7JHI

Structure of human beta 1,3-N-acetylglucosaminyltransferase 2 iodide-derivative

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01762	e7jhiA1	A: a/b three-layered sandwiches	X: Nucleotide-diphospho-sugar transferases (From Topology)	H: Nucleotide-diphospho-sugar transferases (From Topology)	T: Nucleotide-diphospho-sugar transferases	F: PF01762	ECOD (1.6)
B	PF01762	e7jhiB1	A: a/b three-layered sandwiches	X: Nucleotide-diphospho-sugar transferases (From Topology)	H: Nucleotide-diphospho-sugar transferases (From Topology)	T: Nucleotide-diphospho-sugar transferases	F: PF01762	ECOD (1.6)
D	PF01762	e7jhiD1	A: a/b three-layered sandwiches	X: Nucleotide-diphospho-sugar transferases (From Topology)	H: Nucleotide-diphospho-sugar transferases (From Topology)	T: Nucleotide-diphospho-sugar transferases	F: PF01762	ECOD (1.6)
C	PF01762	e7jhiC1	A: a/b three-layered sandwiches	X: Nucleotide-diphospho-sugar transferases (From Topology)	H: Nucleotide-diphospho-sugar transferases (From Topology)	T: Nucleotide-diphospho-sugar transferases	F: PF01762	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF01762	Galactosyltransferase (Galactosyl_T)	Galactosyltransferase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2	UDP-glycosyltransferase activity glycosyltransferase activity beta-1,3-galactosyltransferase activity UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity transferase activity galactosyltransferase activity hexosyltransferase activity UDP-galactosyltransferase activity catalytic activity acetylglucosaminyltransferase activity N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity	carbohydrate derivative biosynthetic process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process carbohydrate derivative metabolic process macromolecule biosynthetic process organic substance metabolic process biosynthetic process aminoglycan metabolic process organic substance biosynthetic process aminoglycan biosynthetic process metabolic process cellular process carbohydrate derivative biosynthetic process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process carbohydrate derivative metabolic process macromolecule biosynthetic process organic substance metabolic process biosynthetic process aminoglycan metabolic process organic substance biosynthetic process aminoglycan biosynthetic process metabolic process cellular process macromolecule metabolic process poly-N-acetyllactosamine metabolic process poly-N-acetyllactosamine biosynthetic process multicellular organismal process axonogenesis cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis cellular component organization neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation anatomical structure development cellular component organization or biogenesis system development developmental process plasma membrane bounded cell projection organization axon guidance nervous system development axon development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron projection guidance neuron development system process sensory perception of chemical stimulus sensory perception nervous system process sensory perception of smell mucopolysaccharide metabolic process glycosaminoglycan metabolic process sulfur compound biosynthetic process keratan sulfate metabolic process sulfur compound metabolic process glycosaminoglycan biosynthetic process keratan sulfate biosynthetic process protein metabolic process protein modification process glycoprotein biosynthetic process primary metabolic process glycoprotein metabolic process protein glycosylation glycosylation macromolecule modification macromolecule glycosylation protein O-linked glycosylation O-glycan processing cellular response to stimulus response to organic substance response to stimulus response to cytokine response to leukemia inhibitory factor cellular response to leukemia inhibitory factor cellular response to chemical stimulus response to chemical cellular response to cytokine stimulus cellular response to organic substance	membrane cellular anatomical entity membrane-bounded organelle Golgi membrane intracellular anatomical structure Golgi apparatus intracellular membrane-bounded organelle endomembrane system intracellular organelle bounding membrane of organelle organelle cytoplasm organelle membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR002659	Glycosyl transferase, family 31	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: Q9NY97	rheumatoid arthritis Graves disease ankylosing spondylitis Crohn disease juvenile dermatomyositis medulloblastoma ovarian cancer schizophrenia astrocytic tumor ductal breast carcinoma in situ hydrocephalus malignant mesothelioma oligodendroglioma psoriasis Sjogren syndrome rheumatoid arthritis Graves disease ankylosing spondylitis Crohn disease juvenile dermatomyositis medulloblastoma ovarian cancer schizophrenia astrocytic tumor ductal breast carcinoma in situ hydrocephalus malignant mesothelioma oligodendroglioma psoriasis Sjogren syndrome breast cancer exocrine pancreatic carcinoma invasive ductal breast carcinoma malignant pancreatic neoplasm osteosarcoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.