Annotations: 7CM3

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00520	Ion transport protein (Ion_trans)	Ion transport protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Sodium leak channel non-selective protein	passive transmembrane transporter activity narrow pore channel activity leak channel activity channel activity transporter activity transmembrane transporter activity monoatomic cation transmembrane transporter activity voltage-gated sodium channel activity monoatomic ion channel activity sodium channel activity sodium ion transmembrane transporter activity monoatomic cation channel activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity passive transmembrane transporter activity narrow pore channel activity leak channel activity channel activity transporter activity transmembrane transporter activity monoatomic cation transmembrane transporter activity voltage-gated sodium channel activity monoatomic ion channel activity sodium channel activity sodium ion transmembrane transporter activity monoatomic cation channel activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity metal ion transmembrane transporter activity	transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization calcium ion transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport calcium ion transmembrane transport transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization calcium ion transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport calcium ion transmembrane transport potassium ion transmembrane transport potassium ion transport regulation of resting membrane potential biological regulation regulation of biological quality regulation of membrane potential positive regulation of cell communication regulation of cellular process signaling modulation of chemical synaptic transmission positive regulation of synaptic transmission, GABAergic positive regulation of biological process cell communication synaptic signaling positive regulation of cellular process trans-synaptic signaling regulation of signaling regulation of biological process synaptic transmission, GABAergic positive regulation of synaptic transmission cell-cell signaling chemical synaptic transmission regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of cell communication positive regulation of signaling regulation of synaptic transmission, GABAergic positive regulation of synaptic transmission, cholinergic synaptic transmission, cholinergic regulation of synaptic transmission, cholinergic sodium ion transmembrane transport sodium ion transport	cell periphery plasma membrane membrane cellular anatomical entity protein-containing complex transmembrane transporter complex membrane protein complex transporter complex monoatomic ion channel complex
B	Transmembrane protein FAM155A	-	import into cell calcium ion transmembrane import into cytosol transport monoatomic ion transmembrane transport import across plasma membrane inorganic ion transmembrane transport establishment of localization inorganic cation import across plasma membrane calcium ion transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization calcium ion import across plasma membrane import into cell calcium ion transmembrane import into cytosol transport monoatomic ion transmembrane transport import across plasma membrane inorganic ion transmembrane transport establishment of localization inorganic cation import across plasma membrane calcium ion transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization calcium ion import across plasma membrane inorganic ion import across plasma membrane monoatomic ion transport cellular process calcium ion import calcium ion import into cytosol monoatomic cation transport calcium ion transmembrane transport	cell periphery plasma membrane membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR005821	Ion transport domain	Domain
A	IPR028823	Sodium leak channel NALCN	Family
A	IPR027359	Voltage-dependent channel domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q8IZF0	congenital contractures of the limbs and face, hypotonia, and developmental delay hypotonia, infantile, with psychomotor retardation and characteristic facies 1 digitotalar dysmorphism freeman-Sheldon syndrome pancreatic intraductal papillary-mucinous carcinoma Pick disease schizophrenia arthrogryposis DOID:0081048 large cell medulloblastoma malignant glioma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm primitive neuroectodermal tumor Sheldon-hall syndrome congenital contractures of the limbs and face, hypotonia, and developmental delay hypotonia, infantile, with psychomotor retardation and characteristic facies 1 digitotalar dysmorphism freeman-Sheldon syndrome pancreatic intraductal papillary-mucinous carcinoma Pick disease schizophrenia arthrogryposis DOID:0081048 large cell medulloblastoma malignant glioma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm primitive neuroectodermal tumor Sheldon-hall syndrome atypical teratoid rhabdoid tumor intellectual disability lung carcinoma medulloblastoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia psoriasis subependymal giant cell astrocytoma breast cancer distal arthrogryposis type 2B1 glioblastoma interstitial cystitis malignant ependymoma neurodegenerative disease
B	Pharos: B1AL88	astrocytic tumor cystic fibrosis facioscapulohumeral muscular dystrophy large cell medulloblastoma malignant mesothelioma ovarian cancer spina bifida atypical teratoid rhabdoid tumor Diverticular Diseases glioblastoma malignant ependymoma medulloblastoma pilocytic astrocytoma breast fibroadenoma diverticulitis astrocytic tumor cystic fibrosis facioscapulohumeral muscular dystrophy large cell medulloblastoma malignant mesothelioma ovarian cancer spina bifida atypical teratoid rhabdoid tumor Diverticular Diseases glioblastoma malignant ependymoma medulloblastoma pilocytic astrocytoma breast fibroadenoma diverticulitis interstitial cystitis malignant glioma osteosarcoma primitive neuroectodermal tumor

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B	OPM	Transmembrane	Alpha-helical polytopic	Ion channel (VIC) superfamily	Sodium leak channel NALCN

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Channels: Potassium, Sodium, & Proton Ion-Selective	Na⁺ leak channel non-selective (NALCN) in complex with FAM155A

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.