Annotations: 7JG2

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
E	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8068374	3000071	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF07654	e7jg2A1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
B	PF07654	e7jg2B2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
C	PF07654	e7jg2C2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
D	PF07654	e7jg2D2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
E	PF07686	e7jg2E2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
A, B, C, D	IgA	CH1-CH2-CH3	Homo sapiens (human)	IGHA*03	C-DOMAIN CH1, C-DOMAIN CH2, C-DOMAIN CH3	IG	CH1-CH2-CH3	IMGT (202418-0)
E	Polymeric immunoglobulin receptor	5V-LIKE	Homo sapiens (human)	PIGR	V-LIKE-DOMAIN V-LIKE	RPI	PIGR	IMGT (202418-0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF07654	Immunoglobulin C1-set domain (C1-set)	Immunoglobulin C1-set domain	-	Domain
E	PF07686	Immunoglobulin V-set domain (V-set)	Immunoglobulin V-set domain	This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.	Domain
F [auth J]	PF15097	Immunoglobulin J chain (Ig_J_chain)	Immunoglobulin J chain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Igh protein	protein binding binding signaling receptor binding immunoglobulin receptor binding antigen binding	humoral immune response biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response immune response antibacterial humoral response defense response to symbiont response to external stimulus antimicrobial humoral response response to biotic stimulus defense response to bacterium defense response to other organism response to stress immune system process humoral immune response biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response immune response antibacterial humoral response defense response to symbiont response to external stimulus antimicrobial humoral response response to biotic stimulus defense response to bacterium defense response to other organism response to stress immune system process response to bacterium response to external biotic stimulus adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity positive regulation of biological process positive regulation of response to stimulus complement activation humoral immune response mediated by circulating immunoglobulin positive regulation of immune response leukocyte mediated immunity regulation of immune system process positive regulation of immune system process complement activation, classical pathway regulation of biological process biological regulation immunoglobulin mediated immune response adaptive immune response immune effector process regulation of response to stimulus B cell mediated immunity regulation of immune response activation of immune response	protein-containing complex extracellular region extracellular space cellular anatomical entity immunoglobulin complex, circulating immunoglobulin complex
E	Polymeric immunoglobulin receptor	polymeric immunoglobulin binding protein-containing complex binding binding immunoglobulin binding epidermal growth factor receptor binding protein binding signaling receptor binding growth factor receptor binding molecular transducer activity immunoglobulin receptor activity transmembrane signaling receptor activity signaling receptor activity polymeric immunoglobulin receptor activity immune receptor activity	cellular response to stimulus immune response-regulating cell surface receptor signaling pathway regulation of biological process regulation of cellular process response to stimulus cell surface receptor signaling pathway signaling immune response biological regulation cell communication Fc receptor signaling pathway immune response-regulating signaling pathway regulation of response to stimulus immune system process cellular response to stimulus immune response-regulating cell surface receptor signaling pathway regulation of biological process regulation of cellular process response to stimulus cell surface receptor signaling pathway signaling immune response biological regulation cell communication Fc receptor signaling pathway immune response-regulating signaling pathway regulation of response to stimulus immune system process regulation of immune response cellular process regulation of immune system process signal transduction cell surface receptor protein tyrosine kinase signaling pathway ERBB signaling pathway epidermal growth factor receptor signaling pathway enzyme-linked receptor protein signaling pathway protein localization localization cellular localization receptor clustering cellular macromolecule localization macromolecule localization localization within membrane protein localization to membrane multicellular organismal process transport establishment of localization immunoglobulin transcytosis in epithelial cells vesicle-mediated transport immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor transcytosis mucosal immune response organ or tissue specific immune response system process nervous system process detection of chemical stimulus involved in sensory perception of bitter taste detection of chemical stimulus involved in sensory perception of taste detection of stimulus sensory perception of chemical stimulus sensory perception sensory perception of taste response to chemical detection of chemical stimulus sensory perception of bitter taste detection of stimulus involved in sensory perception detection of chemical stimulus involved in sensory perception	protein-containing complex receptor complex endosome membrane membrane-bounded organelle intracellular anatomical structure membrane endosome intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle recycling endosome endomembrane system intracellular organelle cytoplasmic vesicle membrane protein-containing complex receptor complex endosome membrane membrane-bounded organelle intracellular anatomical structure membrane endosome intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle recycling endosome endomembrane system intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle recycling endosome membrane vesicle membrane cytoplasmic vesicle organelle cytoplasm vesicle organelle membrane IgA immunoglobulin complex, circulating secretory IgA immunoglobulin complex extracellular region IgA immunoglobulin complex extracellular space polymeric IgA immunoglobulin complex immunoglobulin complex, circulating immunoglobulin complex cell periphery plasma membrane
F [auth J]	Immunoglobulin J chain	identical protein binding protein binding binding protein homodimerization activity protein dimerization activity glycosaminoglycan binding carbohydrate derivative binding peptidoglycan binding protein-containing complex binding immunoglobulin binding IgA binding cation binding ion binding phosphatidylcholine binding identical protein binding protein binding binding protein homodimerization activity protein dimerization activity glycosaminoglycan binding carbohydrate derivative binding peptidoglycan binding protein-containing complex binding immunoglobulin binding IgA binding cation binding ion binding phosphatidylcholine binding phospholipid binding lipid binding quaternary ammonium group binding small molecule binding signaling receptor binding immunoglobulin receptor binding protein-macromolecule adaptor activity molecular adaptor activity DNA binding organic cyclic compound binding single-stranded DNA binding nucleic acid binding antigen binding	cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis positive regulation of metabolic process regulation of biological process positive regulation of respiratory burst respiratory burst biological regulation positive regulation of biological process metabolic process cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis positive regulation of metabolic process regulation of biological process positive regulation of respiratory burst respiratory burst biological regulation positive regulation of biological process metabolic process regulation of respiratory burst regulation of metabolic process response to stimulus immune response immune system process adaptive immune response humoral immune response biological process involved in interspecies interaction between organisms response to other organism defense response antibacterial humoral response defense response to symbiont response to external stimulus antimicrobial humoral response response to biotic stimulus defense response to bacterium defense response to other organism response to stress response to bacterium response to external biotic stimulus innate immune response multicellular organismal process renal system process system process glomerular filtration renal filtration	IgA immunoglobulin complex, circulating dimeric IgA immunoglobulin complex protein-containing complex extracellular region IgA immunoglobulin complex extracellular space cellular anatomical entity polymeric IgA immunoglobulin complex immunoglobulin complex, circulating immunoglobulin complex secretory IgA immunoglobulin complex monomeric IgA immunoglobulin complex IgM immunoglobulin complex IgM immunoglobulin complex, circulating IgA immunoglobulin complex, circulating dimeric IgA immunoglobulin complex protein-containing complex extracellular region IgA immunoglobulin complex extracellular space cellular anatomical entity polymeric IgA immunoglobulin complex immunoglobulin complex, circulating immunoglobulin complex secretory IgA immunoglobulin complex monomeric IgA immunoglobulin complex IgM immunoglobulin complex IgM immunoglobulin complex, circulating pentameric IgM immunoglobulin complex secretory dimeric IgA immunoglobulin complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR003597	Immunoglobulin C1-set	Domain
A, B, C, D	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, B, C, D	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A, B, C, D	IPR003599	Immunoglobulin subtype	Domain
A, B, C, D	IPR007110	Immunoglobulin-like domain	Domain
A, B, C, D	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site	Conserved Site
E	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
E	IPR003599	Immunoglobulin subtype	Domain
E	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
E	IPR013106	Immunoglobulin V-set domain	Domain
E	IPR007110	Immunoglobulin-like domain	Domain
F [auth J]	IPR024110	Immunoglobulin J chain	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.