7K7W

The X-ray crystal structure of SSR4, an S. pombe chromatin remodelling protein: native

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF08549	SWI/SNF and RSC complexes subunit Ssr4 N-terminal (SWI-SNF_Ssr4_N)	SWI/SNF and RSC complexes subunit Ssr4 N-terminal	This entry represents the N-terminal domain of SWI/SNF and RSC complexes subunit Ssr4 from S. pombe, a essential member of the chromatin structure remodelling complex (RSC) and the SWI/SNF complex [1,2]. The structure of this domain revealed that it ...	This entry represents the N-terminal domain of SWI/SNF and RSC complexes subunit Ssr4 from S. pombe, a essential member of the chromatin structure remodelling complex (RSC) and the SWI/SNF complex [1,2]. The structure of this domain revealed that it has a novel fold comprising an antiparallel beta-sheet of seven strands with alpha-helices on one side and random coil on the other [2]. It contains the highly conserved motif WxxxxxPxxGxxxxxxxxxxxxxxxDG. RSC is involved in transcription regulation and nucleosome positioning which controls, particularly, membrane and organelle development genes. The ATP-dependent chromatin remodelling complex SWI/SNF is required for the positive and negative regulation of gene expression of a large number of genes through the regulation of nucleosome remodelling [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	SWI/SNF and RSC complexes subunit ssr4	-	regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II regulation of biosynthetic process regulation of biological process cellular metabolic process biological regulation primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process positive regulation of macromolecule biosynthetic process positive regulation of gene expression, epigenetic positive regulation of metabolic process chromatin organization positive regulation of macromolecule metabolic process transcription initiation at RNA polymerase II promoter transcription initiation-coupled chromatin remodeling positive regulation of biological process positive regulation of cellular metabolic process protein-DNA complex organization cellular component organization positive regulation of biosynthetic process chromatin remodeling cellular component organization or biogenesis positive regulation of cellular process protein-containing complex organization epigenetic regulation of gene expression DNA-templated transcription initiation positive regulation of gene expression positive regulation of cellular biosynthetic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle SWI/SNF complex ATPase complex protein-containing complex catalytic complex protein-DNA complex nucleus nuclear protein-containing complex chromatin chromosome intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle SWI/SNF complex ATPase complex protein-containing complex catalytic complex protein-DNA complex nucleus nuclear protein-containing complex chromatin chromosome intracellular membrane-bounded organelle intracellular organelle organelle intracellular non-membrane-bounded organelle SWI/SNF superfamily-type complex non-membrane-bounded organelle RSC-type complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR013859	SWI/SNF and RSC complexes subunit Ssr4, N-terminal	Domain
A	IPR046464	SWI/SNF and RSC complexes subunit Ssr4, C-terminal	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.