Annotations: 7LFF

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00225	e7lffA1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00225	ECOD (1.6)
B	PF00225	e7lffB1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00225	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00225	Kinesin motor domain (Kinesin)	Kinesin motor domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Kinesin-like protein	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cytoskeletal protein binding microtubule binding protein binding tubulin binding tubulin-dependent ATPase activity ATP-dependent activity plus-end-directed microtubule motor activity microtubule motor activity cytoskeletal motor activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity	cellular component disassembly spindle disassembly microtubule cytoskeleton organization mitotic cell cycle mitotic spindle organization cellular component organization organelle organization mitotic cell cycle process organelle disassembly mitotic spindle disassembly cellular process microtubule-based process cell cycle cellular component organization or biogenesis cellular component disassembly spindle disassembly microtubule cytoskeleton organization mitotic cell cycle mitotic spindle organization cellular component organization organelle organization mitotic cell cycle process organelle disassembly mitotic spindle disassembly cellular process microtubule-based process cell cycle cellular component organization or biogenesis cytoskeleton organization microtubule cytoskeleton organization involved in mitosis spindle organization cell cycle process establishment of organelle localization cellular localization organelle transport along microtubule transport nucleus localization intracellular transport establishment of localization localization organelle localization establishment of localization in cell nuclear migration along microtubule microtubule-based transport transport along microtubule cytoskeleton-dependent intracellular transport microtubule-based movement nuclear migration regulation of cytoskeleton organization regulation of microtubule polymerization or depolymerization regulation of cellular component organization regulation of cellular process negative regulation of biological process cellular component biogenesis regulation of protein-containing complex assembly cellular component assembly microtubule polymerization or depolymerization negative regulation of cellular process protein-containing complex assembly negative regulation of protein polymerization negative regulation of supramolecular fiber organization protein polymerization regulation of biological process negative regulation of cellular component organization negative regulation of microtubule polymerization or depolymerization protein-containing complex organization negative regulation of cytoskeleton organization biological regulation regulation of microtubule-based process negative regulation of microtubule polymerization microtubule polymerization regulation of cellular component biogenesis regulation of organelle organization negative regulation of protein-containing complex assembly negative regulation of organelle organization regulation of protein polymerization regulation of microtubule polymerization regulation of supramolecular fiber organization supramolecular fiber organization regulation of microtubule cytoskeleton organization regulation of chromosome segregation mitotic spindle elongation spindle elongation mitotic sister chromatid segregation regulation of spindle elongation regulation of cell cycle chromosome segregation mitotic nuclear division regulation of cell cycle process organelle fission chromosome organization sister chromatid segregation regulation of chromosome organization nuclear division regulation of mitotic sister chromatid segregation regulation of sister chromatid segregation regulation of mitotic spindle elongation nuclear chromosome segregation protein-containing complex disassembly microtubule depolymerization protein depolymerization plus-end specific microtubule depolymerization spindle localization establishment or maintenance of cell polarity establishment of mitotic spindle localization establishment of spindle localization establishment of spindle orientation establishment of cell polarity establishment of mitotic spindle orientation non-membrane-bounded organelle assembly organelle assembly spindle assembly mitotic spindle assembly meiotic chromosome segregation sexual reproduction reproductive process meiotic cell cycle meiotic cell cycle process meiosis II cell cycle process chromosome organization involved in meiotic cell cycle meiotic sister chromatid segregation meiotic nuclear division meiosis II	polymeric cytoskeletal fiber intracellular anatomical structure mitotic spindle spindle aster mitotic spindle astral microtubule astral microtubule spindle microtubule cellular anatomical entity cytoplasmic microtubule intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle polymeric cytoskeletal fiber intracellular anatomical structure mitotic spindle spindle aster mitotic spindle astral microtubule astral microtubule spindle microtubule cellular anatomical entity cytoplasmic microtubule intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle supramolecular fiber cytoplasm microtubule supramolecular polymer supramolecular complex microtubule cytoskeleton non-membrane-bounded organelle microtubule end microtubule plus-end protein-containing complex microtubule associated complex kinesin complex mitotic spindle midzone spindle midzone membrane-bounded organelle nucleus intracellular membrane-bounded organelle nuclear microtubule

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036961	Kinesin motor domain superfamily	Homologous Superfamily
A, B	IPR001752	Kinesin motor domain	Domain
A, B	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A, B	IPR027640	Kinesin-like protein	Family
A, B	IPR019821	Kinesin motor domain, conserved site	Conserved Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.