Annotations: 7DG2

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF07574	e7dg2A3	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF07574	ECOD (1.6)
A	PF08746	e7dg2A1	A: few secondary structure elements	X: RING/U-box-like	H: RING/U-box-like	T: RING/U-box	F: PF08746	ECOD (1.6)
B [auth C]	PF01454	e7dg2C1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF01454	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF07574	Nse1 non-SMC component of SMC5-6 complex (SMC_Nse1)	Nse1 non-SMC component of SMC5-6 complex	-	Family
A	PF08746	RING-like domain (zf-RING-like)	RING-like domain	This is a zinc finger domain that is related to the C3HC4 RING finger domain (Pfam:PF00097).	Domain
B [auth C]	PF01454	MAGE homology domain (MAGE)	MAGE homology domain	The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this fam ...	The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex [2-3]. Nse3 has been demonstrated to be important for meiosis[3].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Non-structural maintenance of chromosomes element 1 homolog	protein binding binding protein dimerization activity aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity cation binding ion binding protein binding binding protein dimerization activity aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity cation binding ion binding metal ion binding small molecule binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process metabolic process macromolecule metabolic process cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process metabolic process macromolecule metabolic process DNA repair DNA recombination	intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle chromosome chromosome, telomeric region cellular anatomical entity chromosomal region non-membrane-bounded organelle protein-containing complex catalytic complex SUMO ligase complex transferase complex Smc5-Smc6 complex intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle chromosome chromosome, telomeric region cellular anatomical entity chromosomal region non-membrane-bounded organelle protein-containing complex catalytic complex SUMO ligase complex transferase complex Smc5-Smc6 complex condensed chromosome membrane-bounded organelle nucleus intracellular membrane-bounded organelle
B [auth C]	MAGE domain-containing protein	-	-	-
C [auth D]	Non-structural maintenance of chromosomes element 4	-	cellular response to stimulus response to stimulus primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process cellular response to stress DNA damage response response to stress metabolic process cellular process macromolecule metabolic process cellular response to stimulus response to stimulus primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process cellular response to stress DNA damage response response to stress metabolic process cellular process macromolecule metabolic process DNA repair DNA recombination	intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle chromosome chromosome, telomeric region cellular anatomical entity chromosomal region non-membrane-bounded organelle protein-containing complex catalytic complex SUMO ligase complex transferase complex Smc5-Smc6 complex intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle chromosome chromosome, telomeric region cellular anatomical entity chromosomal region non-membrane-bounded organelle protein-containing complex catalytic complex SUMO ligase complex transferase complex Smc5-Smc6 complex condensed chromosome membrane-bounded organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR011513	Non-structural maintenance of chromosomes element 1	Family
A	IPR014857	Non-structural maintenance of chromosomes element 1, RING C4HC3-type	Domain
A	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
A	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
A	IPR046349	C1-like domain superfamily	Homologous Superfamily
B [auth C]	IPR041899	MAGE homology domain, winged helix WH2 motif	Homologous Superfamily
B [auth C]	IPR002190	MAGE homology domain	Domain
B [auth C]	IPR041898	MAGE homology domain, winged helix WH1 motif	Homologous Superfamily
B [auth C]	IPR037445	Melanoma-associated antigen	Family
C [auth D]	IPR027786	Nse4/EID family	Family
C [auth D]	IPR014854	Non-structural maintenance of chromosome element 4, C-terminal	Domain
C [auth D]	IPR029225	Nse4/EID protein, Nse3/MAGE-binding domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.