Annotations: 7JG1

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF07654	e7jg1A2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
B	PF07654	e7jg1B2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
C	PF07654	e7jg1C2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
D	PF07654	e7jg1D1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
A, B, C, D	IgA	1C-LIKE	-	IGHA*03	C-DOMAIN CH1, C-DOMAIN CH2, C-DOMAIN CH3	IG	(_CH1-HINGE-REGION-CH2-CH3_CH1-HINGE-REGION-CH2-CH3_CH1-HINGE-REGI	IMGT (202418-0)
E [auth J]	IGH PROTEIN,J	null	-	-	-	IG	ON-CH2-CH3_CH1-HINGE-REGION-CH2-CH3)	IMGT (202418-0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF07654	Immunoglobulin C1-set domain (C1-set)	Immunoglobulin C1-set domain	-	Domain
E [auth J]	PF15097	Immunoglobulin J chain (Ig_J_chain)	Immunoglobulin J chain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Igh protein	protein binding binding signaling receptor binding immunoglobulin receptor binding antigen binding	humoral immune response biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response immune response antibacterial humoral response defense response to symbiont response to external stimulus antimicrobial humoral response response to biotic stimulus defense response to bacterium defense response to other organism response to stress immune system process humoral immune response biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response immune response antibacterial humoral response defense response to symbiont response to external stimulus antimicrobial humoral response response to biotic stimulus defense response to bacterium defense response to other organism response to stress immune system process response to bacterium response to external biotic stimulus adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity positive regulation of biological process positive regulation of response to stimulus complement activation humoral immune response mediated by circulating immunoglobulin positive regulation of immune response leukocyte mediated immunity regulation of immune system process positive regulation of immune system process complement activation, classical pathway regulation of biological process biological regulation immunoglobulin mediated immune response adaptive immune response immune effector process regulation of response to stimulus B cell mediated immunity regulation of immune response activation of immune response	protein-containing complex extracellular region extracellular space cellular anatomical entity immunoglobulin complex, circulating immunoglobulin complex
E [auth J]	Immunoglobulin J chain	identical protein binding protein binding binding protein homodimerization activity protein dimerization activity glycosaminoglycan binding carbohydrate derivative binding peptidoglycan binding protein-containing complex binding immunoglobulin binding IgA binding cation binding ion binding phosphatidylcholine binding identical protein binding protein binding binding protein homodimerization activity protein dimerization activity glycosaminoglycan binding carbohydrate derivative binding peptidoglycan binding protein-containing complex binding immunoglobulin binding IgA binding cation binding ion binding phosphatidylcholine binding phospholipid binding lipid binding quaternary ammonium group binding small molecule binding signaling receptor binding immunoglobulin receptor binding protein-macromolecule adaptor activity molecular adaptor activity DNA binding organic cyclic compound binding single-stranded DNA binding nucleic acid binding antigen binding	cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis positive regulation of metabolic process regulation of biological process positive regulation of respiratory burst respiratory burst biological regulation positive regulation of biological process metabolic process cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis positive regulation of metabolic process regulation of biological process positive regulation of respiratory burst respiratory burst biological regulation positive regulation of biological process metabolic process regulation of respiratory burst regulation of metabolic process response to stimulus immune response immune system process adaptive immune response humoral immune response biological process involved in interspecies interaction between organisms response to other organism defense response antibacterial humoral response defense response to symbiont response to external stimulus antimicrobial humoral response response to biotic stimulus defense response to bacterium defense response to other organism response to stress response to bacterium response to external biotic stimulus innate immune response multicellular organismal process renal system process system process glomerular filtration renal filtration	IgA immunoglobulin complex, circulating dimeric IgA immunoglobulin complex protein-containing complex extracellular region IgA immunoglobulin complex extracellular space cellular anatomical entity polymeric IgA immunoglobulin complex immunoglobulin complex, circulating immunoglobulin complex secretory IgA immunoglobulin complex monomeric IgA immunoglobulin complex IgM immunoglobulin complex IgM immunoglobulin complex, circulating IgA immunoglobulin complex, circulating dimeric IgA immunoglobulin complex protein-containing complex extracellular region IgA immunoglobulin complex extracellular space cellular anatomical entity polymeric IgA immunoglobulin complex immunoglobulin complex, circulating immunoglobulin complex secretory IgA immunoglobulin complex monomeric IgA immunoglobulin complex IgM immunoglobulin complex IgM immunoglobulin complex, circulating pentameric IgM immunoglobulin complex secretory dimeric IgA immunoglobulin complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR003597	Immunoglobulin C1-set	Domain
A, B, C, D	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, B, C, D	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A, B, C, D	IPR003599	Immunoglobulin subtype	Domain
A, B, C, D	IPR007110	Immunoglobulin-like domain	Domain
A, B, C, D	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site	Conserved Site
E [auth J]	IPR024110	Immunoglobulin J chain	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.