	e7pmk25	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF17207	ECOD (1.6)
A [auth 2]	PF17855	e7pmk21	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17855	ECOD (1.6)
A [auth 2]	PF14551	e7pmk24	A: a+b complex topology	X: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	H: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	T: N-terminal subdomain in DNA replication initiator (cdc21/cdc54)	F: PF14551	ECOD (1.6)
A [auth 2]	PF00493	e7pmk22	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00493	ECOD (1.6)
A [auth 2]	F_UNCLASSIFIED	e7pmk23	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: F_UNCLASSIFIED	ECOD (1.6)
J [auth D]	PF05916	e7pmkD1	A: alpha bundles	X: GINS helical bundle-like (From Homology)	H: GINS helical bundle-like	T: PSF1 N-terminal domain-like	F: PF05916	ECOD (1.6)
J [auth D]	PF16922	e7pmkD2	A: a+b two layers	X: L9 N-domain-like	H: GINS/PriA/YqbF domain (From Topology)	T: GINS/PriA/YqbF domain	F: PF16922	ECOD (1.6)
K [auth E]	PF02724	e7pmkE2	A: alpha arrays	X: HhH/H2TH	H: Cdc45 CID domain (From Topology)	T: Cdc45 CID domain	F: PF02724	ECOD (1.6)
K [auth E]	PF02724	e7pmkE3	A: a+b three layers	X: C-terminal domain in DHH phosphoesterases (From Topology)	H: C-terminal domain in DHH phosphoesterases (From Topology)	T: C-terminal domain in DHH phosphoesterases	F: PF02724	ECOD (1.6)
K [auth E]	PF02724	e7pmkE1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: DHH phosphoesterases	F: PF02724	ECOD (1.6)
L [auth F]	PF12341	e7pmkF1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF12341	ECOD (1.6)
L [auth F]	PF20946	e7pmkF2	A: alpha superhelices	X: Repetitive alpha hairpins	H: DNA polymerase alpha-binding protein Ctf4 C-terminal domain (From Topology)	T: DNA polymerase alpha-binding protein Ctf4 C-terminal domain	F: PF20946	ECOD (1.6)
M [auth G]	PF12341	e7pmkG1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF12341	ECOD (1.6)
M [auth G]	PF20946	e7pmkG2	A: alpha superhelices	X: Repetitive alpha hairpins	H: DNA polymerase alpha-binding protein Ctf4 C-terminal domain (From Topology)	T: DNA polymerase alpha-binding protein Ctf4 C-terminal domain	F: PF20946	ECOD (1.6)
N [auth H]	PF12341	e7pmkH1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF12341	ECOD (1.6)
N [auth H]	PF20946	e7pmkH2	A: alpha superhelices	X: Repetitive alpha hairpins	H: DNA polymerase alpha-binding protein Ctf4 C-terminal domain (From Topology)	T: DNA polymerase alpha-binding protein Ctf4 C-terminal domain	F: PF20946	ECOD (1.6)
Q [auth K]	PF01466,PF03931	e7pmkK1	A: a+b two layers	X: POZ domain (From Topology)	H: POZ domain (From Topology)	T: POZ domain	F: PF01466,PF03931	ECOD (1.6)
T [auth R]	F_UNCLASSIFIED	e7pmkR3	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: F_UNCLASSIFIED	ECOD (1.6)
T [auth R]	F_UNCLASSIFIED	e7pmkR2	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: F_UNCLASSIFIED	ECOD (1.6)
T [auth R]	PF04042	e7pmkR1	A: a+b four layers	X: Carbon-nitrogen hydrolase-like	H: Metallo-dependent phosphatases (From Topology)	T: Metallo-dependent phosphatases	F: PF04042	ECOD (1.6)
B [auth 3]	PF17207	e7pmk35	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF17207	ECOD (1.6)
B [auth 3]	PF17855	e7pmk31	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17855	ECOD (1.6)
B [auth 3]	PF14551	e7pmk33	A: a+b complex topology	X: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	H: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	T: N-terminal subdomain in DNA replication initiator (cdc21/cdc54)	F: PF14551	ECOD (1.6)
B [auth 3]	PF00493	e7pmk34	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00493	ECOD (1.6)
B [auth 3]	F_UNCLASSIFIED	e7pmk32	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: F_UNCLASSIFIED	ECOD (1.6)
C [auth 4]	PF17207	e7pmk45	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF17207	ECOD (1.6)
C [auth 4]	PF17855	e7pmk42	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17855	ECOD (1.6)
C [auth 4]	PF14551	e7pmk43	A: a+b complex topology	X: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	H: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	T: N-terminal subdomain in DNA replication initiator (cdc21/cdc54)	F: PF14551	ECOD (1.6)
C [auth 4]	PF00493	e7pmk44	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00493	ECOD (1.6)
C [auth 4]	PF17207	e7pmk41	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: PF17207	ECOD (1.6)
D [auth 5]	PF17207	e7pmk52	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF17207	ECOD (1.6)
D [auth 5]	PF17855	e7pmk51	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17855	ECOD (1.6)
D [auth 5]	PF21933	e7pmk53	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF21933	ECOD (1.6)
D [auth 5]	PF14551	e7pmk55	A: a+b complex topology	X: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	H: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	T: N-terminal subdomain in DNA replication initiator (cdc21/cdc54)	F: PF14551	ECOD (1.6)
D [auth 5]	PF00493	e7pmk54	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00493	ECOD (1.6)
D [auth 5]	F_UNCLASSIFIED	e7pmk56	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: F_UNCLASSIFIED	ECOD (1.6)
E [auth 6]	PF17207	e7pmk65	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF17207	ECOD (1.6)
E [auth 6]	PF17855	e7pmk63	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17855	ECOD (1.6)
E [auth 6]	PF14551	e7pmk64	A: a+b complex topology	X: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	H: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	T: N-terminal subdomain in DNA replication initiator (cdc21/cdc54)	F: PF14551	ECOD (1.6)
E [auth 6]	PF00493	e7pmk61	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00493	ECOD (1.6)
E [auth 6]	PF17207	e7pmk62	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: PF17207	ECOD (1.6)
F [auth 7]	PF17207	e7pmk72	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF17207	ECOD (1.6)
F [auth 7]	PF17855	e7pmk75	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17855	ECOD (1.6)
F [auth 7]	PF14551	e7pmk74	A: a+b complex topology	X: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	H: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	T: N-terminal subdomain in DNA replication initiator (cdc21/cdc54)	F: PF14551	ECOD (1.6)
F [auth 7]	PF00493	e7pmk73	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00493	ECOD (1.6)
F [auth 7]	F_UNCLASSIFIED	e7pmk71	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: F_UNCLASSIFIED	ECOD (1.6)
G [auth A]	PF05916	e7pmkA1	A: alpha bundles	X: GINS helical bundle-like (From Homology)	H: GINS helical bundle-like	T: PSF1 N-terminal domain-like	F: PF05916	ECOD (1.6)
G [auth A]	F_UNCLASSIFIED	e7pmkA2	A: a+b two layers	X: L9 N-domain-like	H: GINS/PriA/YqbF domain (From Topology)	T: GINS/PriA/YqbF domain	F: F_UNCLASSIFIED	ECOD (1.6)
H [auth B]	PF05916	e7pmkB1	A: alpha bundles	X: GINS helical bundle-like (From Homology)	H: GINS helical bundle-like	T: PSF2 C-terminal domain-like	F: PF05916	ECOD (1.6)
H [auth B]	F_UNCLASSIFIED	e7pmkB2	A: a+b two layers	X: L9 N-domain-like	H: GINS/PriA/YqbF domain (From Topology)	T: GINS/PriA/YqbF domain	F: F_UNCLASSIFIED	ECOD (1.6)
I [auth C]	PF05916	e7pmkC1	A: alpha bundles	X: GINS helical bundle-like (From Homology)	H: GINS helical bundle-like	T: PSF2 C-terminal domain-like	F: PF05916	ECOD (1.6)
I [auth C]	PF22466	e7pmkC2	A: a+b two layers	X: L9 N-domain-like	H: GINS/PriA/YqbF domain (From Topology)	T: GINS/PriA/YqbF domain	F: PF22466	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth 2]	PF14551	MCM N-terminal domain (MCM_N)	MCM N-terminal domain	This family contains the N-terminal domain of MCM proteins.	Domain
A [auth 2]	PF00493	MCM P-loop domain (MCM)	MCM P-loop domain	-	Domain
A [auth 2]	PF12619	Mini-chromosome maintenance protein 2 (MCM2_N)	Mini-chromosome maintenance protein 2	-	Family
A [auth 2]	PF17855	MCM AAA-lid domain (MCM_lid)	MCM AAA-lid domain	This entry represents the AAA-lid domain found in MCM proteins.	Domain
A [auth 2]	PF17207	MCM OB domain (MCM_OB)	MCM OB domain	This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif [2].	Domain
J [auth D]	PF05916	GINS complex protein helical bundle domain (Sld5)	GINS complex protein helical bundle domain	This entry represents the C-terminal alpha helical bundle domain. The eukaryotic GINS complex is essential for the initiation and elongation phases of DNA replication [1-3]. It consists of four paralogous protein subunits (Sld5, Psf1, Psf2 and Psf3) ...	This entry represents the C-terminal alpha helical bundle domain. The eukaryotic GINS complex is essential for the initiation and elongation phases of DNA replication [1-3]. It consists of four paralogous protein subunits (Sld5, Psf1, Psf2 and Psf3), all of which are included in this family. The GINS complex is conserved from yeast to humans, and has been shown in human to bind directly to DNA primase [4].	Domain
J [auth D]	PF16922	DNA replication complex GINS protein SLD5 C-terminus (SLD5_C)	DNA replication complex GINS protein SLD5 C-terminus	The C-terminal domain of DNA replication complex GINS protein SLD5 is important in the assembly of the GINS complex, a complex which is involved in initiation of DNA replication and progression of DNA replication forks [1].	Domain
K [auth E]	PF02724	CDC45-like protein (CDC45)	CDC45-like protein	-	Family
L [auth F], M [auth G], N [auth H]	PF12341	Minichromosome loss protein, Mcl1, middle region (Mcl1_mid)	Minichromosome loss protein, Mcl1, middle region	-	Repeat
L [auth F], M [auth G], N [auth H]	PF20946	DNA polymerase alpha-binding protein Ctf4, C-terminal domain (Ctf4_C)	DNA polymerase alpha-binding protein Ctf4, C-terminal domain	This domain is found at the C-terminal end of DNA polymerase alpha- binding protein Ctf4 from yeast, its human orthologue AND1, and similar proteins from eukaryotes. This accessory factor for DNA replication plays a role in accurately duplicating the ...	This domain is found at the C-terminal end of DNA polymerase alpha- binding protein Ctf4 from yeast, its human orthologue AND1, and similar proteins from eukaryotes. This accessory factor for DNA replication plays a role in accurately duplicating the genome in vivo. This domain folds into a helical extension that is linked to the beta-propeller domain (Pfam:PF12341) and protrudes from one face of the disk-shaped trimer formed by the protein. It is essential for binding of dynamic partner proteins, such as Pol alpha-primase [1-4].	Domain
Q [auth K]	PF01466	Skp1 family, dimerisation domain (Skp1)	Skp1 family, dimerisation domain	-	Domain
R [auth L]	PF00646	F-box domain (F-box)	F-box domain	This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; Pfam:PF00560 and Pfam:PF07 ...	This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; Pfam:PF00560 and Pfam:PF07723) and the WD repeat (Pfam:PF00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression [1-2].	Domain
S [auth Q]	PF08490	Domain of unknown function (DUF1744) (DUF1744)	Domain of unknown function (DUF1744)	This domain is found at the C-terminal of the epsilon catalytic subunit of DNA polymerase. It is found C terminal to Pfam:PF03104 and Pfam:PF00136.	Domain
T [auth R]	PF04042	DNA polymerase alpha/epsilon subunit B (DNA_pol_E_B)	DNA polymerase alpha/epsilon subunit B	-	Family
U [auth X]	PF04821	Timeless protein (TIMELESS)	Timeless protein	-	Family
B [auth 3]	PF14551	MCM N-terminal domain (MCM_N)	MCM N-terminal domain	This family contains the N-terminal domain of MCM proteins.	Domain
B [auth 3]	PF00493	MCM P-loop domain (MCM)	MCM P-loop domain	-	Domain
B [auth 3]	PF17855	MCM AAA-lid domain (MCM_lid)	MCM AAA-lid domain	This entry represents the AAA-lid domain found in MCM proteins.	Domain
B [auth 3]	PF17207	MCM OB domain (MCM_OB)	MCM OB domain	This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif [2].	Domain
V [auth Y]	PF07962	Replication Fork Protection Component Swi3 (Swi3)	Replication Fork Protection Component Swi3	-	Family
C [auth 4]	PF14551	MCM N-terminal domain (MCM_N)	MCM N-terminal domain	This family contains the N-terminal domain of MCM proteins.	Domain
C [auth 4]	PF00493	MCM P-loop domain (MCM)	MCM P-loop domain	-	Domain
C [auth 4]	PF17855	MCM AAA-lid domain (MCM_lid)	MCM AAA-lid domain	This entry represents the AAA-lid domain found in MCM proteins.	Domain
C [auth 4]	PF17207	MCM OB domain (MCM_OB)	MCM OB domain	This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif [2].	Domain
D [auth 5]	PF00493	MCM P-loop domain (MCM)	MCM P-loop domain	-	Domain
D [auth 5]	PF17855	MCM AAA-lid domain (MCM_lid)	MCM AAA-lid domain	This entry represents the AAA-lid domain found in MCM proteins.	Domain
D [auth 5]	PF17207	MCM OB domain (MCM_OB)	MCM OB domain	This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif [2].	Domain
E [auth 6]	PF14551	MCM N-terminal domain (MCM_N)	MCM N-terminal domain	This family contains the N-terminal domain of MCM proteins.	Domain
E [auth 6]	PF00493	MCM P-loop domain (MCM)	MCM P-loop domain	-	Domain
E [auth 6]	PF17855	MCM AAA-lid domain (MCM_lid)	MCM AAA-lid domain	This entry represents the AAA-lid domain found in MCM proteins.	Domain
E [auth 6]	PF17207	MCM OB domain (MCM_OB)	MCM OB domain	This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif [2].	Domain
F [auth 7]	PF14551	MCM N-terminal domain (MCM_N)	MCM N-terminal domain	This family contains the N-terminal domain of MCM proteins.	Domain
F [auth 7]	PF00493	MCM P-loop domain (MCM)	MCM P-loop domain	-	Domain
F [auth 7]	PF17855	MCM AAA-lid domain (MCM_lid)	MCM AAA-lid domain	This entry represents the AAA-lid domain found in MCM proteins.	Domain
F [auth 7]	PF17207	MCM OB domain (MCM_OB)	MCM OB domain	This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif [2].	Domain
G [auth A]	PF05916	GINS complex protein helical bundle domain (Sld5)	GINS complex protein helical bundle domain	This entry represents the C-terminal alpha helical bundle domain. The eukaryotic GINS complex is essential for the initiation and elongation phases of DNA replication [1-3]. It consists of four paralogous protein subunits (Sld5, Psf1, Psf2 and Psf3) ...	This entry represents the C-terminal alpha helical bundle domain. The eukaryotic GINS complex is essential for the initiation and elongation phases of DNA replication [1-3]. It consists of four paralogous protein subunits (Sld5, Psf1, Psf2 and Psf3), all of which are included in this family. The GINS complex is conserved from yeast to humans, and has been shown in human to bind directly to DNA primase [4].	Domain
H [auth B]	PF05916	GINS complex protein helical bundle domain (Sld5)	GINS complex protein helical bundle domain	This entry represents the C-terminal alpha helical bundle domain. The eukaryotic GINS complex is essential for the initiation and elongation phases of DNA replication [1-3]. It consists of four paralogous protein subunits (Sld5, Psf1, Psf2 and Psf3) ...	This entry represents the C-terminal alpha helical bundle domain. The eukaryotic GINS complex is essential for the initiation and elongation phases of DNA replication [1-3]. It consists of four paralogous protein subunits (Sld5, Psf1, Psf2 and Psf3), all of which are included in this family. The GINS complex is conserved from yeast to humans, and has been shown in human to bind directly to DNA primase [4].	Domain
I [auth C]	PF05916	GINS complex protein helical bundle domain (Sld5)	GINS complex protein helical bundle domain	This entry represents the C-terminal alpha helical bundle domain. The eukaryotic GINS complex is essential for the initiation and elongation phases of DNA replication [1-3]. It consists of four paralogous protein subunits (Sld5, Psf1, Psf2 and Psf3) ...	This entry represents the C-terminal alpha helical bundle domain. The eukaryotic GINS complex is essential for the initiation and elongation phases of DNA replication [1-3]. It consists of four paralogous protein subunits (Sld5, Psf1, Psf2 and Psf3), all of which are included in this family. The GINS complex is conserved from yeast to humans, and has been shown in human to bind directly to DNA primase [4].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth 2]	DNA replication licensing factor MCM2	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding protein-containing complex binding chromatin binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding protein-containing complex binding chromatin binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity ATP-dependent activity, acting on DNA DNA helicase activity catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid single-stranded DNA helicase activity helicase activity 3'-5' DNA helicase activity cation binding metal ion binding single-stranded DNA binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process DNA-templated DNA replication sexual reproduction reproductive process meiotic cell cycle nuclear DNA replication cell cycle DNA replication primary metabolic process DNA metabolic process cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process DNA-templated DNA replication sexual reproduction reproductive process meiotic cell cycle nuclear DNA replication cell cycle DNA replication primary metabolic process DNA metabolic process meiotic cell cycle process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process premeiotic DNA replication metabolic process macromolecule metabolic process cell cycle cell cycle process pre-replicative complex assembly cellular component organization cellular component biogenesis protein-DNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis pre-replicative complex assembly involved in nuclear cell cycle DNA replication protein-containing complex organization pre-replicative complex assembly involved in cell cycle DNA replication protein-DNA complex assembly double-strand break repair DNA recombination double-strand break repair via break-induced replication recombinational repair double-strand break repair via homologous recombination DNA repair DNA strand elongation DNA strand elongation involved in DNA replication mitotic DNA replication DNA replication initiation cell cycle DNA replication initiation mitotic DNA replication initiation mitotic cell cycle nuclear cell cycle DNA replication initiation mitotic cell cycle process DNA duplex unwinding DNA geometric change chromosome organization DNA conformation change DNA unwinding involved in DNA replication organelle organization	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle intracellular non-membrane-bounded organelle CMG complex nuclear lumen non-membrane-bounded organelle replication fork protection complex nuclear replication fork replication fork cytoplasm MCM complex pre-replicative complex nuclear pre-replicative complex
J [auth D]	DNA replication complex GINS protein SLD5	-	nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA-templated DNA replication DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process DNA duplex unwinding DNA geometric change chromosome organization DNA conformation change nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA-templated DNA replication DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process DNA duplex unwinding DNA geometric change chromosome organization DNA conformation change DNA unwinding involved in DNA replication cellular component organization organelle organization cellular process cellular component organization or biogenesis cellular response to stimulus double-strand break repair response to stimulus DNA recombination double-strand break repair via break-induced replication cellular response to stress DNA damage response response to stress recombinational repair double-strand break repair via homologous recombination DNA repair	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle intracellular non-membrane-bounded organelle CMG complex nuclear lumen non-membrane-bounded organelle GINS complex replication fork protection complex nuclear replication fork replication fork
K [auth E]	Cell division control protein 45,Cell division control protein 45	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding protein-containing complex binding chromatin binding single-stranded DNA binding	DNA-templated DNA replication DNA replication initiation primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process macromolecule metabolic process mitotic DNA replication DNA replication preinitiation complex assembly nuclear DNA replication DNA-templated DNA replication DNA replication initiation primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process macromolecule metabolic process mitotic DNA replication DNA replication preinitiation complex assembly nuclear DNA replication cell cycle DNA replication mitotic cell cycle cellular component organization cellular component biogenesis protein-DNA complex organization mitotic DNA replication preinitiation complex assembly cellular component assembly protein-containing complex assembly cell cycle cellular component organization or biogenesis cell cycle process protein-containing complex organization protein-DNA complex assembly mitotic cell cycle process cellular process DNA duplex unwinding DNA geometric change chromosome organization DNA conformation change DNA unwinding involved in DNA replication organelle organization cellular response to stimulus double-strand break repair response to stimulus DNA recombination double-strand break repair via break-induced replication cellular response to stress DNA damage response response to stress recombinational repair double-strand break repair via homologous recombination DNA repair	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle intracellular non-membrane-bounded organelle CMG complex nuclear lumen non-membrane-bounded organelle replication fork protection complex nuclear replication fork replication fork
L [auth F], M [auth G], N [auth H]	DNA polymerase alpha-binding protein	protein-containing complex binding chromatin binding binding identical protein binding protein binding	cellular process cell cycle mitotic cell cycle protein-containing complex organization protein-DNA complex assembly protein-DNA complex organization cellular component organization cellular component biogenesis cellular component assembly chromatin organization protein-containing complex assembly chromatin remodeling cellular component organization or biogenesis nucleosome assembly cellular process cell cycle mitotic cell cycle protein-containing complex organization protein-DNA complex assembly protein-DNA complex organization cellular component organization cellular component biogenesis cellular component assembly chromatin organization protein-containing complex assembly chromatin remodeling cellular component organization or biogenesis nucleosome assembly nucleosome organization DNA-templated DNA replication DNA replication initiation primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process macromolecule metabolic process cellular response to stimulus response to stimulus cellular response to stress DNA damage response response to stress DNA repair organelle organization mitotic sister chromatid cohesion chromosome organization sister chromatid cohesion cell cycle process double-strand break repair DNA recombination double-strand break repair via break-induced replication recombinational repair double-strand break repair via homologous recombination establishment of sister chromatid cohesion	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle replication fork protection complex protein-containing complex nuclear protein-containing complex nuclear replication fork replication fork Cul8-RING ubiquitin ligase complex cullin-RING ubiquitin ligase complex ubiquitin ligase complex catalytic complex transferase complex intracellular protein-containing complex
O [auth I]	Leading strand template DNA	-	-	-
P [auth J]	Lagging strand template DNA	-	-	-
Q [auth K]	E3 ubiquitin ligase complex SCF subunit	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding protein binding cullin family protein binding	regulation of biological process regulation of cellular process regulation of cellular component organization protein-containing complex organization biological regulation regulation of cellular component biogenesis cellular component biogenesis cellular component organization regulation of protein-containing complex assembly cellular component assembly protein-containing complex assembly cellular process cellular component organization or biogenesis cell cycle regulation of biological process regulation of cellular process regulation of cellular component organization protein-containing complex organization biological regulation regulation of cellular component biogenesis cellular component biogenesis cellular component organization regulation of protein-containing complex assembly cellular component assembly protein-containing complex assembly cellular process cellular component organization or biogenesis cell cycle mitotic cell cycle cellular biosynthetic process organonitrogen compound biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process post-transcriptional regulation of gene expression negative regulation of translation organic substance metabolic process organic substance biosynthetic process negative regulation of cellular process protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process organonitrogen compound metabolic process cellular metabolic process regulation of protein metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process translation gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of cytoplasmic translation negative regulation of biosynthetic process regulation of translation negative regulation of macromolecule biosynthetic process cytoplasmic translation metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of cytoplasmic translation regulation of metabolic process regulation of mitotic cell cycle regulation of cell cycle organelle fusion organelle organization mitochondrial fusion mitochondrion organization proton-transporting V-type ATPase complex assembly vacuolar proton-transporting V-type ATPase complex assembly proton-transporting two-sector ATPase complex assembly organelle assembly non-membrane-bounded organelle assembly chromosome organization protein-DNA complex assembly protein-DNA complex organization kinetochore assembly kinetochore organization centromere complex assembly regulation of cell cycle phase transition cell cycle phase transition exit from mitosis cell cycle process mitotic nuclear division regulation of cell cycle process organelle fission regulation of mitotic cell cycle phase transition nuclear division mitotic cell cycle process regulation of exit from mitosis mitotic cell cycle phase transition chromatin organization chromatin remodeling heterochromatin formation epigenetic regulation of gene expression constitutive heterochromatin formation silent mating-type cassette heterochromatin formation negative regulation of gene expression, epigenetic macromolecule modification post-translational protein modification protein modification process protein neddylation protein modification by small protein conjugation protein modification by small protein conjugation or removal protein ubiquitination organonitrogen compound catabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process organic substance catabolic process septin ring organization septin ring assembly septin cytoskeleton organization cytoskeleton organization oxoacid metabolic process sulfur amino acid metabolic process carboxylic acid metabolic process organic acid metabolic process regulation of sulfur metabolic process regulation of small molecule metabolic process sulfur compound metabolic process small molecule metabolic process regulation of sulfur amino acid metabolic process regulation of localization hexose transmembrane transport transport positive regulation of biological process carbohydrate transport localization positive regulation of transmembrane transport glucose transmembrane transport positive regulation of cellular process positive regulation of glucose transmembrane transport regulation of transport organic substance transport establishment of localization transmembrane transport regulation of glucose transmembrane transport regulation of transmembrane transport positive regulation of transport monosaccharide transmembrane transport carbohydrate transmembrane transport subtelomeric heterochromatin formation telomere organization RNA metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by galactose regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription G1/S transition of mitotic cell cycle cell cycle G1/S phase transition cellular response to stimulus response to organic substance cellular response to chemical stimulus response to stimulus response to chemical cellular response to methylmercury response to methylmercury cellular response to organic substance DNA damage checkpoint signaling signaling negative regulation of cell cycle intracellular signal transduction negative regulation of mitotic cell cycle cell communication mitotic DNA integrity checkpoint signaling cellular response to stress response to stress mitotic DNA damage checkpoint signaling negative regulation of cell cycle phase transition signal transduction mitotic intra-S DNA damage checkpoint signaling DNA integrity checkpoint signaling negative regulation of cell cycle process cell cycle checkpoint signaling mitotic cell cycle checkpoint signaling DNA damage response signal transduction in response to DNA damage cell cycle G2/M phase transition G2/M transition of mitotic cell cycle homeostatic process intracellular pH reduction regulation of intracellular pH vacuolar acidification cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis intracellular chemical homeostasis regulation of biological quality monoatomic cation homeostasis regulation of cellular pH intracellular monoatomic ion homeostasis	cellular anatomical entity endomembrane system protein-containing complex intracellular anatomical structure cytoplasm RAVE complex membrane-bounded organelle nucleus nuclear protein-containing complex chromosome CBF3 complex intracellular membrane-bounded organelle chromosomal region intracellular organelle cellular anatomical entity endomembrane system protein-containing complex intracellular anatomical structure cytoplasm RAVE complex membrane-bounded organelle nucleus nuclear protein-containing complex chromosome CBF3 complex intracellular membrane-bounded organelle chromosomal region intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region non-membrane-bounded organelle cullin-RING ubiquitin ligase complex ubiquitin ligase complex catalytic complex SCF ubiquitin ligase complex transferase complex intracellular protein-containing complex kinetochore condensed chromosome, centromeric region supramolecular complex condensed chromosome chromosome, telomeric region
R [auth L]	Protein DIA2	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process cellular component organization cellular component disassembly protein-containing complex organization protein-containing complex disassembly cellular process cellular component organization or biogenesis subtelomeric heterochromatin formation regulation of cellular process cellular biosynthetic process negative regulation of biological process telomere organization negative regulation of cellular metabolic process protein-DNA complex organization chromatin organization organic substance biosynthetic process negative regulation of cellular process chromatin remodeling negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process heterochromatin formation epigenetic regulation of gene expression cellular metabolic process negative regulation of metabolic process biological regulation chromosome organization regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression organelle organization negative regulation of gene expression constitutive heterochromatin formation biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process regulation of metabolic process invasive growth in response to glucose limitation growth invasive filamentous growth growth of unicellular organism as a thread of attached cells filamentous growth filamentous growth of a population of unicellular organisms DNA metabolic process nucleic acid metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication regulation of nucleobase-containing compound metabolic process regulation of DNA replication regulation of DNA metabolic process silent mating-type cassette heterochromatin formation cellular response to stimulus DNA damage checkpoint signaling regulation of cell cycle phase transition response to stimulus signaling negative regulation of cell cycle cell cycle phase transition intracellular signal transduction mitotic cell cycle negative regulation of mitotic cell cycle cell communication regulation of mitotic cell cycle mitotic DNA integrity checkpoint signaling cellular response to stress response to stress mitotic DNA damage checkpoint signaling negative regulation of cell cycle phase transition signal transduction cell cycle mitotic intra-S DNA damage checkpoint signaling regulation of cell cycle cell cycle process regulation of cell cycle process DNA integrity checkpoint signaling negative regulation of cell cycle process cell cycle checkpoint signaling mitotic cell cycle checkpoint signaling mitotic cell cycle process DNA damage response signal transduction in response to DNA damage protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle chromosome chromosome, telomeric region cellular anatomical entity chromosomal region non-membrane-bounded organelle cullin-RING ubiquitin ligase complex protein-containing complex ubiquitin ligase complex catalytic complex SCF ubiquitin ligase complex intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle chromosome chromosome, telomeric region cellular anatomical entity chromosomal region non-membrane-bounded organelle cullin-RING ubiquitin ligase complex protein-containing complex ubiquitin ligase complex catalytic complex SCF ubiquitin ligase complex transferase complex intracellular protein-containing complex membrane-bounded organelle nucleus intracellular membrane-bounded organelle
S [auth Q]	DNA polymerase epsilon catalytic subunit A	binding nucleoside phosphate binding organic cyclic compound binding nucleotide binding heterocyclic compound binding small molecule binding DNA exonuclease activity catalytic activity, acting on a nucleic acid 3'-5' exonuclease activity hydrolase activity DNA exonuclease activity, producing 5'-phosphomonoesters DNA nuclease activity exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters single-stranded DNA exodeoxyribonuclease activity binding nucleoside phosphate binding organic cyclic compound binding nucleotide binding heterocyclic compound binding small molecule binding DNA exonuclease activity catalytic activity, acting on a nucleic acid 3'-5' exonuclease activity hydrolase activity DNA exonuclease activity, producing 5'-phosphomonoesters DNA nuclease activity exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters single-stranded DNA exodeoxyribonuclease activity catalytic activity, acting on DNA nuclease activity hydrolase activity, acting on ester bonds 3'-5'-DNA exonuclease activity catalytic activity exonuclease activity single-stranded DNA 3'-5' DNA exonuclease activity iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding metal cluster binding DNA-directed DNA polymerase activity DNA polymerase activity transferase activity nucleotidyltransferase activity transferase activity, transferring phosphorus-containing groups DNA binding nucleic acid binding RNA binding mRNA binding double-stranded DNA binding SUMO binding protein binding ubiquitin-like protein binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding single-stranded DNA binding	cellular process cell cycle mitotic cell cycle cellular response to stimulus regulation of cellular process regulation of cell cycle phase transition response to stimulus signaling G2/M transition of mitotic cell cycle negative regulation of biological process negative regulation of cell cycle cell cycle phase transition intracellular signal transduction negative regulation of mitotic cell cycle cellular process cell cycle mitotic cell cycle cellular response to stimulus regulation of cellular process regulation of cell cycle phase transition response to stimulus signaling G2/M transition of mitotic cell cycle negative regulation of biological process negative regulation of cell cycle cell cycle phase transition intracellular signal transduction negative regulation of mitotic cell cycle cell communication mitotic G2/M transition checkpoint regulation of mitotic cell cycle mitotic DNA integrity checkpoint signaling negative regulation of cellular process negative regulation of cell cycle phase transition signal transduction DNA replication checkpoint signaling regulation of cell cycle cell cycle process cell cycle G2/M phase transition regulation of biological process mitotic DNA replication checkpoint signaling negative regulation of mitotic cell cycle phase transition regulation of G2/M transition of mitotic cell cycle regulation of cell cycle process biological regulation DNA integrity checkpoint signaling regulation of cell cycle G2/M phase transition negative regulation of cell cycle process cell cycle checkpoint signaling regulation of mitotic cell cycle phase transition mitotic cell cycle checkpoint signaling mitotic cell cycle process negative regulation of cell cycle G2/M phase transition negative regulation of G2/M transition of mitotic cell cycle mitotic cell cycle phase transition DNA-templated DNA replication primary metabolic process DNA metabolic process leading strand elongation nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA strand elongation organic substance metabolic process DNA replication metabolic process DNA strand elongation involved in DNA replication macromolecule metabolic process DNA-templated DNA replication maintenance of fidelity DNA replication proofreading cellular response to stress DNA damage response response to stress DNA repair postreplication repair cellular biosynthetic process DNA synthesis involved in DNA repair nucleic acid biosynthetic process organic substance biosynthetic process translesion synthesis cellular metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process biosynthetic process organic cyclic compound biosynthetic process error-prone translesion synthesis DNA biosynthetic process base-excision repair cellular component organization organelle organization mitotic sister chromatid cohesion chromosome organization sister chromatid cohesion cellular component organization or biogenesis nucleotide-excision repair, DNA gap filling nucleotide-excision repair base-excision repair, gap-filling double-strand break repair homologous recombination DNA recombination gene conversion DNA damage checkpoint signaling mitotic DNA damage checkpoint signaling mitotic intra-S DNA damage checkpoint signaling signal transduction in response to DNA damage double-strand break repair via nonhomologous end joining	membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome transferase complex intracellular organelle lumen intracellular organelle non-membrane-bounded organelle catalytic complex intracellular membrane-bounded organelle membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome transferase complex intracellular organelle lumen intracellular organelle non-membrane-bounded organelle catalytic complex intracellular membrane-bounded organelle cellular anatomical entity epsilon DNA polymerase complex DNA polymerase complex transferase complex, transferring phosphorus-containing groups organelle lumen organelle intracellular non-membrane-bounded organelle intracellular protein-containing complex nuclear lumen replication fork nuclear replication fork
T [auth R]	DNA polymerase epsilon subunit B	DNA binding binding organic cyclic compound binding nucleic acid binding	cellular process cell cycle cellular response to stimulus postreplication repair response to stimulus cellular biosynthetic process DNA synthesis involved in DNA repair nucleobase-containing compound metabolic process nucleic acid biosynthetic process organic substance metabolic process cellular response to stress response to stress organic substance biosynthetic process DNA repair cellular process cell cycle cellular response to stimulus postreplication repair response to stimulus cellular biosynthetic process DNA synthesis involved in DNA repair nucleobase-containing compound metabolic process nucleic acid biosynthetic process organic substance metabolic process cellular response to stress response to stress organic substance biosynthetic process DNA repair translesion synthesis cellular metabolic process primary metabolic process DNA metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process DNA damage response organic cyclic compound biosynthetic process metabolic process error-prone translesion synthesis macromolecule metabolic process DNA biosynthetic process DNA-templated DNA replication DNA-templated DNA replication maintenance of fidelity DNA replication	intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle nucleus membrane-enclosed lumen nuclear replication fork nuclear chromosome chromosome intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle nucleus membrane-enclosed lumen nuclear replication fork nuclear chromosome chromosome intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle replication fork non-membrane-bounded organelle nuclear lumen protein-containing complex nuclear protein-containing complex transferase complex catalytic complex epsilon DNA polymerase complex DNA polymerase complex transferase complex, transferring phosphorus-containing groups intracellular protein-containing complex
U [auth X]	Topoisomerase 1-associated factor 1	DNA binding binding organic cyclic compound binding nucleic acid binding	nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process chromosome organization maintenance of DNA repeat elements cellular component organization organelle organization cellular process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process chromosome organization maintenance of DNA repeat elements cellular component organization organelle organization cellular process cellular component organization or biogenesis cellular response to stimulus response to stimulus cellular response to stress DNA damage response response to stress DNA repair rhythmic process regulation of biological process entrainment of circadian clock circadian rhythm biological regulation response to external stimulus regulation of circadian rhythm regulation of cellular process regulation of cell cycle phase transition signaling negative regulation of biological process negative regulation of cell cycle cell cycle phase transition intracellular signal transduction cell communication negative regulation of cellular process negative regulation of cell cycle phase transition signal transduction cell cycle DNA replication checkpoint signaling regulation of cell cycle cell cycle process regulation of cell cycle process DNA integrity checkpoint signaling negative regulation of cell cycle process cell cycle checkpoint signaling mitotic sister chromatid cohesion sister chromatid cohesion DNA-templated DNA replication maintenance of fidelity regulation of primary metabolic process negative regulation of DNA-templated DNA replication negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process DNA-templated DNA replication negative regulation of DNA replication negative regulation of metabolic process regulation of macromolecule metabolic process regulation of DNA-templated DNA replication replication fork arrest negative regulation of DNA metabolic process regulation of metabolic process regulation of DNA metabolic process regulation of DNA replication sexual reproduction reproductive process meiotic cell cycle	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle replication fork protection complex protein-containing complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear replication fork nuclear chromosome chromosome intracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle replication fork protection complex protein-containing complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear replication fork nuclear chromosome chromosome intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle replication fork non-membrane-bounded organelle nuclear lumen
B [auth 3]	DNA replication licensing factor MCM3	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding protein-containing complex binding MCM complex binding chromatin binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding protein-containing complex binding MCM complex binding chromatin binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity ATP-dependent activity, acting on DNA DNA helicase activity catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid single-stranded DNA helicase activity helicase activity single-stranded DNA binding	DNA-templated DNA replication DNA replication initiation primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process macromolecule metabolic process sexual reproduction reproductive process meiotic cell cycle DNA-templated DNA replication DNA replication initiation primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process macromolecule metabolic process sexual reproduction reproductive process meiotic cell cycle nuclear DNA replication cell cycle DNA replication meiotic cell cycle process premeiotic DNA replication cellular process cell cycle cell cycle process pre-replicative complex assembly cellular component organization cellular component biogenesis protein-DNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis pre-replicative complex assembly involved in nuclear cell cycle DNA replication protein-containing complex organization pre-replicative complex assembly involved in cell cycle DNA replication protein-DNA complex assembly regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process chromatin organization organic substance biosynthetic process negative regulation of cellular process chromatin remodeling negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process heterochromatin formation epigenetic regulation of gene expression cellular metabolic process negative regulation of metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression constitutive heterochromatin formation biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process silent mating-type cassette heterochromatin formation negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process regulation of metabolic process cellular response to stimulus double-strand break repair response to stimulus DNA recombination double-strand break repair via break-induced replication cellular response to stress DNA damage response response to stress recombinational repair double-strand break repair via homologous recombination DNA repair DNA strand elongation DNA strand elongation involved in DNA replication subtelomeric heterochromatin formation telomere organization chromosome organization organelle organization mitotic DNA replication cell cycle DNA replication initiation mitotic DNA replication initiation mitotic cell cycle nuclear cell cycle DNA replication initiation mitotic cell cycle process DNA duplex unwinding DNA geometric change DNA conformation change DNA unwinding involved in DNA replication	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle intracellular non-membrane-bounded organelle CMG complex nuclear lumen non-membrane-bounded organelle replication fork protection complex nuclear replication fork replication fork cytoplasm MCM complex pre-replicative complex nuclear pre-replicative complex chromosome, telomeric region chromosomal region
V [auth Y]	Chromosome segregation in meiosis protein 3	DNA binding binding organic cyclic compound binding nucleic acid binding	DNA-templated DNA replication DNA-templated DNA replication maintenance of fidelity primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process macromolecule metabolic process replication fork processing chromosome organization maintenance of DNA repeat elements DNA-templated DNA replication DNA-templated DNA replication maintenance of fidelity primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process macromolecule metabolic process replication fork processing chromosome organization maintenance of DNA repeat elements cellular component organization organelle organization cellular process cellular component organization or biogenesis cellular response to stimulus response to stimulus cellular response to stress DNA damage response response to stress DNA repair regulation of cellular process regulation of cell cycle phase transition signaling negative regulation of biological process negative regulation of cell cycle cell cycle phase transition intracellular signal transduction cell communication negative regulation of cellular process negative regulation of cell cycle phase transition signal transduction cell cycle DNA replication checkpoint signaling regulation of cell cycle cell cycle process regulation of biological process regulation of cell cycle process biological regulation DNA integrity checkpoint signaling negative regulation of cell cycle process cell cycle checkpoint signaling mitotic sister chromatid cohesion sister chromatid cohesion meiotic chromosome segregation sexual reproduction reproductive process meiotic cell cycle organelle fission meiotic cell cycle process nuclear division nuclear chromosome segregation meiotic nuclear division chromosome segregation regulation of primary metabolic process negative regulation of DNA-templated DNA replication negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process negative regulation of DNA replication negative regulation of metabolic process regulation of macromolecule metabolic process regulation of DNA-templated DNA replication replication fork arrest negative regulation of DNA metabolic process regulation of metabolic process regulation of DNA metabolic process regulation of DNA replication establishment of mitotic sister chromatid cohesion mitotic cell cycle mitotic cell cycle process establishment of sister chromatid cohesion	membrane-bounded organelle replication fork protection complex protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear replication fork nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle membrane-bounded organelle replication fork protection complex protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear replication fork nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle replication fork non-membrane-bounded organelle nuclear lumen cytoplasm
C [auth 4]	DNA replication licensing factor MCM4	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity adenyl ribonucleotide binding nucleotide binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides ATP-dependent activity, acting on DNA DNA helicase activity catalytic activity, acting on DNA single-stranded DNA helicase activity single-stranded DNA binding	DNA-templated DNA replication nuclear DNA replication cell cycle DNA replication primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process cellular process macromolecule metabolic process cell cycle DNA-templated DNA replication nuclear DNA replication cell cycle DNA replication primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process cellular process macromolecule metabolic process cell cycle cell cycle process DNA replication initiation sexual reproduction reproductive process meiotic cell cycle meiotic cell cycle process premeiotic DNA replication pre-replicative complex assembly cellular component organization cellular component biogenesis protein-DNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis pre-replicative complex assembly involved in nuclear cell cycle DNA replication protein-containing complex organization pre-replicative complex assembly involved in cell cycle DNA replication protein-DNA complex assembly cellular response to stimulus double-strand break repair response to stimulus DNA recombination double-strand break repair via break-induced replication cellular response to stress DNA damage response response to stress recombinational repair double-strand break repair via homologous recombination DNA repair DNA strand elongation DNA strand elongation involved in DNA replication mitotic DNA replication cell cycle DNA replication initiation mitotic DNA replication initiation mitotic cell cycle nuclear cell cycle DNA replication initiation mitotic cell cycle process DNA duplex unwinding DNA geometric change chromosome organization DNA conformation change DNA unwinding involved in DNA replication organelle organization	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle intracellular non-membrane-bounded organelle CMG complex nuclear lumen non-membrane-bounded organelle MCM core complex replication fork protection complex nuclear replication fork replication fork cytoplasm MCM complex pre-replicative complex nuclear pre-replicative complex
D [auth 5]	DNA helicase	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding protein-containing complex binding chromatin binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding protein-containing complex binding chromatin binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity ATP-dependent activity, acting on DNA DNA helicase activity catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid single-stranded DNA helicase activity helicase activity 3'-5' DNA helicase activity single-stranded DNA binding	DNA-templated DNA replication nuclear DNA replication cell cycle DNA replication primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process cellular process macromolecule metabolic process cell cycle DNA-templated DNA replication nuclear DNA replication cell cycle DNA replication primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process cellular process macromolecule metabolic process cell cycle cell cycle process DNA replication initiation sexual reproduction reproductive process meiotic cell cycle meiotic cell cycle process premeiotic DNA replication pre-replicative complex assembly cellular component organization cellular component biogenesis protein-DNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis pre-replicative complex assembly involved in nuclear cell cycle DNA replication protein-containing complex organization pre-replicative complex assembly involved in cell cycle DNA replication protein-DNA complex assembly regulation of DNA-templated DNA replication initiation regulation of biological process biological regulation regulation of macromolecule metabolic process regulation of primary metabolic process regulation of DNA-templated DNA replication regulation of nucleobase-containing compound metabolic process regulation of metabolic process regulation of DNA replication regulation of DNA metabolic process cellular response to stimulus double-strand break repair response to stimulus DNA recombination double-strand break repair via break-induced replication cellular response to stress DNA damage response response to stress recombinational repair double-strand break repair via homologous recombination DNA repair subtelomeric heterochromatin formation regulation of cellular process cellular biosynthetic process negative regulation of biological process telomere organization negative regulation of cellular metabolic process chromatin organization organic substance biosynthetic process negative regulation of cellular process chromatin remodeling negative regulation of macromolecule metabolic process regulation of biosynthetic process heterochromatin formation epigenetic regulation of gene expression cellular metabolic process negative regulation of metabolic process chromosome organization regulation of cellular metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression organelle organization negative regulation of gene expression constitutive heterochromatin formation biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process DNA duplex unwinding DNA geometric change DNA conformation change DNA unwinding involved in DNA replication	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle intracellular non-membrane-bounded organelle CMG complex nuclear lumen non-membrane-bounded organelle replication fork protection complex nuclear replication fork replication fork cytoplasm MCM complex pre-replicative complex nuclear pre-replicative complex chromosome, telomeric region chromosomal region
E [auth 6]	DNA replication licensing factor MCM6	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding ATP-dependent activity, acting on DNA DNA helicase activity catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid single-stranded 3'-5' DNA helicase activity single-stranded DNA helicase activity helicase activity catalytic activity 3'-5' DNA helicase activity ATP-dependent activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides single-stranded DNA binding	DNA-templated DNA replication DNA replication initiation primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process macromolecule metabolic process sexual reproduction reproductive process meiotic cell cycle DNA-templated DNA replication DNA replication initiation primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process macromolecule metabolic process sexual reproduction reproductive process meiotic cell cycle nuclear DNA replication cell cycle DNA replication meiotic cell cycle process premeiotic DNA replication cellular process cell cycle cell cycle process pre-replicative complex assembly cellular component organization cellular component biogenesis protein-DNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis pre-replicative complex assembly involved in nuclear cell cycle DNA replication protein-containing complex organization pre-replicative complex assembly involved in cell cycle DNA replication protein-DNA complex assembly cellular response to stimulus double-strand break repair response to stimulus DNA recombination double-strand break repair via break-induced replication cellular response to stress DNA damage response response to stress recombinational repair double-strand break repair via homologous recombination DNA repair mitotic DNA replication mitotic cell cycle mitotic cell cycle process DNA strand elongation DNA strand elongation involved in DNA replication DNA duplex unwinding DNA geometric change chromosome organization DNA conformation change DNA unwinding involved in DNA replication organelle organization	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle intracellular non-membrane-bounded organelle CMG complex nuclear lumen non-membrane-bounded organelle MCM core complex replication fork protection complex nuclear replication fork replication fork cytoplasm MCM complex pre-replicative complex nuclear pre-replicative complex
F [auth 7]	DNA replication licensing factor MCM7	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding protein-containing complex binding MCM complex binding chromatin binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding protein-containing complex binding MCM complex binding chromatin binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity ATP-dependent activity, acting on DNA DNA helicase activity catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid single-stranded DNA helicase activity helicase activity single-stranded DNA binding	DNA-templated DNA replication nuclear DNA replication cell cycle DNA replication primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process cellular process macromolecule metabolic process cell cycle DNA-templated DNA replication nuclear DNA replication cell cycle DNA replication primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process cellular process macromolecule metabolic process cell cycle cell cycle process DNA replication initiation sexual reproduction reproductive process meiotic cell cycle meiotic cell cycle process premeiotic DNA replication pre-replicative complex assembly cellular component organization cellular component biogenesis protein-DNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis pre-replicative complex assembly involved in nuclear cell cycle DNA replication protein-containing complex organization pre-replicative complex assembly involved in cell cycle DNA replication protein-DNA complex assembly regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process chromatin organization organic substance biosynthetic process negative regulation of cellular process chromatin remodeling negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process heterochromatin formation epigenetic regulation of gene expression cellular metabolic process negative regulation of metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression constitutive heterochromatin formation biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process silent mating-type cassette heterochromatin formation negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process regulation of metabolic process cellular response to stimulus double-strand break repair response to stimulus DNA recombination double-strand break repair via break-induced replication cellular response to stress DNA damage response response to stress recombinational repair double-strand break repair via homologous recombination DNA repair DNA strand elongation DNA strand elongation involved in DNA replication subtelomeric heterochromatin formation telomere organization chromosome organization organelle organization DNA duplex unwinding DNA geometric change DNA conformation change DNA unwinding involved in DNA replication	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle intracellular non-membrane-bounded organelle CMG complex nuclear lumen non-membrane-bounded organelle MCM core complex replication fork protection complex nuclear replication fork replication fork cytoplasm MCM complex pre-replicative complex nuclear pre-replicative complex chromosome, telomeric region chromosomal region
G [auth A]	DNA replication complex GINS protein PSF1	-	nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA-templated DNA replication DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process mitotic DNA replication DNA strand elongation involved in mitotic DNA replication nuclear DNA replication cell cycle DNA replication nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA-templated DNA replication DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process mitotic DNA replication DNA strand elongation involved in mitotic DNA replication nuclear DNA replication cell cycle DNA replication mitotic cell cycle DNA strand elongation DNA strand elongation involved in cell cycle DNA replication cell cycle cell cycle process DNA strand elongation involved in nuclear cell cycle DNA replication mitotic cell cycle process cellular process DNA strand elongation involved in DNA replication DNA duplex unwinding DNA geometric change chromosome organization DNA conformation change DNA unwinding involved in DNA replication cellular component organization organelle organization cellular component organization or biogenesis cellular response to stimulus double-strand break repair response to stimulus DNA recombination double-strand break repair via break-induced replication cellular response to stress DNA damage response response to stress recombinational repair double-strand break repair via homologous recombination DNA repair	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle intracellular non-membrane-bounded organelle CMG complex nuclear lumen non-membrane-bounded organelle GINS complex replication fork protection complex nuclear replication fork replication fork
H [auth B]	DNA replication complex GINS protein PSF2	-	DNA duplex unwinding DNA-templated DNA replication DNA geometric change chromosome organization primary metabolic process DNA conformation change DNA metabolic process nucleic acid metabolic process DNA unwinding involved in DNA replication cellular component organization nucleobase-containing compound metabolic process organic cyclic compound metabolic process organelle organization DNA replication organic substance metabolic process DNA duplex unwinding DNA-templated DNA replication DNA geometric change chromosome organization primary metabolic process DNA conformation change DNA metabolic process nucleic acid metabolic process DNA unwinding involved in DNA replication cellular component organization nucleobase-containing compound metabolic process organic cyclic compound metabolic process organelle organization DNA replication organic substance metabolic process cellular process metabolic process cellular component organization or biogenesis macromolecule metabolic process cellular response to stimulus double-strand break repair response to stimulus DNA recombination double-strand break repair via break-induced replication cellular response to stress DNA damage response response to stress recombinational repair double-strand break repair via homologous recombination DNA repair	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle intracellular non-membrane-bounded organelle CMG complex nuclear lumen non-membrane-bounded organelle GINS complex replication fork protection complex nuclear replication fork replication fork
I [auth C]	DNA replication complex GINS protein PSF3	-	nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA-templated DNA replication DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process mitotic DNA replication DNA replication initiation cell cycle DNA replication initiation nuclear DNA replication nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA-templated DNA replication DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process mitotic DNA replication DNA replication initiation cell cycle DNA replication initiation nuclear DNA replication cell cycle DNA replication mitotic DNA replication initiation mitotic cell cycle nuclear cell cycle DNA replication initiation mitotic cell cycle process cellular process cell cycle cell cycle process DNA duplex unwinding DNA geometric change chromosome organization DNA conformation change DNA unwinding involved in DNA replication cellular component organization organelle organization cellular component organization or biogenesis cellular response to stimulus double-strand break repair response to stimulus DNA recombination double-strand break repair via break-induced replication cellular response to stress DNA damage response response to stress recombinational repair double-strand break repair via homologous recombination DNA repair	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle intracellular non-membrane-bounded organelle CMG complex nuclear lumen non-membrane-bounded organelle GINS complex replication fork protection complex nuclear replication fork replication fork

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth 2]	IPR031327	Mini-chromosome maintenance protein	Family
A [auth 2]	IPR018525	Mini-chromosome maintenance, conserved site	Conserved Site
A [auth 2]	IPR001208	MCM domain	Domain
A [auth 2]	IPR041562	MCM, AAA-lid domain	Domain
A [auth 2]	IPR008045	DNA replication licensing factor Mcm2	Family
A [auth 2]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A [auth 2]	IPR027925	MCM, N-terminal domain	Domain
A [auth 2]	IPR033762	MCM OB domain	Domain
A [auth 2]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
J [auth D]	IPR008591	GINS complex subunit Sld5	Family
J [auth D]	IPR038749	GINS complex protein Sld5, alpha-helical domain	Domain
J [auth D]	IPR036224	GINS, helical bundle-like domain superfamily	Homologous Superfamily
J [auth D]	IPR021151	GINS subunit, domain A	Domain
J [auth D]	IPR031633	DNA replication complex GINS protein SLD5, C-terminal	Domain
K [auth E]	IPR003874	CDC45 family	Family
L [auth F], M [auth G], N [auth H]	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
L [auth F], M [auth G], N [auth H]	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
L [auth F], M [auth G], N [auth H]	IPR022100	Minichromosome loss protein Mcl1, middle region	Domain
L [auth F], M [auth G], N [auth H]	IPR048591	DNA polymerase alpha-binding protein Ctf4-like, C-terminal domain	Domain
Q [auth K]	IPR016073	SKP1 component, POZ domain	Domain
Q [auth K]	IPR001232	S-phase kinase-associated protein 1-like	Family
Q [auth K]	IPR036296	SKP1-like, dimerisation domain superfamily	Homologous Superfamily
Q [auth K]	IPR016072	SKP1 component, dimerisation	Domain
Q [auth K]	IPR011333	SKP1/BTB/POZ domain superfamily	Homologous Superfamily
Q [auth K]	IPR016897	S-phase kinase-associated protein 1	Family
R [auth L]	IPR036047	F-box-like domain superfamily	Homologous Superfamily
R [auth L]	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
R [auth L]	IPR001611	Leucine-rich repeat	Repeat
R [auth L]	IPR001810	F-box domain	Domain
R [auth L]	IPR032675	Leucine-rich repeat domain superfamily	Homologous Superfamily
R [auth L]	IPR006553	Leucine-rich repeat, cysteine-containing subtype	Repeat
S [auth Q]	IPR036397	Ribonuclease H superfamily	Homologous Superfamily
S [auth Q]	IPR006134	DNA-directed DNA polymerase, family B, multifunctional domain	Domain
S [auth Q]	IPR012337	Ribonuclease H-like superfamily	Homologous Superfamily
S [auth Q]	IPR023211	DNA polymerase, palm domain superfamily	Homologous Superfamily
S [auth Q]	IPR006172	DNA-directed DNA polymerase, family B	Family
S [auth Q]	IPR029703	DNA polymerase epsilon catalytic subunit	Family
S [auth Q]	IPR043502	DNA/RNA polymerase superfamily	Homologous Superfamily
S [auth Q]	IPR013697	DNA polymerase epsilon, catalytic subunit A, C-terminal	Domain
S [auth Q]	IPR006133	DNA-directed DNA polymerase, family B, exonuclease domain	Domain
S [auth Q]	IPR042087	DNA polymerase family B, thumb domain	Homologous Superfamily
T [auth R]	IPR016266	DNA polymerase epsilon, subunit B	Family
T [auth R]	IPR007185	DNA polymerase alpha/delta/epsilon, subunit B	Domain
U [auth X]	IPR044998	Timeless	Family
U [auth X]	IPR006906	Timeless, N-terminal	Domain
B [auth 3]	IPR031327	Mini-chromosome maintenance protein	Family
B [auth 3]	IPR018525	Mini-chromosome maintenance, conserved site	Conserved Site
B [auth 3]	IPR003593	AAA+ ATPase domain	Domain
B [auth 3]	IPR001208	MCM domain	Domain
B [auth 3]	IPR041562	MCM, AAA-lid domain	Domain
B [auth 3]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
B [auth 3]	IPR027925	MCM, N-terminal domain	Domain
B [auth 3]	IPR008046	DNA replication licensing factor Mcm3	Family
B [auth 3]	IPR033762	MCM OB domain	Domain
B [auth 3]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
V [auth Y]	IPR012923	Chromosome segregation in meiosis protein 3	Domain
V [auth Y]	IPR040038	TIPIN/Csm3/Swi3	Family
C [auth 4]	IPR031327	Mini-chromosome maintenance protein	Family
C [auth 4]	IPR018525	Mini-chromosome maintenance, conserved site	Conserved Site
C [auth 4]	IPR001208	MCM domain	Domain
C [auth 4]	IPR041562	MCM, AAA-lid domain	Domain
C [auth 4]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
C [auth 4]	IPR027925	MCM, N-terminal domain	Domain
C [auth 4]	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
C [auth 4]	IPR008047	Mini-chromosome maintenance complex protein 4	Family
C [auth 4]	IPR033762	MCM OB domain	Domain
C [auth 4]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
D [auth 5]	IPR031327	Mini-chromosome maintenance protein	Family
D [auth 5]	IPR018525	Mini-chromosome maintenance, conserved site	Conserved Site
D [auth 5]	IPR001208	MCM domain	Domain
D [auth 5]	IPR041562	MCM, AAA-lid domain	Domain
D [auth 5]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
D [auth 5]	IPR027925	MCM, N-terminal domain	Domain
D [auth 5]	IPR033762	MCM OB domain	Domain
D [auth 5]	IPR008048	DNA replication licensing factor Mcm5	Family
D [auth 5]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
E [auth 6]	IPR008049	DNA replication licensing factor Mcm6	Family
E [auth 6]	IPR041024	Mcm6, C-terminal winged-helix domain	Domain
E [auth 6]	IPR031327	Mini-chromosome maintenance protein	Family
E [auth 6]	IPR018525	Mini-chromosome maintenance, conserved site	Conserved Site
E [auth 6]	IPR001208	MCM domain	Domain
E [auth 6]	IPR041562	MCM, AAA-lid domain	Domain
E [auth 6]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
E [auth 6]	IPR027925	MCM, N-terminal domain	Domain
E [auth 6]	IPR033762	MCM OB domain	Domain
E [auth 6]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
F [auth 7]	IPR031327	Mini-chromosome maintenance protein	Family
F [auth 7]	IPR008050	DNA replication licensing factor Mcm7	Family
F [auth 7]	IPR018525	Mini-chromosome maintenance, conserved site	Conserved Site
F [auth 7]	IPR003593	AAA+ ATPase domain	Domain
F [auth 7]	IPR001208	MCM domain	Domain
F [auth 7]	IPR041562	MCM, AAA-lid domain	Domain
F [auth 7]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
F [auth 7]	IPR027925	MCM, N-terminal domain	Domain
F [auth 7]	IPR033762	MCM OB domain	Domain
F [auth 7]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
G [auth A]	IPR005339	GINS complex, subunit Psf1	Family
G [auth A]	IPR036224	GINS, helical bundle-like domain superfamily	Homologous Superfamily
G [auth A]	IPR021151	GINS subunit, domain A	Domain
H [auth B]	IPR007257	DNA replication complex GINS protein Psf2	Family
H [auth B]	IPR021151	GINS subunit, domain A	Domain
H [auth B]	IPR036224	GINS, helical bundle-like domain superfamily	Homologous Superfamily
I [auth C]	IPR036224	GINS, helical bundle-like domain superfamily	Homologous Superfamily
I [auth C]	IPR021151	GINS subunit, domain A	Domain
I [auth C]	IPR010492	GINS complex, subunit Psf3	Family
I [auth C]	IPR038437	GINS complex, subunit Psf3 superfamily	Homologous Superfamily