7K8P

Crystal structure of an anti-SARS-CoV-2 human neutralizing antibody Fab fragment, C110

External Resource: Annotation


Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
A [auth H]d7k8ph1 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin automated matches automated matches Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
A [auth H]d7k8ph2 Artifacts Tags Tags Tags N-terminal Tags Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
B [auth L]d7k8pl2 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin C1 set domains (antibody constant domain-like) automated matches Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
B [auth L]d7k8pl1 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin automated matches automated matches Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
A [auth H]PF07654e7k8pH2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: PF07654ECOD (1.6)
A [auth H]PF07686e7k8pH1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: PF07686ECOD (1.6)
B [auth L]PF07654e7k8pL1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: PF07654ECOD (1.6)
B [auth L]PF07686e7k8pL2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: PF07686ECOD (1.6)

IMGT Antibody Annotation IMGT Database Homepage

ChainProtein NameDescriptionOrganism NameGene Allele Name(s)Domain Name(s)Receptor TypeReceptor DescriptionProvenance Source
A [auth H]Fab C110, anti-SARS-CoV-2, neutralizing VH-CH1 Homo sapiens (human) IGHV5-51*01, IGHV5-51*03, IGHJ3*02, IGHG1*03, IGHG1*08, IGHG1*06 V-DOMAIN VH, C-DOMAIN CH1 IG FAB-GAMMA-1_KAPPA IMGT (202416-0)
B [auth L]Fab C110, anti-SARS-CoV-2, neutralizing L-KAPPA Homo sapiens (human) IGKV1-5*03, IGKJ2*01, IGKJ2*02, IGKC*01 V-DOMAIN V-KAPPA, C-DOMAIN C-KAPPA IG FAB-GAMMA-1_KAPPA IMGT (202416-0)

SAbDab Antibody Annotation SAbDab Database Homepage

ChainChain ClassChain SubclassChain TypeAntigen Name(s) Provenance Source
A [auth H]Heavy ChainIGHV5 --SAbDab (2024-04-26)
B [auth L]Light ChainIGKV1 Kappa-SAbDab (2024-04-26)