7NWU

Co-crystal structure of UPF3B-RRM-NOPS-L with UPF2-MIF4GIII

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	RNA-binding domain RBD	8035186	3000110	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	RNA-binding domain RBD	8035186	3000110	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	RNA-binding domain RBD	8035186	3000110	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	RNA-binding domain RBD	8035186	3000110	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	ARM repeat-like	8035191	3000116	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	ARM repeat-like	8035191	3000116	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	ARM repeat-like	8035191	3000116	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	ARM repeat-like	8035191	3000116	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	PF03467	e7nwuC1	A: a+b two layers	X: Alpha-beta plaits	H: RNA-binding domain, RBD (From Topology)	T: RNA-binding domain, RBD	F: PF03467	ECOD (1.6)
E	PF03467	e7nwuE1	A: a+b two layers	X: Alpha-beta plaits	H: RNA-binding domain, RBD (From Topology)	T: RNA-binding domain, RBD	F: PF03467	ECOD (1.6)
B	PF02854	e7nwuB1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF02854	ECOD (1.6)
D	PF02854	e7nwuD1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF02854	ECOD (1.6)
F	PF02854	e7nwuF1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF02854	ECOD (1.6)
H	PF02854	e7nwuH1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF02854	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C, E, G	PF03467	Smg-4/UPF3 family (Smg4_UPF3)	Smg-4/UPF3 family	-	Family
B, D, F, H	PF02854	MIF4G domain (MIF4G)	MIF4G domain	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C, E, G	Regulator of nonsense transcripts 3B	RNA binding binding organic cyclic compound binding nucleic acid binding mRNA binding	regulation of cellular process cellular biosynthetic process positive regulation of protein metabolic process organonitrogen compound biosynthetic process positive regulation of biological process positive regulation of translation positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process post-transcriptional regulation of gene expression positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process organic substance biosynthetic process regulation of cellular process cellular biosynthetic process positive regulation of protein metabolic process organonitrogen compound biosynthetic process positive regulation of biological process positive regulation of translation positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process post-transcriptional regulation of gene expression positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process protein metabolic process positive regulation of cellular process regulation of biosynthetic process regulation of biological process organonitrogen compound metabolic process cellular metabolic process regulation of protein metabolic process biological regulation regulation of cellular metabolic process primary metabolic process regulation of macromolecule metabolic process gene expression translation macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of translation regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process developmental process multicellular organism development multicellular organismal process head development central nervous system development anatomical structure development animal organ development brain development nervous system development system development cellular developmental process regulation of developmental process regulation of cell differentiation positive regulation of neuron differentiation positive regulation of developmental process neurogenesis neuron differentiation positive regulation of cell differentiation cell differentiation generation of neurons regulation of neuron differentiation RNA transport nitrogen compound transport transport organic substance transport nucleic acid transport mRNA transport establishment of localization localization establishment of RNA localization macromolecule localization RNA localization nucleobase-containing compound transport catabolic process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay negative regulation of biological process RNA metabolic process negative regulation of cellular metabolic process macromolecule catabolic process nucleobase-containing compound metabolic process negative regulation of cellular process RNA catabolic process negative regulation of macromolecule metabolic process mRNA catabolic process nuclear-transcribed mRNA catabolic process negative regulation of metabolic process mRNA metabolic process negative regulation of cellular biosynthetic process nucleic acid metabolic process organic cyclic compound catabolic process nucleobase-containing compound catabolic process organic cyclic compound metabolic process negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process nucleic acid catabolic process organic substance catabolic process positive regulation of mRNA cis splicing, via spliceosome regulation of mRNA splicing, via spliceosome mRNA processing regulation of mRNA cis splicing, via spliceosome regulation of RNA metabolic process RNA processing regulation of nucleobase-containing compound metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of mRNA metabolic process positive regulation of RNA metabolic process mRNA cis splicing, via spliceosome positive regulation of mRNA processing positive regulation of mRNA splicing, via spliceosome regulation of mRNA processing RNA splicing regulation of RNA splicing RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile regulation of mRNA metabolic process positive regulation of RNA splicing plasma membrane bounded cell projection organization cell projection organization cell development neuron projection development cellular component organization neuron development cellular component organization or biogenesis	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle centrosome microtubule organizing center cytoskeleton centriolar satellite microtubule cytoskeleton cytoplasm cytosol protein-containing complex exon-exon junction complex nuclear protein-containing complex somatodendritic compartment cell body neuronal cell body nucleoplasm
B, D, F, H	Regulator of nonsense transcripts 2	RNA binding binding organic cyclic compound binding nucleic acid binding sequence-specific DNA binding DNA binding telomeric DNA binding	developmental process multicellular organism development multicellular organismal process hepaticobiliary system development gland development animal organ development anatomical structure development liver development system development cellular localization nitrogen compound transport nucleocytoplasmic transport transport cellular biosynthetic process developmental process multicellular organism development multicellular organismal process hepaticobiliary system development gland development animal organ development anatomical structure development liver development system development cellular localization nitrogen compound transport nucleocytoplasmic transport transport cellular biosynthetic process nuclear transport mRNA transport localization organic substance metabolic process mRNA export from nucleus establishment of localization in cell organic substance biosynthetic process RNA localization nuclear export nucleobase-containing compound transport RNA transport organic substance transport cellular metabolic process nucleic acid transport intracellular transport gene expression establishment of localization macromolecule biosynthetic process RNA export from nucleus establishment of RNA localization biosynthetic process macromolecule localization cellular process metabolic process macromolecule metabolic process animal organ regeneration regeneration regulation of cellular process catabolic process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay negative regulation of biological process RNA metabolic process negative regulation of cellular metabolic process macromolecule catabolic process nucleobase-containing compound metabolic process negative regulation of cellular process RNA catabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process mRNA catabolic process nuclear-transcribed mRNA catabolic process regulation of biological process negative regulation of metabolic process biological regulation regulation of cellular metabolic process primary metabolic process regulation of macromolecule metabolic process mRNA metabolic process negative regulation of cellular biosynthetic process nucleic acid metabolic process organic cyclic compound catabolic process nucleobase-containing compound catabolic process regulation of cellular biosynthetic process regulation of gene expression organic cyclic compound metabolic process negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process nucleic acid catabolic process regulation of macromolecule biosynthetic process regulation of metabolic process organic substance catabolic process	intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle cytoplasmic ribonucleoprotein granule cellular anatomical entity cytoplasm supramolecular complex non-membrane-bounded organelle ribonucleoprotein granule cytosol perinuclear region of cytoplasm membrane-bounded organelle protein-containing complex intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle cytoplasmic ribonucleoprotein granule cellular anatomical entity cytoplasm supramolecular complex non-membrane-bounded organelle ribonucleoprotein granule cytosol perinuclear region of cytoplasm membrane-bounded organelle protein-containing complex nucleus exon-exon junction complex nuclear protein-containing complex intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C, E, G	IPR034979	UPF3B, RNA recognition motif-like domain	Domain
A, C, E, G	IPR039722	Nonsense-mediated mRNA decay protein 3	Family
A, C, E, G	IPR005120	UPF3 domain	Domain
A, C, E, G	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily	Homologous Superfamily
A, C, E, G	IPR035979	RNA-binding domain superfamily	Homologous Superfamily
B, D, F, H	IPR016024	Armadillo-type fold	Homologous Superfamily
B, D, F, H	IPR039762	Nonsense-mediated mRNA decay protein Nmd2/UPF2	Family
B, D, F, H	IPR007193	Up-frameshift suppressor 2, C-terminal	Domain
B, D, F, H	IPR003890	MIF4G-like, type 3	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, C, E, G	Pharos: Q9BZI7	syndromic X-linked intellectual disability 14 FG syndrome autism, susceptibility to, X-linked 2 intellectual disability adrenal cortex carcinoma lung cancer Mental Retardation, X-Linked 1 malignant mesothelioma Pick disease thoracic aortic aneurysm dermatomyositis progressive supranuclear palsy X-linked intellectual disability with marfanoid habitus

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.