Annotations: 7JNA

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	ASICs transmembrane helices-like	8106429	3002854	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Proton-activated chloride channel extracellular domain-like	8106421	3002853	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	ASICs transmembrane helices-like	8106431	3002854	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	ASICs transmembrane helices-like	8106431	3002854	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Proton-activated chloride channel extracellular domain-like	8106421	3002853	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	ASICs transmembrane helices-like	8106429	3002854	SCOP2B (2022-06-29)
A	SCOP2 Family	Proton-activated chloride channel TMEM206-like	8106419	4007842	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Proton-activated chloride channel extracellular domain-like	8106421	3002853	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	ASICs transmembrane helices-like	8106429	3002854	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	ASICs transmembrane helices-like	8106431	3002854	SCOP2 (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF15122	TMEM206 protein family (TMEM206)	TMEM206 protein family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Proton-activated chloride channel	pH-gated chloride channel activity monoatomic anion transmembrane transporter activity chloride transmembrane transporter activity gated channel activity monoatomic ion channel activity ligand-gated monoatomic anion channel activity ligand-gated channel activity ligand-gated monoatomic ion channel activity pH-gated monoatomic ion channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity monoatomic ion transmembrane transporter activity monoatomic anion channel activity transporter activity pH-gated chloride channel activity monoatomic anion transmembrane transporter activity chloride transmembrane transporter activity gated channel activity monoatomic ion channel activity ligand-gated monoatomic anion channel activity ligand-gated channel activity ligand-gated monoatomic ion channel activity pH-gated monoatomic ion channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity monoatomic ion transmembrane transporter activity monoatomic anion channel activity transporter activity transmembrane transporter activity inorganic anion transmembrane transporter activity chloride channel activity	localization transport monoatomic anion transport monoatomic ion transport chloride transport establishment of localization inorganic anion transport	cell surface cellular anatomical entity protein-containing complex transmembrane transporter complex membrane chloride channel complex membrane protein complex transporter complex monoatomic ion channel complex cell periphery plasma membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR029366	TMEM206 protein	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C	Pharos: Q9H813	Crohn disease interstitial cystitis Malignant neoplasm of breast ulcerative colitis ductal breast carcinoma in situ invasive ductal breast carcinoma Pick disease gastric carcinoma large cell medulloblastoma Sjogren syndrome

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C	OPM				Proton-activated chloride channel

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B, C	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B, C	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Channels: Other Ion Channels	proton-activated chloride (PAC/ASOR) channel, pH 8

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.