Annotations: 7DP3

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF17207	e7dp3A3	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF17207	ECOD (1.6)
A	F_UNCLASSIFIED	e7dp3A2	A: a+b complex topology	X: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	H: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	T: N-terminal subdomain in DNA replication initiator (cdc21/cdc54)	F: F_UNCLASSIFIED	ECOD (1.6)
A	F_UNCLASSIFIED	e7dp3A1	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF17207	e7dp3B3	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF17207	ECOD (1.6)
B	F_UNCLASSIFIED	e7dp3B1	A: a+b complex topology	X: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	H: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	T: N-terminal subdomain in DNA replication initiator (cdc21/cdc54)	F: F_UNCLASSIFIED	ECOD (1.6)
B	F_UNCLASSIFIED	e7dp3B2	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: F_UNCLASSIFIED	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF17207	MCM OB domain (MCM_OB)	MCM OB domain	This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	DNA helicase MCM8	protein-containing complex binding binding MutSalpha complex binding mismatch repair complex binding catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity MutSbeta complex binding chromatin binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding protein-containing complex binding binding MutSalpha complex binding mismatch repair complex binding catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity MutSbeta complex binding chromatin binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides MutLbeta complex binding protein binding enzyme binding DNA binding single-stranded DNA binding nucleic acid binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process regulation of protein stability biological regulation regulation of biological quality protein stabilization protein localization localization protein localization to chromatin cellular localization cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process regulation of protein stability biological regulation regulation of biological quality protein stabilization protein localization localization protein localization to chromatin cellular localization protein localization to chromosome protein localization to organelle cellular macromolecule localization macromolecule localization sexual reproduction reproductive process multicellular organismal reproductive process male gamete generation gamete generation cellular component organization DNA duplex unwinding organelle organization DNA geometric change chromosome organization DNA conformation change cellular component organization or biogenesis cell cycle female gamete generation mismatch repair DNA-templated DNA replication DNA-templated DNA replication maintenance of fidelity primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication DNA replication organic substance metabolic process metabolic process macromolecule metabolic process DNA repair DNA recombination recombinational interstrand cross-link repair recombinational repair interstrand cross-link repair double-strand break repair double-strand break repair via homologous recombination	protein-containing complex MCM complex membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen protein-containing complex MCM complex membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen intracellular non-membrane-bounded organelle chromosome non-membrane-bounded organelle MCM8-MCM9 complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR031327	Mini-chromosome maintenance protein	Family
A, B	IPR003593	AAA+ ATPase domain	Domain
A, B	IPR001208	MCM domain	Domain
A, B	IPR041562	MCM, AAA-lid domain	Domain
A, B	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A, B	IPR033762	MCM OB domain	Domain
A, B	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q9UJA3	premature ovarian failure 10 primary ovarian failure adrenal cortex carcinoma cystic fibrosis large cell medulloblastoma medulloblastoma non-small cell lung carcinoma premature menopause primitive neuroectodermal tumor atypical teratoid rhabdoid tumor glioblastoma lung adenocarcinoma MENOPAUSE, NATURAL, AGE AT, QUANTITATIVE TRAIT LOCUS 3 osteosarcoma uterine corpus leiomyoma premature ovarian failure 10 primary ovarian failure adrenal cortex carcinoma cystic fibrosis large cell medulloblastoma medulloblastoma non-small cell lung carcinoma premature menopause primitive neuroectodermal tumor atypical teratoid rhabdoid tumor glioblastoma lung adenocarcinoma MENOPAUSE, NATURAL, AGE AT, QUANTITATIVE TRAIT LOCUS 3 osteosarcoma uterine corpus leiomyoma breast cancer invasive ductal breast carcinoma malignant glioma nasopharyngeal carcinoma ovarian cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.