7C4R

Crystal structure of hydrogen peroxide treated zebrafish TRF2 complexed with DNA

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Homeodomain-like	8103406	3000001	SCOP2B (2022-06-29)
D [auth B]	SCOP2B Superfamily	Homeodomain-like	8103406	3000001	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00249	e7c4rA1	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: PF00249	ECOD (1.6)
D [auth B]	PF00249	e7c4rB1	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: PF00249	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, D [auth B]	PF00249	Myb-like DNA-binding domain (Myb_DNA-binding)	Myb-like DNA-binding domain	This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, D [auth B]	Terfa protein	sequence-specific DNA binding DNA binding double-stranded telomeric DNA binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding telomeric DNA binding G-rich strand telomeric DNA binding sequence-specific single stranded DNA binding single-stranded telomeric DNA binding single-stranded DNA binding identical protein binding protein binding sequence-specific DNA binding DNA binding double-stranded telomeric DNA binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding telomeric DNA binding G-rich strand telomeric DNA binding sequence-specific single stranded DNA binding single-stranded telomeric DNA binding single-stranded DNA binding identical protein binding protein binding protein homodimerization activity protein dimerization activity telomerase activity RNA-directed DNA polymerase activity catalytic activity, acting on DNA DNA polymerase activity catalytic activity, acting on a nucleic acid transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups	cellular process cell cycle telomere organization chromosome organization primary metabolic process DNA metabolic process telomeric loop formation nucleic acid metabolic process telomere maintenance cellular component organization nucleobase-containing compound metabolic process organic cyclic compound metabolic process organelle organization organic substance metabolic process cellular process cell cycle telomere organization chromosome organization primary metabolic process DNA metabolic process telomeric loop formation nucleic acid metabolic process telomere maintenance cellular component organization nucleobase-containing compound metabolic process organic cyclic compound metabolic process organelle organization organic substance metabolic process metabolic process cellular component organization or biogenesis macromolecule metabolic process regulation of telomere maintenance regulation of cellular component organization regulation of cellular process cellular biosynthetic process regulation of DNA biosynthetic process regulation of primary metabolic process RNA-templated DNA biosynthetic process telomere maintenance via telomere lengthening nucleic acid biosynthetic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of biosynthetic process regulation of biological process telomere maintenance via telomerase cellular metabolic process biological regulation regulation of cellular metabolic process regulation of chromosome organization regulation of macromolecule metabolic process regulation of telomere maintenance via telomere lengthening nucleobase-containing compound biosynthetic process macromolecule biosynthetic process regulation of organelle organization regulation of telomere maintenance via telomerase regulation of cellular biosynthetic process biosynthetic process organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of metabolic process DNA biosynthetic process regulation of DNA metabolic process telomeric loop disassembly negative regulation of telomere maintenance regulation of telomeric loop disassembly negative regulation of biological process negative regulation of chromosome organization negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process negative regulation of cellular component organization telomeric D-loop disassembly negative regulation of metabolic process regulation of telomeric D-loop disassembly negative regulation of telomeric D-loop disassembly negative regulation of organelle organization negative regulation of DNA metabolic process negative regulation of telomeric loop disassembly protein localization localization cellular localization protein localization to chromosome protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to chromosome, telomeric region cellular response to stimulus telomere maintenance in response to DNA damage response to stimulus cellular response to stress response to stress protection from non-homologous end joining at telomere telomere capping DNA damage response regulation of DNA recombination regulation of telomere maintenance via recombination negative regulation of telomere maintenance via recombination negative regulation of DNA recombination at telomere negative regulation of mitotic recombination DNA recombination negative regulation of DNA recombination regulation of DNA recombination at telomere regulation of mitotic recombination telomere maintenance via recombination mitotic recombination	membrane-bounded organelle protein-containing complex intracellular anatomical structure protein-DNA complex nucleus nuclear protein-containing complex chromosome cellular anatomical entity intracellular membrane-bounded organelle chromosomal region intracellular organelle organelle telomere cap complex intracellular non-membrane-bounded organelle membrane-bounded organelle protein-containing complex intracellular anatomical structure protein-DNA complex nucleus nuclear protein-containing complex chromosome cellular anatomical entity intracellular membrane-bounded organelle chromosomal region intracellular organelle organelle telomere cap complex intracellular non-membrane-bounded organelle chromosome, telomeric repeat region chromosome, telomeric region shelterin complex non-membrane-bounded organelle nuclear telomere cap complex
B [auth C]	DNA (5'-D(DTPDPTPDPAPDPGPDPGPDPGPDPTPDPTPDPAPDPGPDPGPDPG)-3')	-	-	-
C [auth D], F	DNA (5'-D(DCPDPCPDPCPDPTPDPAPDPAPDPCPDPCPDPCPDPTPDPAPDPA)-3')	-	-	-
E	DNA (5'-D(DTPDPTPDPAPDPGPDPGPDPGPDPTPDPTPDPAPDPG)-3')	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, D [auth B]	IPR009057	Homedomain-like superfamily	Homologous Superfamily
A, D [auth B]	IPR036507	Telomere repeat-binding factor, dimerisation domain superfamily	Homologous Superfamily
A, D [auth B]	IPR030657	Telomeric repeat-binding factor 2	Family
A, D [auth B]	IPR017930	Myb domain	Domain
A, D [auth B]	IPR001005	SANT/Myb domain	Domain
A, D [auth B]	IPR013867	Telomere repeat-binding factor, dimerisation domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.