Annotations: 7EP2

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF22964	e7ep2A1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF22964	ECOD (1.6)
B [auth C]	PF22964	e7ep2C1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF22964	ECOD (1.6)
C [auth D]	PF22964	e7ep2D1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF22964	ECOD (1.6)
D [auth B]	PF22964	e7ep2B1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF22964	ECOD (1.6)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B [auth C], C [auth D], D [auth B]	Protein zyg-11 homolog B	-	positive regulation of proteasomal protein catabolic process catabolic process positive regulation of protein metabolic process proteolysis involved in protein catabolic process positive regulation of biological process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process regulation of ubiquitin-dependent protein catabolic process regulation of primary metabolic process positive regulation of metabolic process organic substance metabolic process positive regulation of ubiquitin-dependent protein catabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process modification-dependent macromolecule catabolic process positive regulation of proteasomal protein catabolic process catabolic process positive regulation of protein metabolic process proteolysis involved in protein catabolic process positive regulation of biological process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process regulation of ubiquitin-dependent protein catabolic process regulation of primary metabolic process positive regulation of metabolic process organic substance metabolic process positive regulation of ubiquitin-dependent protein catabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process modification-dependent macromolecule catabolic process proteolysis positive regulation of macromolecule metabolic process protein metabolic process organonitrogen compound catabolic process regulation of biological process organonitrogen compound metabolic process regulation of protein metabolic process biological regulation primary metabolic process proteasomal protein catabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of catabolic process regulation of proteasomal ubiquitin-dependent protein catabolic process modification-dependent protein catabolic process positive regulation of proteolysis regulation of proteasomal protein catabolic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process metabolic process ubiquitin-dependent protein catabolic process macromolecule metabolic process regulation of metabolic process organic substance catabolic process regulation of protein catabolic process protein quality control for misfolded or incompletely synthesized proteins	intracellular anatomical structure cytoplasm cellular anatomical entity cullin-RING ubiquitin ligase complex protein-containing complex ubiquitin ligase complex catalytic complex Cul2-RING ubiquitin ligase complex transferase complex intracellular protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B [auth C], C [auth D], D [auth B]	IPR011989	Armadillo-like helical	Homologous Superfamily
A, B [auth C], C [auth D], D [auth B]	IPR032675	Leucine-rich repeat domain superfamily	Homologous Superfamily
A, B [auth C], C [auth D], D [auth B]	IPR016024	Armadillo-type fold	Homologous Superfamily
A, B [auth C], C [auth D], D [auth B]	IPR001611	Leucine-rich repeat	Repeat

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B [auth C], C [auth D], D [auth B]	Pharos: Q9C0D3	atypical teratoid rhabdoid tumor Emery-Dreifuss muscular dystrophy limb-girdle muscular dystrophy malignant pancreatic neoplasm ovarian cancer Pick disease rheumatoid arthritis cystic fibrosis glioblastoma malignant ependymoma medulloblastoma pancreatic ductal adenocarcinoma pilocytic astrocytoma sinusitis Duchenne muscular dystrophy atypical teratoid rhabdoid tumor Emery-Dreifuss muscular dystrophy limb-girdle muscular dystrophy malignant pancreatic neoplasm ovarian cancer Pick disease rheumatoid arthritis cystic fibrosis glioblastoma malignant ependymoma medulloblastoma pancreatic ductal adenocarcinoma pilocytic astrocytoma sinusitis Duchenne muscular dystrophy large cell medulloblastoma malignant glioma osteosarcoma peripheral arterial disease primitive neuroectodermal tumor

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.