7K08

Cryo-EM structure of the nonameric EscV cytosolic domain from the type III secretion system

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00771	e7k08A4	A: alpha arrays	X: helical domain in flagellar biosynthesis protein flhA (From Topology)	H: helical domain in flagellar biosynthesis protein flhA (From Topology)	T: helical domain in flagellar biosynthesis protein flhA	F: PF00771	ECOD (1.6)
A	F_UNCLASSIFIED	e7k08A1	A: a+b two layers	X: ferredoxin-like domain in flagellar biosynthesis protein flhA (From Topology)	H: ferredoxin-like domain in flagellar biosynthesis protein flhA (From Topology)	T: ferredoxin-like domain in flagellar biosynthesis protein flhA	F: F_UNCLASSIFIED	ECOD (1.6)
A	F_UNCLASSIFIED	e7k08A3	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF00771	e7k08A2	A: a/b three-layered sandwiches	X: a/b domain in flagellar biosynthesis protein flhA (From Topology)	H: a/b domain in flagellar biosynthesis protein flhA (From Topology)	T: a/b domain in flagellar biosynthesis protein flhA	F: PF00771	ECOD (1.6)
B	PF00771	e7k08B2	A: alpha arrays	X: helical domain in flagellar biosynthesis protein flhA (From Topology)	H: helical domain in flagellar biosynthesis protein flhA (From Topology)	T: helical domain in flagellar biosynthesis protein flhA	F: PF00771	ECOD (1.6)
B	F_UNCLASSIFIED	e7k08B4	A: a+b two layers	X: ferredoxin-like domain in flagellar biosynthesis protein flhA (From Topology)	H: ferredoxin-like domain in flagellar biosynthesis protein flhA (From Topology)	T: ferredoxin-like domain in flagellar biosynthesis protein flhA	F: F_UNCLASSIFIED	ECOD (1.6)
B	F_UNCLASSIFIED	e7k08B1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF00771	e7k08B3	A: a/b three-layered sandwiches	X: a/b domain in flagellar biosynthesis protein flhA (From Topology)	H: a/b domain in flagellar biosynthesis protein flhA (From Topology)	T: a/b domain in flagellar biosynthesis protein flhA	F: PF00771	ECOD (1.6)
D	PF00771	e7k08D2	A: alpha arrays	X: helical domain in flagellar biosynthesis protein flhA (From Topology)	H: helical domain in flagellar biosynthesis protein flhA (From Topology)	T: helical domain in flagellar biosynthesis protein flhA	F: PF00771	ECOD (1.6)
D	F_UNCLASSIFIED	e7k08D4	A: a+b two layers	X: ferredoxin-like domain in flagellar biosynthesis protein flhA (From Topology)	H: ferredoxin-like domain in flagellar biosynthesis protein flhA (From Topology)	T: ferredoxin-like domain in flagellar biosynthesis protein flhA	F: F_UNCLASSIFIED	ECOD (1.6)
D	F_UNCLASSIFIED	e7k08D1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: F_UNCLASSIFIED	ECOD (1.6)
D	PF00771	e7k08D3	A: a/b three-layered sandwiches	X: a/b domain in flagellar biosynthesis protein flhA (From Topology)	H: a/b domain in flagellar biosynthesis protein flhA (From Topology)	T: a/b domain in flagellar biosynthesis protein flhA	F: PF00771	ECOD (1.6)
G	PF00771	e7k08G3	A: alpha arrays	X: helical domain in flagellar biosynthesis protein flhA (From Topology)	H: helical domain in flagellar biosynthesis protein flhA (From Topology)	T: helical domain in flagellar biosynthesis protein flhA	F: PF00771	ECOD (1.6)
G	F_UNCLASSIFIED	e7k08G2	A: a+b two layers	X: ferredoxin-like domain in flagellar biosynthesis protein flhA (From Topology)	H: ferredoxin-like domain in flagellar biosynthesis protein flhA (From Topology)	T: ferredoxin-like domain in flagellar biosynthesis protein flhA	F: F_UNCLASSIFIED	ECOD (1.6)
G	F_UNCLASSIFIED	e7k08G4	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: F_UNCLASSIFIED	ECOD (1.6)
G	PF00771	e7k08G1	A: a/b three-layered sandwiches	X: a/b domain in flagellar biosynthesis protein flhA (From Topology)	H: a/b domain in flagellar biosynthesis protein flhA (From Topology)	T: a/b domain in flagellar biosynthesis protein flhA	F: PF00771	ECOD (1.6)
C	PF00771	e7k08C3	A: alpha arrays	X: helical domain in flagellar biosynthesis protein flhA (From Topology)	H: helical domain in flagellar biosynthesis protein flhA (From Topology)	T: helical domain in flagellar biosynthesis protein flhA	F: PF00771	ECOD (1.6)
C	F_UNCLASSIFIED	e7k08C4	A: a+b two layers	X: ferredoxin-like domain in flagellar biosynthesis protein flhA (From Topology)	H: ferredoxin-like domain in flagellar biosynthesis protein flhA (From Topology)	T: ferredoxin-like domain in flagellar biosynthesis protein flhA	F: F_UNCLASSIFIED	ECOD (1.6)
C	F_UNCLASSIFIED	e7k08C1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: F_UNCLASSIFIED	ECOD (1.6)
C	PF00771	e7k08C2	A: a/b three-layered sandwiches	X: a/b domain in flagellar biosynthesis protein flhA (From Topology)	H: a/b domain in flagellar biosynthesis protein flhA (From Topology)	T: a/b domain in flagellar biosynthesis protein flhA	F: PF00771	ECOD (1.6)
E	PF00771	e7k08E4	A: alpha arrays	X: helical domain in flagellar biosynthesis protein flhA (From Topology)	H: helical domain in flagellar biosynthesis protein flhA (From Topology)	T: helical domain in flagellar biosynthesis protein flhA	F: PF00771	ECOD (1.6)
E	F_UNCLASSIFIED	e7k08E3	A: a+b two layers	X: ferredoxin-like domain in flagellar biosynthesis protein flhA (From Topology)	H: ferredoxin-like domain in flagellar biosynthesis protein flhA (From Topology)	T: ferredoxin-like domain in flagellar biosynthesis protein flhA	F: F_UNCLASSIFIED	ECOD (1.6)
E	F_UNCLASSIFIED	e7k08E1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: F_UNCLASSIFIED	ECOD (1.6)
E	PF00771	e7k08E2	A: a/b three-layered sandwiches	X: a/b domain in flagellar biosynthesis protein flhA (From Topology)	H: a/b domain in flagellar biosynthesis protein flhA (From Topology)	T: a/b domain in flagellar biosynthesis protein flhA	F: PF00771	ECOD (1.6)
F	PF00771	e7k08F4	A: alpha arrays	X: helical domain in flagellar biosynthesis protein flhA (From Topology)	H: helical domain in flagellar biosynthesis protein flhA (From Topology)	T: helical domain in flagellar biosynthesis protein flhA	F: PF00771	ECOD (1.6)
F	F_UNCLASSIFIED	e7k08F3	A: a+b two layers	X: ferredoxin-like domain in flagellar biosynthesis protein flhA (From Topology)	H: ferredoxin-like domain in flagellar biosynthesis protein flhA (From Topology)	T: ferredoxin-like domain in flagellar biosynthesis protein flhA	F: F_UNCLASSIFIED	ECOD (1.6)
F	F_UNCLASSIFIED	e7k08F1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: F_UNCLASSIFIED	ECOD (1.6)
F	PF00771	e7k08F2	A: a/b three-layered sandwiches	X: a/b domain in flagellar biosynthesis protein flhA (From Topology)	H: a/b domain in flagellar biosynthesis protein flhA (From Topology)	T: a/b domain in flagellar biosynthesis protein flhA	F: PF00771	ECOD (1.6)
H	PF00771	e7k08H4	A: alpha arrays	X: helical domain in flagellar biosynthesis protein flhA (From Topology)	H: helical domain in flagellar biosynthesis protein flhA (From Topology)	T: helical domain in flagellar biosynthesis protein flhA	F: PF00771	ECOD (1.6)
H	F_UNCLASSIFIED	e7k08H3	A: a+b two layers	X: ferredoxin-like domain in flagellar biosynthesis protein flhA (From Topology)	H: ferredoxin-like domain in flagellar biosynthesis protein flhA (From Topology)	T: ferredoxin-like domain in flagellar biosynthesis protein flhA	F: F_UNCLASSIFIED	ECOD (1.6)
H	F_UNCLASSIFIED	e7k08H2	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: F_UNCLASSIFIED	ECOD (1.6)
H	PF00771	e7k08H1	A: a/b three-layered sandwiches	X: a/b domain in flagellar biosynthesis protein flhA (From Topology)	H: a/b domain in flagellar biosynthesis protein flhA (From Topology)	T: a/b domain in flagellar biosynthesis protein flhA	F: PF00771	ECOD (1.6)
I	PF00771	e7k08I4	A: alpha arrays	X: helical domain in flagellar biosynthesis protein flhA (From Topology)	H: helical domain in flagellar biosynthesis protein flhA (From Topology)	T: helical domain in flagellar biosynthesis protein flhA	F: PF00771	ECOD (1.6)
I	F_UNCLASSIFIED	e7k08I2	A: a+b two layers	X: ferredoxin-like domain in flagellar biosynthesis protein flhA (From Topology)	H: ferredoxin-like domain in flagellar biosynthesis protein flhA (From Topology)	T: ferredoxin-like domain in flagellar biosynthesis protein flhA	F: F_UNCLASSIFIED	ECOD (1.6)
I	F_UNCLASSIFIED	e7k08I3	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: F_UNCLASSIFIED	ECOD (1.6)
I	PF00771	e7k08I1	A: a/b three-layered sandwiches	X: a/b domain in flagellar biosynthesis protein flhA (From Topology)	H: a/b domain in flagellar biosynthesis protein flhA (From Topology)	T: a/b domain in flagellar biosynthesis protein flhA	F: PF00771	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I	PF00771	FHIPEP family (FHIPEP)	FHIPEP family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I	Translocator EscV	-	protein localization establishment of protein localization cellular localization nitrogen compound transport transport secretion organic substance transport establishment of protein localization to extracellular region export from cell protein secretion establishment of localization protein localization to extracellular region localization secretion by cell protein transport protein localization establishment of protein localization cellular localization nitrogen compound transport transport secretion organic substance transport establishment of protein localization to extracellular region export from cell protein secretion establishment of localization protein localization to extracellular region localization secretion by cell protein transport cellular macromolecule localization macromolecule localization cellular process	cell periphery plasma membrane membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I	IPR042196	FHIPEP, domain 4	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I	IPR001712	Type III secretion system FHIPEP	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I	IPR042193	FHIPEP, domain 3	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I	IPR025505	FHIPEP conserved site	Conserved Site
A, B, C, D, E A, B, C, D, E, F, G, H, I	IPR006302	Type III secretion protein HrcV	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.

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7K08

Cryo-EM structure of the nonameric EscV cytosolic domain from the type III secretion system

External Resource: Annotation

Domain Annotation: ECOD Classification ECOD Database Homepage

Protein Family Annotation Pfam Database Homepage

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

InterPro: Protein Family Classification InterPro Database Homepage