Annotations: 7E34

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d7e34a1	Alpha and beta proteins (a+b)	Protein kinase-like (PK-like)	Protein kinase-like (PK-like)	Protein kinases, catalytic subunit	Cyclin-dependent PK, CDK2	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d7e34a2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Protein kinase-like (PK-like)	8040310	3000066	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00069	e7e34A1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: PF00069	ECOD (1.6)
B	PF11357	e7e34B1	A: alpha arrays	X: HTH	H: HTH	T: Cyclin-like	F: PF11357	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00069	Protein kinase domain (Pkinase)	Protein kinase domain	-	Domain
B	PF11357	Cell cycle regulatory protein (Spy1)	Cell cycle regulatory protein	-	Family
C	PF09387	Mitochondrial RNA binding protein MRP (MRP)	Mitochondrial RNA binding protein MRP	MRP1 and MRP2 are mitochondrial RNA binding proteins that form a heteromeric complex. The MRP1/MRP2 heterotetrameric complex binds to guide RNAs and stabilises them in an unfolded conformation suitable for RNA-RNA hybridisation. Each MRP subunit ad ...	MRP1 and MRP2 are mitochondrial RNA binding proteins that form a heteromeric complex. The MRP1/MRP2 heterotetrameric complex binds to guide RNAs and stabilises them in an unfolded conformation suitable for RNA-RNA hybridisation. Each MRP subunit adopts a 'whirly' transcription factor fold [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Cyclin-dependent kinase 2	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity cyclin-dependent protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein binding protein domain specific binding cyclin binding protein serine kinase activity cation binding magnesium ion binding metal ion binding	response to organic substance response to stimulus response to chemical cellular process cell division microtubule organizing center organization microtubule cytoskeleton organization cellular component organization centrosome duplication organelle organization centrosome cycle microtubule-based process cell cycle cellular component organization or biogenesis response to organic substance response to stimulus response to chemical cellular process cell division microtubule organizing center organization microtubule cytoskeleton organization cellular component organization centrosome duplication organelle organization centrosome cycle microtubule-based process cell cycle cellular component organization or biogenesis cytoskeleton organization cell cycle process regulation of biosynthetic process regulation of biological process regulation of cellular process cellular biosynthetic process cellular metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression organic substance metabolic process biosynthetic process organic substance biosynthetic process regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of DNA replication positive regulation of biological process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of nucleobase-containing compound metabolic process primary metabolic process DNA metabolic process nucleic acid metabolic process organic cyclic compound metabolic process DNA replication positive regulation of DNA metabolic process regulation of DNA metabolic process regulation of DNA replication RNA metabolic process nucleobase-containing compound biosynthetic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process organic cyclic compound biosynthetic process cellular response to stimulus regulation of cell cycle phase transition DNA damage checkpoint signaling signaling negative regulation of biological process negative regulation of cell cycle cell cycle phase transition regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition intracellular signal transduction mitotic cell cycle negative regulation of mitotic cell cycle cell communication regulation of mitotic cell cycle mitotic DNA integrity checkpoint signaling cellular response to stress response to stress mitotic DNA damage checkpoint signaling negative regulation of cellular process negative regulation of cell cycle phase transition signal transduction regulation of cell cycle negative regulation of G1/S transition of mitotic cell cycle mitotic G1/S transition checkpoint signaling negative regulation of mitotic cell cycle phase transition regulation of cell cycle process negative regulation of cell cycle G1/S phase transition DNA integrity checkpoint signaling negative regulation of cell cycle process cell cycle checkpoint signaling regulation of mitotic cell cycle phase transition mitotic cell cycle checkpoint signaling mitotic G1 DNA damage checkpoint signaling mitotic cell cycle process regulation of G1/S transition of mitotic cell cycle DNA damage response signal transduction in response to DNA damage G1/S transition of mitotic cell cycle mitotic cell cycle phase transition cellular senescence centriole assembly organelle assembly non-membrane-bounded organelle assembly cellular component biogenesis cellular component assembly centriole replication organonitrogen compound metabolic process macromolecule modification protein metabolic process post-translational protein modification protein modification process protein phosphorylation phosphorylation phosphate-containing compound metabolic process phosphorus metabolic process DNA repair cell cycle G2/M phase transition regulation of G2/M transition of mitotic cell cycle G2/M transition of mitotic cell cycle regulation of cell cycle G2/M phase transition peptidyl-serine modification peptidyl-serine phosphorylation peptidyl-amino acid modification negative regulation of cellular metabolic process negative regulation of RNA biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of macromolecule biosynthetic process regulation of DNA-templated transcription negative regulation of RNA metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process negative regulation of biosynthetic process cellular response to nitrogen compound cellular response to inorganic substance response to oxygen-containing compound response to nitrogen compound cellular response to oxygen-containing compound response to inorganic substance cellular response to nitric oxide cellular response to chemical stimulus response to nitric oxide cellular response to reactive nitrogen species regulation of DNA-templated DNA replication initiation DNA-templated DNA replication DNA replication initiation regulation of DNA-templated DNA replication positive regulation of DNA-templated DNA replication positive regulation of DNA-templated DNA replication initiation small GTPase-mediated signal transduction Ras protein signal transduction intracellular signaling cassette localization transport monoatomic ion transport potassium ion transport monoatomic cation transport establishment of localization metal ion transport cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation positive regulation of cellular process positive regulation of macromolecule biosynthetic process positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process catabolic process regulation of anaphase-promoting complex-dependent catabolic process proteolysis involved in protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process regulation of ubiquitin-dependent protein catabolic process regulation of proteolysis involved in protein catabolic process regulation of proteolysis modification-dependent macromolecule catabolic process proteolysis organonitrogen compound catabolic process regulation of protein metabolic process proteasomal protein catabolic process protein catabolic process regulation of catabolic process regulation of proteasomal ubiquitin-dependent protein catabolic process modification-dependent protein catabolic process regulation of proteasomal protein catabolic process anaphase-promoting complex-dependent catabolic process ubiquitin-dependent protein catabolic process organic substance catabolic process regulation of protein catabolic process sexual reproduction reproductive process meiotic cell cycle positive regulation of organelle organization chromatin organization regulation of heterochromatin formation regulation of chromatin organization regulation of chromosome organization regulation of organelle organization positive regulation of chromosome organization negative regulation of gene expression negative regulation of gene expression, epigenetic regulation of cellular component organization positive regulation of cellular component organization protein-DNA complex organization positive regulation of heterochromatin formation positive regulation of chromatin organization chromatin remodeling heterochromatin formation protein-containing complex organization positive regulation of cellular component biogenesis epigenetic regulation of gene expression chromosome organization regulation of cellular component biogenesis	protein kinase complex transferase complex, transferring phosphorus-containing groups protein-containing complex catalytic complex serine/threonine protein kinase complex cyclin-dependent protein kinase holoenzyme complex transferase complex membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope nucleus protein kinase complex transferase complex, transferring phosphorus-containing groups protein-containing complex catalytic complex serine/threonine protein kinase complex cyclin-dependent protein kinase holoenzyme complex transferase complex membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope nucleus cellular anatomical entity intracellular membrane-bounded organelle endomembrane system cytoplasm cytosol transcription regulator complex sex chromosome intracellular non-membrane-bounded organelle chromosome non-membrane-bounded organelle X chromosome Cajal body membrane-enclosed lumen intracellular organelle lumen nuclear body nucleoplasm organelle lumen nuclear lumen Y chromosome cyclin E2-CDK2 complex male germ cell nucleus germ cell nucleus chromosome, telomeric region chromosomal region cyclin A2-CDK2 complex condensed chromosome centrosome microtubule organizing center cytoskeleton microtubule cytoskeleton cyclin E1-CDK2 complex endosome intracellular vesicle cytoplasmic vesicle vesicle cyclin A1-CDK2 complex
B	Speedy protein A	protein binding binding kinase binding enzyme binding protein kinase binding enzyme regulator activity kinase activator activity enzyme activator activity molecular function activator activity molecular function regulator activity protein kinase activator activity protein kinase regulator activity kinase regulator activity	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process regulation of biological process cell population proliferation regulation of cellular process positive regulation of cell population proliferation regulation of cell population proliferation biological regulation positive regulation of biological process positive regulation of cellular process cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process regulation of biological process cell population proliferation regulation of cellular process positive regulation of cell population proliferation regulation of cell population proliferation biological regulation positive regulation of biological process positive regulation of cellular process establishment of protein localization to telomere protein localization establishment of protein localization cellular localization protein localization to chromosome, telomeric region establishment of localization localization establishment of protein localization to organelle protein localization to chromosome cellular macromolecule localization macromolecule localization protein localization to organelle establishment of protein localization to chromosome developmental process spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation cellular developmental process oogenesis cell development cellular process involved in reproduction in multicellular organism female gamete generation cell differentiation anatomical structure development germ cell development mitotic cell cycle process cell cycle phase transition cell cycle G1/S transition of mitotic cell cycle cell cycle G1/S phase transition mitotic cell cycle mitotic cell cycle phase transition cell cycle process positive regulation of phosphorylation regulation of catalytic activity regulation of transferase activity positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process positive regulation of macromolecule metabolic process phosphorus metabolic process protein modification process positive regulation of protein phosphorylation protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation cellular metabolic process regulation of protein metabolic process regulation of cellular metabolic process primary metabolic process regulation of molecular function positive regulation of kinase activity regulation of kinase activity macromolecule modification regulation of phosphorus metabolic process metabolic process macromolecule metabolic process regulation of metabolic process regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of cellular metabolic process positive regulation of molecular function positive regulation of protein modification process organic substance metabolic process protein metabolic process positive regulation of protein kinase activity organonitrogen compound metabolic process positive regulation of transferase activity positive regulation of catalytic activity regulation of protein kinase activity regulation of macromolecule metabolic process regulation of phosphorylation establishment of organelle localization meiotic chromosome segregation meiotic attachment of telomere to nuclear envelope meiotic cell cycle process cellular component organization telomere localization meiosis I chromosome localization organelle localization establishment of localization in cell meiotic nuclear division cellular component organization or biogenesis chromosome segregation meiotic cell cycle organelle fission meiotic telomere clustering meiotic telomere tethering at nuclear periphery chromosome organization chromosome organization involved in meiotic cell cycle nuclear division organelle organization chromosome localization to nuclear envelope involved in homologous chromosome segregation telomere tethering at nuclear periphery meiosis I cell cycle process nuclear chromosome segregation chromosome attachment to the nuclear envelope homologous chromosome segregation establishment of chromosome localization telomere organization DNA metabolic process nucleic acid metabolic process telomere maintenance nucleobase-containing compound metabolic process organic cyclic compound metabolic process telomere capping male meiotic nuclear division	membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope nucleus cellular anatomical entity intracellular membrane-bounded organelle endomembrane system XY body sex chromosome intracellular non-membrane-bounded organelle chromosome membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope nucleus cellular anatomical entity intracellular membrane-bounded organelle endomembrane system XY body sex chromosome intracellular non-membrane-bounded organelle chromosome non-membrane-bounded organelle chromosome, telomeric region chromosomal region membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
C	SUN domain-containing protein 1	protein-membrane adaptor activity protein-macromolecule adaptor activity molecular adaptor activity lamin binding protein binding binding cytoskeleton-nuclear membrane anchor activity identical protein binding	maintenance of protein location protein localization cellular localization nuclear matrix anchoring at nuclear membrane maintenance of protein location in nucleus protein localization to nucleus maintenance of location maintenance of location in cell cellular component organization localization nucleus organization organelle organization nuclear matrix organization maintenance of protein location in cell cellular macromolecule localization maintenance of protein location protein localization cellular localization nuclear matrix anchoring at nuclear membrane maintenance of protein location in nucleus protein localization to nucleus maintenance of location maintenance of location in cell cellular component organization localization nucleus organization organelle organization nuclear matrix organization maintenance of protein location in cell cellular macromolecule localization macromolecule localization protein localization to organelle cellular process cellular component organization or biogenesis maintenance of protein localization in organelle developmental process spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation response to stimulus response to mechanical stimulus response to abiotic stimulus response to external stimulus centrosome localization microtubule organizing center localization establishment of organelle localization multicellular organismal process organelle transport along microtubule microtubule cytoskeleton organization telencephalon glial cell migration multicellular organism development telencephalon cell migration gliogenesis cell differentiation establishment of localization in cell anatomical structure development cell migration transport along microtubule system development head development brain development nucleus localization nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration intracellular transport nervous system development cerebral cortex radially oriented cell migration establishment of localization central nervous system development microtubule-based process cytoskeleton-dependent intracellular transport microtubule-based movement cerebral cortex radial glia-guided migration cellular developmental process transport forebrain development glial cell migration cerebral cortex development neurogenesis forebrain cell migration organelle localization nuclear migration cell motility cell motility involved in cerebral cortex radial glia guided migration cerebral cortex cell migration animal organ development modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration pallium development nuclear migration along microtubule microtubule-based transport telencephalon development cytoskeleton organization ossification meiotic chromosome segregation meiotic cell cycle organelle fission chromosome organization meiotic cell cycle process chromosome organization involved in meiotic cell cycle nuclear division meiosis I meiosis I cell cycle process homologous chromosome pairing at meiosis nuclear chromosome segregation meiotic nuclear division homologous chromosome segregation cell cycle chromosome segregation cell cycle process meiotic attachment of telomere to nuclear envelope telomere localization chromosome localization meiotic telomere clustering meiotic telomere tethering at nuclear periphery chromosome localization to nuclear envelope involved in homologous chromosome segregation telomere tethering at nuclear periphery chromosome attachment to the nuclear envelope establishment of chromosome localization	membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope nucleus cellular anatomical entity intracellular membrane-bounded organelle endomembrane system protein-containing complex membrane membrane protein complex nuclear protein-containing complex membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope nucleus cellular anatomical entity intracellular membrane-bounded organelle endomembrane system protein-containing complex membrane membrane protein complex nuclear protein-containing complex nuclear membrane protein complex microtubule organizing center attachment site nuclear membrane microtubule tethering complex meiotic nuclear membrane microtubule tethering complex nuclear membrane organelle membrane organelle inner membrane nuclear inner membrane cytoplasm intracellular non-membrane-bounded organelle chromosome chromosome, telomeric region chromosomal region non-membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000719	Protein kinase domain	Domain
A	IPR017441	Protein kinase, ATP binding site	Binding Site
A	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A	IPR008271	Serine/threonine-protein kinase, active site	Active Site
B	IPR020984	Cell cycle regulatory protein Speedy	Family
C	IPR045119	SUN domain-containing protein 1-5	Family
C	IPR012919	SUN domain	Domain
C	IPR040994	SUN coiled coil domain 2	Domain
C	IPR032680	SUN domain-containing protein 1, N-terminal	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P24941	melanoma glioblastoma large cell medulloblastoma malignant glioma medulloblastoma osteosarcoma adrenal cortex carcinoma primitive neuroectodermal tumor alopecia areata vitiligo atypical teratoid rhabdoid tumor Childhood Diffuse Large B-Cell Lymphoma diffuse large B-cell lymphoma malignant colon neoplasm pilocytic astrocytoma melanoma glioblastoma large cell medulloblastoma malignant glioma medulloblastoma osteosarcoma adrenal cortex carcinoma primitive neuroectodermal tumor alopecia areata vitiligo atypical teratoid rhabdoid tumor Childhood Diffuse Large B-Cell Lymphoma diffuse large B-cell lymphoma malignant colon neoplasm pilocytic astrocytoma psoriasis asthma breast disease cleft lip eye disease Hashimoto thyroiditis hypothyroidism malignant ependymoma malignant mesothelioma polycystic ovary syndrome allergic rhinitis rheumatoid arthritis attention deficit hyperactivity disorder, inattentive type cancer cutaneous melanoma gastroesophageal reflux disease hematologic disease
B	Pharos: Q5MJ70	breast carcinoma estrogen-receptor negative breast cancer
C	Pharos: O94901	atrial fibrillation gastric carcinoma malignant ependymoma oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma psoriasis tuberculosis cutaneous lupus erythematosus Hutchinson-Gilford progeria syndrome malignant mesothelioma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm rheumatoid arthritis gastric cancer invasive ductal breast carcinoma atrial fibrillation gastric carcinoma malignant ependymoma oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma psoriasis tuberculosis cutaneous lupus erythematosus Hutchinson-Gilford progeria syndrome malignant mesothelioma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm rheumatoid arthritis gastric cancer invasive ductal breast carcinoma medulloblastoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia spina bifida

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.