7K8R
Crystal structure of an anti-SARS-CoV-2 human neutralizing antibody Fab fragment, C135
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
| Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
|---|---|---|---|---|---|---|---|---|
| A [auth H] | d7k8rh_ | All beta proteins | Immunoglobulin-like beta-sandwich | Immunoglobulin | V set domains (antibody variable domain-like) | automated matches | Human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
| B [auth L] | d7k8rl2 | All beta proteins | Immunoglobulin-like beta-sandwich | Immunoglobulin | C1 set domains (antibody constant domain-like) | automated matches | Human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
| B [auth L] | d7k8rl1 | All beta proteins | Immunoglobulin-like beta-sandwich | Immunoglobulin | automated matches | automated matches | Human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
Domain Annotation: ECOD Classification ECOD Database Homepage
| Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
|---|---|---|---|---|---|---|---|---|
| A [auth H] | V-set_8 | e7k8rH1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set_8 | ECOD (1.6) |
| A [auth H] | C1-set_1 | e7k8rH2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: C1-set_1 | ECOD (1.6) |
| B [auth L] | C1-set_4 | e7k8rL2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: C1-set_4 | ECOD (1.6) |
| B [auth L] | V-set | e7k8rL1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set | ECOD (1.6) |
IMGT Antibody Annotation IMGT Database Homepage
| Chain | Protein Name | Description | Organism Name | Gene Allele Name(s) | Domain Name(s) | Receptor Type | Receptor Description | Provenance Source |
|---|---|---|---|---|---|---|---|---|
| A [auth H] | Fab C135, anti-SARS-CoV-2, neutralizing | VH-CH1 | Homo sapiens (human) | IGHV3-30*01, IGHV3-30*04, IGHV3-30*07, IGHV3-30*11, IGHV3-30*14, IGHV3-30*16, IGHV3-30*17, IGHV3-30-3*01, IGHV3-30-3*02, IGHV3-30-3*03, IGHJ4*01, IGHJ4*02, IGHJ4*03, IGHJ5*01, IGHJ8*01, IGHG1*03, IGHG1*08, IGHG1*06 | V-DOMAIN VH, C-DOMAIN CH1 | IG | FAB-GAMMA-1_KAPPA | IMGT (202415-0) |
| B [auth L] | Fab C135, anti-SARS-CoV-2, neutralizing | L-KAPPA | Homo sapiens (human) | IGKV1-5*01, IGKJ1*01, IGKC*01 | V-DOMAIN V-KAPPA, C-DOMAIN C-KAPPA | IG | FAB-GAMMA-1_KAPPA | IMGT (202415-0) |
SAbDab Antibody Annotation SAbDab Database Homepage
| Chain | Chain Class | Chain Subclass | Chain Type | Antigen Name(s) | Provenance Source |
|---|---|---|---|---|---|
| A [auth H] | Heavy Chain | IGHV3 | - | - | SAbDab (2024-04-19) |
| B [auth L] | Light Chain | IGKV1 | Kappa | - | SAbDab (2024-04-19) |
Thera-SAbDab Antibody Annotation Thera-SAbDab Database Homepage
| Chain | Name | Target | Provenance Source |
|---|---|---|---|
| A [auth H] | Ogalvibart | SARS-CoV-2 Spike RBD | Therapeutic SAbDab (2024-04-19) |
| B [auth L] | Ogalvibart | SARS-CoV-2 Spike RBD | Therapeutic SAbDab (2024-04-19) |
