Annotations: 7M5A

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00452	e7m5aA1	A: alpha arrays	X: Toxins' membrane translocation domains	H: Bcl-2 inhibitors of programmed cell death (From Topology)	T: Bcl-2 inhibitors of programmed cell death	F: PF00452	ECOD (1.6)
B	PF06393	e7m5aB1	A: alpha arrays	X: Toxins' membrane translocation domains	H: Bcl-2 inhibitors of programmed cell death (From Topology)	T: Bcl-2 inhibitors of programmed cell death	F: PF06393	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00452	Apoptosis regulator proteins, Bcl-2 family (Bcl-2)	Apoptosis regulator proteins, Bcl-2 family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Bcl-2 homologous antagonist/killer	protein binding binding heat shock protein binding BH domain binding protein domain specific binding protein-folding chaperone binding wide pore channel activity passive transmembrane transporter activity channel activity porin activity transporter activity transmembrane transporter activity protein-containing complex binding cation binding protein binding binding heat shock protein binding BH domain binding protein domain specific binding protein-folding chaperone binding wide pore channel activity passive transmembrane transporter activity channel activity porin activity transporter activity transmembrane transporter activity protein-containing complex binding cation binding ion binding metal ion binding small molecule binding identical protein binding protein heterodimerization activity protein dimerization activity transmembrane transporter binding protein homodimerization activity	response to stimulus response to chemical response to xenobiotic stimulus developmental process camera-type eye morphogenesis multicellular organismal process sensory organ development eye development post-embryonic camera-type eye development animal organ development visual system development post-embryonic camera-type eye morphogenesis eye morphogenesis multicellular organism development response to stimulus response to chemical response to xenobiotic stimulus developmental process camera-type eye morphogenesis multicellular organismal process sensory organ development eye development post-embryonic camera-type eye development animal organ development visual system development post-embryonic camera-type eye morphogenesis eye morphogenesis multicellular organism development anatomical structure morphogenesis post-embryonic eye morphogenesis sensory organ morphogenesis anatomical structure development camera-type eye development animal organ morphogenesis post-embryonic development sensory system development system development inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process calcium ion homeostasis endoplasmic reticulum calcium ion homeostasis cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis organelle fusion cellular component organization organelle organization cellular process mitochondrial fusion cellular component organization or biogenesis mitochondrion organization activation of cysteine-type endopeptidase activity regulation of catalytic activity cellular biosynthetic process positive regulation of protein metabolic process positive regulation of peptidase activity positive regulation of biological process protein maturation regulation of primary metabolic process positive regulation of molecular function positive regulation of metabolic process organic substance metabolic process regulation of proteolysis proteolysis regulation of endopeptidase activity organic substance biosynthetic process positive regulation of macromolecule metabolic process protein metabolic process zymogen activation regulation of cysteine-type endopeptidase activity regulation of biological process organonitrogen compound metabolic process cellular metabolic process regulation of protein metabolic process regulation of peptidase activity biological regulation positive regulation of catalytic activity primary metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of molecular function positive regulation of hydrolase activity biosynthetic process positive regulation of cysteine-type endopeptidase activity regulation of hydrolase activity positive regulation of endopeptidase activity positive regulation of proteolysis protein processing metabolic process macromolecule metabolic process regulation of metabolic process cellular response to stimulus positive regulation of organelle organization regulation of cellular process regulation of cellular component organization positive regulation of cellular component organization signaling apoptotic mitochondrial changes regulation of release of cytochrome c from mitochondria cell communication positive regulation of release of cytochrome c from mitochondria signal transduction positive regulation of cellular process cell death regulation of organelle organization apoptotic signaling pathway release of cytochrome c from mitochondria regulation of mitochondrion organization apoptotic process programmed cell death protein-containing complex organization positive regulation of cellular component biogenesis regulation of cellular component biogenesis cellular component biogenesis positive regulation of protein-containing complex assembly regulation of protein-containing complex assembly cellular component assembly protein-containing complex assembly response to mycotoxin response to toxic substance positive regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death positive regulation of apoptotic process biological process involved in interspecies interaction between organisms response to other organism response to external stimulus response to fungus response to external biotic stimulus response to biotic stimulus B cell homeostasis multicellular organismal-level homeostasis leukocyte homeostasis immune system process homeostasis of number of cells lymphocyte homeostasis regulation of localization negative regulation of biological process regulation of signal transduction localization negative regulation of apoptotic signaling pathway regulation of biological quality positive regulation of membrane permeability negative regulation of cellular component organization negative regulation of programmed cell death establishment of localization negative regulation of apoptotic process regulation of response to stimulus regulation of membrane permeability negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway regulation of mitochondrial membrane permeability involved in apoptotic process regulation of apoptotic signaling pathway negative regulation of mitochondrial membrane permeability transport negative regulation of signaling mitochondrial outer membrane permeabilization involved in programmed cell death negative regulation of cell communication mitochondrial membrane organization positive regulation of mitochondrial membrane permeability involved in apoptotic process negative regulation of cellular process positive regulation of mitochondrial membrane permeability regulation of mitochondrial membrane permeability mitochondrial transport membrane organization regulation of signaling regulation of transport negative regulation of response to stimulus negative regulation of signal transduction negative regulation of organelle organization regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway regulation of cell communication negative regulation of membrane permeability mitochondrial outer membrane permeabilization limb development appendage development appendage morphogenesis limb morphogenesis fibroblast apoptotic process signal transduction in absence of ligand cell surface receptor signaling pathway extrinsic apoptotic signaling pathway extrinsic apoptotic signaling pathway in absence of ligand positive regulation of IRE1-mediated unfolded protein response positive regulation of cell communication response to organic substance positive regulation of signal transduction regulation of cellular response to stress endoplasmic reticulum unfolded protein response regulation of response to endoplasmic reticulum stress positive regulation of response to stimulus regulation of endoplasmic reticulum unfolded protein response positive regulation of response to endoplasmic reticulum stress cellular response to stress response to stress regulation of response to stress positive regulation of endoplasmic reticulum unfolded protein response cellular response to organic substance response to endoplasmic reticulum stress regulation of IRE1-mediated unfolded protein response cellular response to topologically incorrect protein cellular response to unfolded protein response to unfolded protein cellular response to chemical stimulus response to topologically incorrect protein IRE1-mediated unfolded protein response positive regulation of signaling negative regulation of release of cytochrome c from mitochondria regulation of calcium ion transport positive regulation of cation transmembrane transport positive regulation of calcium ion transport cellular localization regulation of calcium ion transport into cytosol monoatomic ion transmembrane transport regulation of monoatomic ion transmembrane transport calcium ion transport metal ion transport monoatomic cation transmembrane transport regulation of calcium ion transmembrane transport positive regulation of monoatomic ion transport positive regulation of calcium ion transmembrane transport positive regulation of transmembrane transport monoatomic ion transport positive regulation of monoatomic ion transmembrane transport monoatomic cation transport regulation of metal ion transport calcium ion transmembrane import into cytosol regulation of monoatomic ion transport positive regulation of cytosolic calcium ion concentration inorganic ion transmembrane transport inorganic cation transmembrane transport transmembrane transport positive regulation of calcium ion transport into cytosol regulation of transmembrane transport positive regulation of transport regulation of cellular localization regulation of monoatomic cation transmembrane transport calcium ion transmembrane transport calcium ion transport into cytosol cellular developmental process hemopoiesis B cell activation cell activation cell development B cell negative selection mononuclear cell differentiation lymphocyte differentiation lymphocyte activation leukocyte activation B cell differentiation cell differentiation B cell selection leukocyte differentiation lymphocyte apoptotic process thymocyte apoptotic process leukocyte apoptotic process T cell apoptotic process response to hydrogen peroxide response to oxidative stress response to oxygen-containing compound response to reactive oxygen species response to inorganic substance establishment or maintenance of transmembrane electrochemical gradient genitalia development reproductive system development reproductive process female genitalia development sex differentiation female sex differentiation developmental process involved in reproduction vagina development reproductive structure development intracellular signal transduction intrinsic apoptotic signaling pathway regulation of mitochondrial membrane potential regulation of membrane potential B cell apoptotic process negative regulation of endoplasmic reticulum calcium ion concentration regulation of protein modification process regulation of protein phosphorylation negative regulation of phosphate metabolic process regulation of peptidyl-serine phosphorylation negative regulation of cellular metabolic process peptidyl-serine modification peptidyl-serine phosphorylation regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of protein modification process peptidyl-amino acid modification protein modification process phosphorus metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process negative regulation of peptidyl-serine phosphorylation protein phosphorylation phosphorylation negative regulation of metabolic process regulation of cellular metabolic process negative regulation of protein phosphorylation macromolecule modification negative regulation of phosphorus metabolic process regulation of phosphorylation regulation of phosphorus metabolic process negative regulation of phosphorylation establishment of localization in cell response to alcohol response to ethanol pancreas development endocrine system development endocrine pancreas development myeloid cell homeostasis DNA damage response intrinsic apoptotic signaling pathway in response to DNA damage blood vessel remodeling tissue remodeling cell population proliferation epithelial cell proliferation response to mechanical stimulus response to abiotic stimulus cellular response to mechanical stimulus cellular response to abiotic stimulus cellular response to external stimulus cellular response to environmental stimulus response to light stimulus cellular response to radiation response to UV cellular response to light stimulus response to radiation cellular response to UV negative regulation of cell population proliferation regulation of cell population proliferation intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress response to ionizing radiation response to gamma radiation apoptotic process involved in morphogenesis blood vessel morphogenesis tube development vasculature development circulatory system development apoptotic process involved in development tube morphogenesis apoptotic process involved in blood vessel morphogenesis blood vessel development animal organ regeneration regeneration cell cycle regulation of cell cycle regulation of biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway response to organic cyclic compound response to UV-C	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle mitochondrial membrane mitochondrion membrane organelle outer membrane intracellular membrane-bounded organelle intracellular organelle organelle envelope bounding membrane of organelle organelle intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle mitochondrial membrane mitochondrion membrane organelle outer membrane intracellular membrane-bounded organelle intracellular organelle organelle envelope bounding membrane of organelle organelle mitochondrial envelope mitochondrial outer membrane outer membrane organelle membrane protein-containing complex BAK complex Bcl-2 family protein complex pore complex membrane protein complex endoplasmic reticulum endomembrane system
B	BH3-interacting domain death agonist p15	enzyme regulator activity molecular function regulator activity cysteine-type endopeptidase regulator activity involved in apoptotic process protein binding binding signaling receptor binding cytokine receptor binding tumor necrosis factor receptor superfamily binding death receptor binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding enzyme binding	cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis protein localization establishment of protein localization cellular localization protein targeting establishment of localization localization establishment of protein localization to organelle cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis protein localization establishment of protein localization cellular localization protein targeting establishment of localization localization establishment of protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to organelle protein localization to mitochondrion protein targeting to mitochondrion establishment of protein localization to mitochondrion organelle organization apoptotic mitochondrial changes apoptotic process cell death programmed cell death mitochondrion organization cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation intracellular signal transduction cell communication cellular response to stress DNA damage response response to stress signal transduction in response to DNA damage signal transduction multicellular organismal process regulation of leukocyte activation regulation of cell activation lymphocyte activation leukocyte proliferation leukocyte activation T cell activation lymphocyte proliferation regulation of multicellular organismal process regulation of immune system process T cell proliferation regulation of lymphocyte proliferation regulation of leukocyte proliferation cell population proliferation cell activation regulation of T cell activation regulation of T cell proliferation regulation of cell population proliferation mononuclear cell proliferation immune system process regulation of mononuclear cell proliferation regulation of lymphocyte activation positive regulation of organelle organization regulation of cellular component organization positive regulation of cellular component organization positive regulation of biological process regulation of release of cytochrome c from mitochondria positive regulation of release of cytochrome c from mitochondria positive regulation of cellular process regulation of organelle organization apoptotic signaling pathway release of cytochrome c from mitochondria regulation of mitochondrion organization positive regulation of cellular component biogenesis regulation of cellular component biogenesis positive regulation of protein-containing complex assembly regulation of protein-containing complex assembly positive regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death positive regulation of apoptotic process positive regulation of cell communication positive regulation of signal transduction regulation of signal transduction extrinsic apoptotic signaling pathway positive regulation of apoptotic signaling pathway positive regulation of response to stimulus regulation of signaling cell surface receptor signaling pathway positive regulation of extrinsic apoptotic signaling pathway regulation of extrinsic apoptotic signaling pathway regulation of response to stimulus regulation of cell communication regulation of apoptotic signaling pathway positive regulation of signaling regulation of mitochondrial membrane potential positive regulation of mitochondrial membrane potential regulation of biological quality positive regulation of membrane potential regulation of membrane potential extrinsic apoptotic signaling pathway via death domain receptors fibroblast apoptotic process positive regulation of fibroblast apoptotic process regulation of fibroblast apoptotic process regulation of epithelial cell proliferation epithelial cell proliferation hepatocyte apoptotic process epithelial cell apoptotic process neuron apoptotic process regulation of intrinsic apoptotic signaling pathway regulation of intracellular signal transduction intrinsic apoptotic signaling pathway positive regulation of intracellular signal transduction positive regulation of intrinsic apoptotic signaling pathway aerobic respiration cellular respiration oxidative phosphorylation energy derivation by oxidation of organic compounds cellular metabolic process ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy respiratory electron transport chain metabolic process mitochondrial ATP synthesis coupled electron transport establishment of protein localization to membrane localization within membrane protein localization to membrane supramolecular fiber organization transport mitochondrial outer membrane permeabilization involved in programmed cell death mitochondrial membrane organization positive regulation of mitochondrial membrane permeability involved in apoptotic process positive regulation of mitochondrial membrane permeability positive regulation of membrane permeability regulation of mitochondrial membrane permeability mitochondrial transport membrane organization regulation of membrane permeability regulation of mitochondrial membrane permeability involved in apoptotic process mitochondrial outer membrane permeabilization negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of biological process regulation of cellular response to stress regulation of intrinsic apoptotic signaling pathway in response to DNA damage negative regulation of cell communication negative regulation of apoptotic signaling pathway regulation of response to stress negative regulation of cellular process intrinsic apoptotic signaling pathway in response to DNA damage negative regulation of response to stimulus negative regulation of programmed cell death negative regulation of signal transduction negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage negative regulation of intrinsic apoptotic signaling pathway negative regulation of apoptotic process regulation of cell cycle phase transition regulation of cell cycle process cell cycle phase transition regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition mitotic cell cycle regulation of mitotic cell cycle phase transition regulation of mitotic cell cycle regulation of G1/S transition of mitotic cell cycle mitotic cell cycle process cell cycle regulation of cell cycle G1/S transition of mitotic cell cycle cell cycle process mitotic cell cycle phase transition	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle membrane cytosol mitochondrial membrane organelle outer membrane organelle envelope bounding membrane of organelle membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle membrane cytosol mitochondrial membrane organelle outer membrane organelle envelope bounding membrane of organelle mitochondrial envelope mitochondrial outer membrane outer membrane organelle membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036834	Bcl-2-like superfamily	Homologous Superfamily
A	IPR002475	Bcl2-like	Family
A	IPR020728	Apoptosis regulator, Bcl-2, BH3 motif, conserved site	Conserved Site
A	IPR020726	Apoptosis regulator, Bcl-2, BH2 motif, conserved site	Conserved Site
A	IPR046371	Bcl-2, Bcl-2 homology region 1-3	Domain
A	IPR026298	Bcl-2 family	Family
A	IPR020717	Apoptosis regulator, Bcl-2, BH1 motif, conserved site	Conserved Site
B	IPR036834	Bcl-2-like superfamily	Homologous Superfamily
B	IPR010479	BH3-interacting domain death agonist	Family
B	IPR020728	Apoptosis regulator, Bcl-2, BH3 motif, conserved site	Conserved Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q16611	B-cell chronic lymphocytic leukemia Nerve Degeneration testicular germ cell tumor malignant colon neoplasm acute myeloid leukemia peripheral neuropathy attention deficit hyperactivity disorder, inattentive type benign colon neoplasm Graves disease ovarian cancer psoriasis autism spectrum disorder colonic neoplasm peripheral nervous system disease testicular cancer
B	Pharos: P55957	psoriasis atypical teratoid rhabdoid tumor breast carcinoma gastric cancer hepatocellular carcinoma lung cancer Malignant neoplasm of stomach oligodendroglioma schizophrenia B-cell chronic lymphocytic leukemia Crohn disease gastric carcinoma hereditary diffuse gastric adenocarcinoma malignant colon neoplasm malignant pancreatic neoplasm psoriasis atypical teratoid rhabdoid tumor breast carcinoma gastric cancer hepatocellular carcinoma lung cancer Malignant neoplasm of stomach oligodendroglioma schizophrenia B-cell chronic lymphocytic leukemia Crohn disease gastric carcinoma hereditary diffuse gastric adenocarcinoma malignant colon neoplasm malignant pancreatic neoplasm ovarian cancer tuberculosis bipolar disorder esophageal adenocarcinoma gastric neoplasm malignant mesothelioma medulloblastoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.