7CE1

Complex STRUCTURE OF TRANSCRIPTION FACTOR SghR with its COGNATE DNA

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00356	e7ce1A2	A: alpha arrays	X: HTH	H: HTH	T: tetra-helical, lambda repressor-like	F: PF00356	ECOD (1.6)
A	F_UNCLASSIFIED	e7ce1A3	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Periplasmic binding protein-like I	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF13377	e7ce1A1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Periplasmic binding protein-like I	F: PF13377	ECOD (1.6)
B	PF00356	e7ce1B2	A: alpha arrays	X: HTH	H: HTH	T: tetra-helical, lambda repressor-like	F: PF00356	ECOD (1.6)
B	F_UNCLASSIFIED	e7ce1B3	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Periplasmic binding protein-like I	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF13377	e7ce1B1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Periplasmic binding protein-like I	F: PF13377	ECOD (1.6)
E [auth C]	PF00356	e7ce1C2	A: alpha arrays	X: HTH	H: HTH	T: tetra-helical, lambda repressor-like	F: PF00356	ECOD (1.6)
E [auth C]	F_UNCLASSIFIED	e7ce1C3	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Periplasmic binding protein-like I	F: F_UNCLASSIFIED	ECOD (1.6)
E [auth C]	PF13377	e7ce1C1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Periplasmic binding protein-like I	F: PF13377	ECOD (1.6)
F [auth D]	PF00356	e7ce1D3	A: alpha arrays	X: HTH	H: HTH	T: tetra-helical, lambda repressor-like	F: PF00356	ECOD (1.6)
F [auth D]	F_UNCLASSIFIED	e7ce1D2	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Periplasmic binding protein-like I	F: F_UNCLASSIFIED	ECOD (1.6)
F [auth D]	PF13377	e7ce1D1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Periplasmic binding protein-like I	F: PF13377	ECOD (1.6)
I [auth G]	PF00356	e7ce1G2	A: alpha arrays	X: HTH	H: HTH	T: tetra-helical, lambda repressor-like	F: PF00356	ECOD (1.6)
I [auth G]	F_UNCLASSIFIED	e7ce1G1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Periplasmic binding protein-like I	F: F_UNCLASSIFIED	ECOD (1.6)
I [auth G]	PF13377	e7ce1G3	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Periplasmic binding protein-like I	F: PF13377	ECOD (1.6)
J [auth H]	PF00356	e7ce1H1	A: alpha arrays	X: HTH	H: HTH	T: tetra-helical, lambda repressor-like	F: PF00356	ECOD (1.6)
J [auth H]	F_UNCLASSIFIED	e7ce1H2	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Periplasmic binding protein-like I	F: F_UNCLASSIFIED	ECOD (1.6)
J [auth H]	PF13377	e7ce1H3	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Periplasmic binding protein-like I	F: PF13377	ECOD (1.6)
M [auth K]	PF00356	e7ce1K1	A: alpha arrays	X: HTH	H: HTH	T: tetra-helical, lambda repressor-like	F: PF00356	ECOD (1.6)
M [auth K]	F_UNCLASSIFIED	e7ce1K2	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Periplasmic binding protein-like I	F: F_UNCLASSIFIED	ECOD (1.6)
M [auth K]	PF13377	e7ce1K3	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Periplasmic binding protein-like I	F: PF13377	ECOD (1.6)
N [auth L]	PF00356	e7ce1L1	A: alpha arrays	X: HTH	H: HTH	T: tetra-helical, lambda repressor-like	F: PF00356	ECOD (1.6)
N [auth L]	F_UNCLASSIFIED	e7ce1L2	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Periplasmic binding protein-like I	F: F_UNCLASSIFIED	ECOD (1.6)
N [auth L]	PF13377	e7ce1L3	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Periplasmic binding protein-like I	F: PF13377	ECOD (1.6)
Q [auth O]	PF00356	e7ce1O2	A: alpha arrays	X: HTH	H: HTH	T: tetra-helical, lambda repressor-like	F: PF00356	ECOD (1.6)
Q [auth O]	F_UNCLASSIFIED	e7ce1O1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Periplasmic binding protein-like I	F: F_UNCLASSIFIED	ECOD (1.6)
Q [auth O]	PF13377	e7ce1O3	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Periplasmic binding protein-like I	F: PF13377	ECOD (1.6)
R [auth P]	PF00356	e7ce1P1	A: alpha arrays	X: HTH	H: HTH	T: tetra-helical, lambda repressor-like	F: PF00356	ECOD (1.6)
R [auth P]	F_UNCLASSIFIED	e7ce1P3	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Periplasmic binding protein-like I	F: F_UNCLASSIFIED	ECOD (1.6)
R [auth P]	PF13377	e7ce1P2	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Periplasmic binding protein-like I	F: PF13377	ECOD (1.6)
U [auth S]	PF00356	e7ce1S3	A: alpha arrays	X: HTH	H: HTH	T: tetra-helical, lambda repressor-like	F: PF00356	ECOD (1.6)
U [auth S]	F_UNCLASSIFIED	e7ce1S2	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Periplasmic binding protein-like I	F: F_UNCLASSIFIED	ECOD (1.6)
V [auth T]	PF00356	e7ce1T3	A: alpha arrays	X: HTH	H: HTH	T: tetra-helical, lambda repressor-like	F: PF00356	ECOD (1.6)
V [auth T]	F_UNCLASSIFIED	e7ce1T1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Periplasmic binding protein-like I	F: F_UNCLASSIFIED	ECOD (1.6)
V [auth T]	PF13377	e7ce1T2	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Periplasmic binding protein-like I	F: PF13377	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, E [auth C], F [auth D], I [auth G], A, B, E [auth C], F [auth D], I [auth G], J [auth H], M [auth K], N [auth L], Q [auth O], R [auth P], U [auth S], V [auth T]	PF13377	Periplasmic binding protein-like domain (Peripla_BP_3)	Periplasmic binding protein-like domain	This domain is found in a variety of transcriptional regulatory proteins. It is related to bacterial periplasmic binding proteins, although this domain is unlikely to be found in the periplasm. This domain acts as a sensor binding small molecule liga ...	This domain is found in a variety of transcriptional regulatory proteins. It is related to bacterial periplasmic binding proteins, although this domain is unlikely to be found in the periplasm. This domain acts as a sensor binding small molecule ligands that the DNA-binding domain responds to. This domain recognises Sugars, sugar phosphates, sugar acids and purines (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).	Domain
A, B, E [auth C], F [auth D], I [auth G], A, B, E [auth C], F [auth D], I [auth G], J [auth H], M [auth K], N [auth L], Q [auth O], R [auth P], U [auth S], V [auth T]	PF00356	Bacterial regulatory proteins, lacI family (LacI)	Bacterial regulatory proteins, lacI family	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, E [auth C], F [auth D], I [auth G], A, B, E [auth C], F [auth D], I [auth G], J [auth H], M [auth K], N [auth L], Q [auth O], R [auth P], U [auth S], V [auth T]	LacI-type transcription factor	DNA binding binding organic cyclic compound binding nucleic acid binding	regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of biological process cellular metabolic process biological regulation primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process cellular process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process	-
C [auth a], D [auth b], G [auth c], H [auth d], K [auth g], C [auth a], D [auth b], G [auth c], H [auth d], K [auth g], L [auth h], O [auth k], P [auth l], S [auth o], T [auth p], W [auth s], X [auth t]	promoter DNA	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, E [auth C], F [auth D], I [auth G], A, B, E [auth C], F [auth D], I [auth G], J [auth H], M [auth K], N [auth L], Q [auth O], R [auth P], U [auth S], V [auth T]	IPR046335	Transcriptional regulator LacI/GalR-like, sensor domain	Domain
A, B, E [auth C], F [auth D], I [auth G], A, B, E [auth C], F [auth D], I [auth G], J [auth H], M [auth K], N [auth L], Q [auth O], R [auth P], U [auth S], V [auth T]	IPR000843	LacI-type HTH domain	Domain
A, B, E [auth C], F [auth D], I [auth G], A, B, E [auth C], F [auth D], I [auth G], J [auth H], M [auth K], N [auth L], Q [auth O], R [auth P], U [auth S], V [auth T]	IPR028082	Periplasmic binding protein-like I	Homologous Superfamily
A, B, E [auth C], F [auth D], I [auth G], A, B, E [auth C], F [auth D], I [auth G], J [auth H], M [auth K], N [auth L], Q [auth O], R [auth P], U [auth S], V [auth T]	IPR010982	Lambda repressor-like, DNA-binding domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.

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7CE1

Complex STRUCTURE OF TRANSCRIPTION FACTOR SghR with its COGNATE DNA

External Resource: Annotation

Domain Annotation: ECOD Classification ECOD Database Homepage

Protein Family Annotation Pfam Database Homepage

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

InterPro: Protein Family Classification InterPro Database Homepage