7K17

Re-refined crystal structure of DNA-dependent protein kinase catalytic subunit complexed with Ku80 C-terminal helix

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	DNA-dependent protein kinase catalytic subunit	-	-	-
C [auth D], D [auth C]	X-ray repair cross-complementing protein 5	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding RNA binding U3 snoRNA binding snoRNA binding ATP-dependent activity, acting on DNA catalytic activity, acting on DNA DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding RNA binding U3 snoRNA binding snoRNA binding ATP-dependent activity, acting on DNA catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid catalytic activity ATP-dependent activity telomeric DNA binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein-containing complex binding ubiquitin protein ligase binding protein binding ubiquitin-like protein ligase binding enzyme binding DNA end binding DNA helicase activity helicase activity damaged DNA binding enzyme regulator activity enzyme activator activity molecular function activator activity molecular function regulator activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process developmental process stem cell proliferation cell population proliferation cellular developmental process hemopoiesis cell differentiation anatomical structure development hematopoietic stem cell proliferation cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process developmental process stem cell proliferation cell population proliferation cellular developmental process hemopoiesis cell differentiation anatomical structure development hematopoietic stem cell proliferation cell development response to chemical response to xenobiotic stimulus biological process involved in interspecies interaction between organisms immune response response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus immune system process defense response to other organism innate immune response response to external biotic stimulus regulation of biological process regulation of cellular process regulation of smooth muscle cell proliferation regulation of cell population proliferation biological regulation muscle cell proliferation smooth muscle cell proliferation response to X-ray cellular response to ionizing radiation cellular response to radiation cellular response to environmental stimulus cellular response to X-ray response to ionizing radiation response to radiation response to abiotic stimulus cellular response to abiotic stimulus regulation of catalytic activity regulation of transferase activity regulation of DNA biosynthetic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of nucleobase-containing compound metabolic process cellular metabolic process regulation of cellular metabolic process primary metabolic process DNA metabolic process organic cyclic compound metabolic process regulation of molecular function biosynthetic process positive regulation of DNA metabolic process organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process DNA biosynthetic process regulation of DNA metabolic process regulation of telomerase activity cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process nucleic acid biosynthetic process positive regulation of molecular function organic substance metabolic process positive regulation of biosynthetic process positive regulation of cellular process regulation of biosynthetic process positive regulation of telomerase activity positive regulation of transferase activity positive regulation of catalytic activity positive regulation of DNA biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process positive regulation of cellular biosynthetic process positive regulation of organelle organization telomere organization RNA-templated DNA biosynthetic process telomere maintenance via telomere lengthening positive regulation of telomere maintenance via telomere lengthening positive regulation of telomere maintenance regulation of chromosome organization regulation of telomere maintenance via telomere lengthening regulation of organelle organization positive regulation of chromosome organization telomere maintenance positive regulation of telomere maintenance via telomerase regulation of telomere maintenance regulation of cellular component organization positive regulation of cellular component organization cellular component organization cellular component organization or biogenesis telomere maintenance via telomerase chromosome organization regulation of telomere maintenance via telomerase organelle organization protein localization localization cellular localization protein localization to chromosome protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to chromosome, telomeric region positive regulation of nervous system development multicellular organismal process regulation of developmental process regulation of cell differentiation regulation of neurogenesis regulation of cell development regulation of nervous system development positive regulation of developmental process multicellular organism development neurogenesis positive regulation of cell differentiation positive regulation of neurogenesis regulation of multicellular organismal process system development regulation of multicellular organismal development positive regulation of cell development nervous system development positive regulation of multicellular organismal process positive regulation of phosphorylation positive regulation of phosphate metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process phosphorus metabolic process protein modification process positive regulation of protein phosphorylation protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process positive regulation of kinase activity regulation of kinase activity macromolecule modification regulation of phosphorus metabolic process regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of protein modification process protein metabolic process positive regulation of protein kinase activity organonitrogen compound metabolic process regulation of protein kinase activity regulation of phosphorylation response to osmotic stress cellular response to salt stress cellular hyperosmotic salinity response cellular response to chemical stress cellular response to osmotic stress response to salt stress hyperosmotic salinity response cellular response to chemical stimulus hyperosmotic response cellular hyperosmotic response negative regulation of biological process negative regulation of cellular metabolic process negative regulation of RNA biosynthetic process DNA-templated transcription regulation of RNA metabolic process negative regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription negative regulation of metabolic process negative regulation of cellular biosynthetic process regulation of gene expression negative regulation of macromolecule biosynthetic process regulation of DNA-templated transcription negative regulation of RNA metabolic process RNA metabolic process RNA biosynthetic process negative regulation of cellular process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process gene expression negative regulation of biosynthetic process regulation of defense response positive regulation of response to biotic stimulus regulation of response to biotic stimulus regulation of response to external stimulus positive regulation of response to stimulus positive regulation of response to external stimulus positive regulation of immune response regulation of response to stress regulation of immune system process positive regulation of immune system process positive regulation of innate immune response regulation of innate immune response regulation of response to stimulus positive regulation of defense response activation of innate immune response regulation of immune response activation of immune response cellular response to gamma radiation response to gamma radiation regulation of t-circle formation cellular component biogenesis cellular component assembly negative regulation of cellular component organization formation of extrachromosomal circular DNA regulation of cellular component biogenesis negative regulation of t-circle formation telomere maintenance via telomere trimming t-circle formation negative regulation of DNA metabolic process DNA recombination stem cell differentiation hematopoietic stem cell differentiation hematopoietic progenitor cell differentiation recombinational repair DNA repair response to organic substance response to lipid response to fatty acid response to oxygen-containing compound cellular response to oxygen-containing compound cellular response to fatty acid cellular response to lipid cellular response to organic substance double-strand break repair response to cytokine response to leukemia inhibitory factor cellular response to leukemia inhibitory factor cellular response to cytokine stimulus double-strand break repair via nonhomologous end joining ribonucleoprotein complex biogenesis organelle assembly protein-containing complex organization non-membrane-bounded organelle assembly ribosomal small subunit assembly protein-RNA complex assembly ribosomal small subunit biogenesis ribosome biogenesis protein-RNA complex organization cytosolic ribosome assembly protein-containing complex assembly small-subunit processome assembly cytosolic small ribosomal subunit assembly ribosome assembly	membrane cellular anatomical entity intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle protein-containing complex organelle nucleus nuclear protein-containing complex Ku70:Ku80 complex intracellular membrane-bounded organelle preribosome membrane cellular anatomical entity intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle protein-containing complex organelle nucleus nuclear protein-containing complex Ku70:Ku80 complex intracellular membrane-bounded organelle preribosome ribonucleoprotein complex small-subunit processome catalytic complex transferase complex protein kinase complex transferase complex, transferring phosphorus-containing groups DNA-dependent protein kinase complex serine/threonine protein kinase complex intracellular non-membrane-bounded organelle chromosome chromosome, telomeric region chromosomal region non-membrane-bounded organelle membrane-enclosed lumen nucleolus intracellular organelle lumen organelle lumen nuclear lumen cell periphery plasma membrane nucleoplasm nonhomologous end joining complex intracellular protein-containing complex DNA repair complex extracellular region DNA-dependent protein kinase-DNA ligase 4 complex vesicle lumen intracellular vesicle cytoplasmic vesicle lumen secretory granule lumen endomembrane system cytoplasmic vesicle secretory granule secretory vesicle vesicle protein-DNA complex telomere cap complex chromosome, telomeric repeat region nuclear telomere cap complex site of DNA damage

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C [auth D], D [auth C]	IPR036494	Ku, C-terminal domain superfamily	Homologous Superfamily
C [auth D], D [auth C]	IPR016194	SPOC-like, C-terminal domain superfamily	Homologous Superfamily
C [auth D], D [auth C]	IPR006164	Ku70/Ku80 beta-barrel domain	Domain
C [auth D], D [auth C]	IPR036465	von Willebrand factor A-like domain superfamily	Homologous Superfamily
C [auth D], D [auth C]	IPR002035	von Willebrand factor, type A	Domain
C [auth D], D [auth C]	IPR005161	Ku70/Ku80, N-terminal alpha/beta	Domain
C [auth D], D [auth C]	IPR014893	Ku, C-terminal	Domain
C [auth D], D [auth C]	IPR005160	Ku70/Ku80 C-terminal arm	Domain
C [auth D], D [auth C]	IPR024193	Ku80	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
C [auth D], D [auth C]	Pharos: P13010	primitive neuroectodermal tumor Adenocarcinoma of Lung atypical teratoid rhabdoid tumor large cell medulloblastoma lupus erythematosus medulloblastoma ovarian cancer systemic lupus erythematosus breast cancer glioblastoma lung adenocarcinoma lymphoplasmacytic lymphoma myopathy plasma cell myeloma breast carcinoma primitive neuroectodermal tumor Adenocarcinoma of Lung atypical teratoid rhabdoid tumor large cell medulloblastoma lupus erythematosus medulloblastoma ovarian cancer systemic lupus erythematosus breast cancer glioblastoma lung adenocarcinoma lymphoplasmacytic lymphoma myopathy plasma cell myeloma breast carcinoma Hodgkins lymphoma lung cancer malignant glioma osteosarcoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.