Annotations: 7BZX

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth B]	PF02780	e7bzxB3	A: a/b three-layered sandwiches	X: TK C-terminal domain-like (From Topology)	H: TK C-terminal domain-like (From Topology)	T: TK C-terminal domain-like	F: PF02780	ECOD (1.6)
A [auth B]	PF02779	e7bzxB2	A: a/b three-layered sandwiches	X: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)	H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)	T: Thiamin diphosphate-binding fold (THDP-binding)	F: PF02779	ECOD (1.6)
A [auth B]	PF13292	e7bzxB1	A: a/b three-layered sandwiches	X: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)	H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)	T: Thiamin diphosphate-binding fold (THDP-binding)	F: PF13292	ECOD (1.6)
B [auth A]	PF02780	e7bzxA3	A: a/b three-layered sandwiches	X: TK C-terminal domain-like (From Topology)	H: TK C-terminal domain-like (From Topology)	T: TK C-terminal domain-like	F: PF02780	ECOD (1.6)
B [auth A]	PF02779	e7bzxA2	A: a/b three-layered sandwiches	X: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)	H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)	T: Thiamin diphosphate-binding fold (THDP-binding)	F: PF02779	ECOD (1.6)
B [auth A]	PF13292	e7bzxA1	A: a/b three-layered sandwiches	X: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)	H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)	T: Thiamin diphosphate-binding fold (THDP-binding)	F: PF13292	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B], B [auth A]	PF02779	Transketolase, pyrimidine binding domain (Transket_pyr)	Transketolase, pyrimidine binding domain	This family includes transketolase enzymes, pyruvate dehydrogenases, and branched chain alpha-keto acid decarboxylases.	Domain
A [auth B], B [auth A]	PF13292	1-deoxy-D-xylulose-5-phosphate synthase (DXP_synthase_N)	1-deoxy-D-xylulose-5-phosphate synthase	-	Family
A [auth B], B [auth A]	PF02780	Transketolase, C-terminal domain (Transketolase_C)	Transketolase, C-terminal domain	The C-terminal domain of transketolase has been proposed as a regulatory molecule binding site [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B], B [auth A]	1-deoxy-D-xylulose-5-phosphate synthase, chloroplastic	transketolase or transaldolase activity 1-deoxy-D-xylulose-5-phosphate synthase activity transferase activity catalytic activity cation binding ion binding binding metal ion binding small molecule binding identical protein binding protein binding	cellular biosynthetic process isopentenyl diphosphate biosynthetic process lipid biosynthetic process carbohydrate derivative metabolic process glyceraldehyde-3-phosphate metabolic process phospholipid metabolic process organic substance metabolic process cellular aldehyde metabolic process organic substance biosynthetic process phosphate-containing compound metabolic process phosphorus metabolic process isoprenoid biosynthetic process isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway cellular metabolic process cellular biosynthetic process isopentenyl diphosphate biosynthetic process lipid biosynthetic process carbohydrate derivative metabolic process glyceraldehyde-3-phosphate metabolic process phospholipid metabolic process organic substance metabolic process cellular aldehyde metabolic process organic substance biosynthetic process phosphate-containing compound metabolic process phosphorus metabolic process isoprenoid biosynthetic process isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway cellular metabolic process primary metabolic process phospholipid biosynthetic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process cellular lipid metabolic process metabolic process cellular process lipid metabolic process isoprenoid metabolic process isopentenyl diphosphate metabolic process pigment metabolic process organonitrogen compound metabolic process porphyrin-containing compound biosynthetic process tetrapyrrole metabolic process chlorophyll metabolic process organonitrogen compound biosynthetic process pigment biosynthetic process organic cyclic compound metabolic process tetrapyrrole biosynthetic process organic cyclic compound biosynthetic process porphyrin-containing compound metabolic process chlorophyll biosynthetic process terpenoid biosynthetic process terpenoid metabolic process carbohydrate derivative biosynthetic process 1-deoxy-D-xylulose 5-phosphate biosynthetic process 1-deoxy-D-xylulose 5-phosphate metabolic process organic hydroxy compound metabolic process thiamine-containing compound metabolic process vitamin biosynthetic process alcohol metabolic process thiamine metabolic process thiamine biosynthetic process small molecule metabolic process sulfur compound metabolic process pyrimidine-containing compound biosynthetic process primary alcohol biosynthetic process water-soluble vitamin metabolic process pyrimidine-containing compound metabolic process water-soluble vitamin biosynthetic process small molecule biosynthetic process vitamin metabolic process sulfur compound biosynthetic process organic hydroxy compound biosynthetic process alcohol biosynthetic process thiamine-containing compound biosynthetic process primary alcohol metabolic process	membrane-bounded organelle intracellular anatomical structure plastid cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle plastid stroma organelle chloroplast stroma cytoplasm chloroplast

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B], B [auth A]	IPR005477	Deoxyxylulose-5-phosphate synthase	Family
A [auth B], B [auth A]	IPR029061	Thiamin diphosphate-binding fold	Homologous Superfamily
A [auth B], B [auth A]	IPR009014	Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II	Homologous Superfamily
A [auth B], B [auth A]	IPR049557	Transketolase conserved site	Conserved Site
A [auth B], B [auth A]	IPR005475	Transketolase-like, pyrimidine-binding domain	Domain
A [auth B], B [auth A]	IPR033248	Transketolase, C-terminal domain	Domain
A [auth B], B [auth A]	IPR020826	Transketolase binding site	Binding Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.